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. 1987 Mar;6(3):591–598. doi: 10.1002/j.1460-2075.1987.tb04795.x

Single amino acid changes that render human IFN-alpha 2 biologically active on mouse cells.

H Weber, D Valenzuela, G Lujber, M Gubler, C Weissmann
PMCID: PMC553438  PMID: 3034596

Abstract

Human IFN-alpha 1 and IFN-alpha 2 differ in 28 of 166 amino acids and show very different specific antiviral activities on human and murine cells. We have identified, by hybrid scanning and site-directed mutagenesis, three residues in IFN-alpha 2, in positions 121, 125 and 132 which, when replaced individually or jointly by their IFN-alpha 1 counterparts, modify its activity on mouse cells by up to 400-fold. We argue that these residues are involved in direct contacts with the mouse interferon receptor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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