Skip to main content
PMC home page
The EMBO Journal logoLink to The EMBO Journal
. 1984 May;3(5):999–1002. doi: 10.1002/j.1460-2075.1984.tb01919.x

The zeste-white interaction: induction and genetic analysis of a novel class of zeste alleles

Eliezer Lifschytz 1,*, Melvin M Green 1
PMCID: PMC557463  PMID: 16453528

Abstract

The recovery and analysis of a novel class of zeste mutations is described. zop6 and zop11 do not require two w+ genes for their expression unless the z+ gene is present. Analysis of genetic interactions among zeste alleles proved that zop mutations are strong antagonists of the z+ gene product. zop6 is readily reverted by X-rays or by ethylmethane sulphonate to a range of intermediate zeste alleles and thus it is considered to be an insertional mutation. We suggest that z1 and op mutations arose as a result of insertions in a presumptive control region, and two alternative models for the structure of the zeste locus are evaluated.

Keywords: Drosophila, zeste alleles, zeste-white interaction

Full text

PDF
1001

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ferris S. D., Whitt G. S. Loss of duplicate gene expression after polyploidisation. Nature. 1977 Jan 20;265(5591):258–260. doi: 10.1038/265258a0. [DOI] [PubMed] [Google Scholar]
  2. Gelbart W. M., Wu C. T. Interactions of zeste mutations with loci exhibiting transvection effects in Drosophila melanogaster. Genetics. 1982 Oct;102(2):179–189. doi: 10.1093/genetics/102.2.179. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Green M. M., Lefevre G., Jr Genetic instability in Drosophila melanogaster: tandem duplications as monitors of intrastrand exchange. Chromosoma. 1979 Oct 1;74(3):329–335. doi: 10.1007/BF01190747. [DOI] [PubMed] [Google Scholar]
  4. JUDD B. H. Formation of duplication-deficiency products by asymmetrical exchange within a complex locus of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1961 Apr 15;47:545–550. doi: 10.1073/pnas.47.4.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jack J. W., Judd B. H. Allelic pairing and gene regulation: A model for the zeste-white interaction in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1368–1372. doi: 10.1073/pnas.76.3.1368. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kaufman T. C., Shannon M. P., Shen M. W., Judd B. H. A revision of the cytology and ontogeny of several deficiencies in the 3A1-3C6 region of the X chromosome of Drosophila melanogaster. Genetics. 1975 Feb;79(2):265–282. doi: 10.1093/genetics/79.2.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lifschytz E., Falk R. A genetic analysis of the killer-prune (K-pn) locus of Drosophila melanogaster. Genetics. 1969 Jun;62(2):353–358. doi: 10.1093/genetics/62.2.353. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lifschytz E., Green M. M. Genetic identification of dominant overproducing mutations: the Beadex gene. Mol Gen Genet. 1979 Mar 20;171(2):153–159. doi: 10.1007/BF00270001. [DOI] [PubMed] [Google Scholar]
  9. Ono S. Ancient linkage groups and frozen accidents. Nature. 1973 Aug 3;244(5414):259–262. doi: 10.1038/244259a0. [DOI] [PubMed] [Google Scholar]

Articles from The EMBO Journal are provided here courtesy of Nature Publishing Group

RESOURCES