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. 1987 Mar;6(3):809–814. doi: 10.1002/j.1460-2075.1987.tb04823.x

Autoregulation of bacteriophage P2 repressor.

S Saha, B Lundqvist, E Haggård-Ljungquist
PMCID: PMC553466  PMID: 3034610

Abstract

The immunity repressor of bacteriophage P2 regulates the two convergent promoters, Pe and Pc, located in the early control region. Pe is the early promoter which is negatively regulated by the repressor. It was found, by DNase I protection studies, that the P2 repressor enhances the binding of RNA polymerase to Pc. Furthermore, under in vivo conditions the transcription initiated at Pc, measured as chloramphenicol acetyl transferase gene expression, is low in the absence of repressor but is stimulated by low repressor levels. With increasing repressor concentrations transcription from the Pc promoter decreases. Thus, the P2 repressor both negatively and positively regulates its own promoter.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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