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. 1987 Nov;6(11):3291–3297. doi: 10.1002/j.1460-2075.1987.tb02648.x

Construction of a detailed molecular map of the mouse X chromosome by microcloning and interspecific crosses.

N Brockdorff 1, E M Fisher 1, J S Cavanna 1, M F Lyon 1, S D Brown 1
PMCID: PMC553782  PMID: 2448136

Abstract

A large number of microclones obtained by microdissection of the mouse X chromosome have been mapped using an interspecific Mus domesticus/Mus spretus cross. Clones displaying close linkage to a number of loci of known phenotype but unknown gene product, such as mdx (X-linked muscular dystrophy), have been obtained. Over a central 30 cM span of the mouse X chromosome, 17 clones have been mapped and ordered at a sufficient density to contemplate the complete physical mapping of this region that will aid in the isolation of a number of unidentified genes. Some of the mapped microclones detect moderately repetitive sequences that were clustered in several discrete regions of the mouse X chromosome.

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Selected References

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