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. 1983;2(12):2281–2283. doi: 10.1002/j.1460-2075.1983.tb01735.x

Localisation of the human N-ras oncogene to chromosome 1cen - p21 by in situ hybridisation.

M Davis, S Malcolm, A Hall, C J Marshall
PMCID: PMC555446  PMID: 6667677

Abstract

The N-ras gene is a transforming gene isolated from a variety of human tumour cell lines and is a member of a family of related ras genes. Somatic cell hybrids have previously shown that the N-ras gene is located on chromosome 1. We have confirmed this localisation by in situ hybridisation to metaphase preparations of lymphocytes and localised the gene to the region 1cen - p21. A survey has found 47 reported cases of malignancy involving deletions in the short arm of chromosome 1. Fifteen of the 47 involved a deletion in this region.

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Selected References

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