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. 1990 May;81(5):440–444. doi: 10.1111/j.1349-7006.1990.tb02588.x

Ick Suppresses Gene Expression from Various Promoters Including Human T‐Cell Leukemia Virus Type I Promoter

Masataka Ohta 1, Toshirou Morita 1, Kunitada Shimotohno 1
PMCID: PMC5918062  PMID: 2116390

Abstract

The T‐lymphocyte‐specific tyrosine kinase gene, Ick, is expressed in T‐lymphocyte cell lines, except for several human T‐cell leukemia virus type I(HTLV‐I)‐transformed T‐lymphocyte cell lines, which produce HTLV‐I. By introducing an Ick‐expression vector, we found that Ick product suppresses gene expression from HTLV‐I promoter in a transient assay. Moreover, various other promoters of cellular genes or viruses were found to have their transcriptional activity repressed by Ic.

Keywords: Ick, HTLV‐I, Promoter

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