Abstract
A historical cohort study was conducted in Misasa town, Tottori prefecture, Japan, where radon spas have been operating for a long time. Misasa town was divided into an elevated radon level area and a control area, with mean indoor radon levels of about 60 and 20 Bq/m3, respectively. In total, 3,083 subjects in the elevated radon level area and 1,248 in the control area, all aged 40 or older on January 1, 1976, were followed up until December 31, 1993, for a mean period of 14 years. The mortality rates from all causes exhibited no difference between the elevated radon level area and the control area for both sexes. No difference was observed in the incidence of all‐site cancers (age, period‐adjusted rate ratios by Poisson regression, RR=1.06, 95% confidence interval (CI) 0.79–1.42 for males, RR=0.90, 95% CI 0.65–1.24 for females), while stomach cancer incidence seemed to decrease for both sexes (RR=0.70, 95% CI 0.44–1.11 for male, RR=0.58, 95% CI 0.34–1.00 for female) and lung cancer incidence for males only seemed to increase (RR=1.65, 95% CI 0.83–3.30 for male, RR=1.07, 95% CI 0.28–4.14 for female) in the elevated radon level area. Caution is needed in the interpretation of these findings, however, since the individual exposure level was not measured and major confounding factors, such as smoking and diet, could not be controlled in this study.
Keywords: key words, Cancer incidence, Mortality, Radon spa, Indoor radon exposure, Risk
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REFERENCES
- 1. ) Lubin , J. H. , Boice , J. D. , Edling , C. , Hornung , R. W. , Howe , G. R. , Kunz , E. , Kusiak , R. A. , Morrison , H. I. , Radford , E. P. , Samet , J. M. , Tirmarche , M. , Woodward , A. , Yao , S. X. and Pierce , D. A.Lung cancer in radon‐exposed miners and estimation of risk from indoor exposure . J. Natl. Cancer Inst. , 87 , 817 – 827 ( 1995. ). [DOI] [PubMed] [Google Scholar]
- 2. ) Boice , J. D.Radon, your home or mine? Radiat. Res. , 147 , 135 – 137 ( 1997. ). [PubMed] [Google Scholar]
- 3. ) Cross , F. T.Invited commentary: residential radon risks from the perspective of experimental animal studies . Am. J. Epidemiol. , 140 , 333 – 339 ( 1994. ). [DOI] [PubMed] [Google Scholar]
- 4. ) National Research Council. “Report of the Committee on the Biological Effects of Ionizing Radiation (BEIR IV): Health Effects of Radon and Other Internally Deposited Alpha Emitters” ( 1988. ). National Academy Press; , Washington , DC . [Google Scholar]
- 5. ) Samet , J. M.Indoor radon exposure and lung cancer: risky or not? All over again . J. Natl. Cancer Inst. , 89 , 4 – 5 ( 1997. ). [DOI] [PubMed] [Google Scholar]
- 6. ) Morinaga , H. , Mifune , M. and Furuno , K.Radioactivity of water and air in Misasa spa, Japan . Radiat. Prot. Dosim. , 7 , 295 – 297 ( 1983. ). [Google Scholar]
- 7. ) Mifune , M. , Sobue , T. , Arimoto , H. , Komoto , Y. , Kondo , S. and Tanooka , H.Cancer mortality survey in a spa area (Misasa, Japan) with a high radon background . Jpn. J. Cancer Res. , 83 , 1 – 5 ( 1992. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8. ) Koga , T. , Inagaki , M. , Morishima , H. , Tanaka , Y. , Nakanishi , A. , Sasaki , N. and Mifune , M.Measurement of radon in Misasa district, Tottori pref., using the PICO‐RAD detector and a liquid scintillation spectrometer (3) . Annu. Rep. Kinki Univ. Atomic Energy Res. Inst. , 33 , 11 – 23 ( 1996. ) ( in Japanese ). [Google Scholar]
- 9. ) Breslow , N. E. and Day , N. E.The design and analysis of cohort studies . In“Statistical Methods in Cancer Research. Vol 2,” IARC Scientific Publication No. 82 ( 1987. ). International Agency for Research on Cancer; , Lyon , France . [PubMed] [Google Scholar]
- 10. ) SAS Institute, Inc. “SAS/STAT Software: Changes and Enhancements through Release 6.11” ( 1996. ). SAS Institute, Inc. , Cary , NC . [Google Scholar]
- 11. ) Monchaux , G. , Morlier , J. P. , Fritsch , P. , Rochefort , P. , Douriez , E. , Morin , M. and Maximilien , R.Co‐carcinogenic effects of various agents in rats following exposure to radon and radon daughters . Environ. Intern. , 22 ( Suppl. 1 ), s917 – s925 ( 1996. ). [Google Scholar]
- 12. ) Darby , S. C. , Whitley , E. , Howe , G. R. , Hutchings , S. J. , Kusiak , R. A. , Lubin , J. H. , Morrison , H. I. , Tirmarche , M. , Tomasek , L. , Radford , E. P. , Roscoe , R. J. , Samet , J. M. and Yao , S. X.Radon and cancers other than lung cancer in underground miners: a collaborative analysis of 11 studies . J. Natl. Cancer Inst. , 87 , 378 – 384 ( 1995. ). [DOI] [PubMed] [Google Scholar]
- 13. ) Nomura , A.Stomach cancer . In“Cancer Epidemiology and Prevention,” ed. Schottenfeld D. and Fraumeni J. F. , pp. 707 – 724 ( 1996. ). Oxford University Press; , New York . [Google Scholar]
- 14. ) Luckey , T. D.“Radiation Hormesis” ( 1991. ). CRC Press; , Boca Raton , FL . [Google Scholar]
- 15. ) Suzuki , Y. , Honjo , S. , Kawamura , H. , Koishi , F. , Suzuki , T. and Hirohata , T.Cancer mortality in low radon spa area . Jpn. J. Cancer Res. , 85 , 1063 – 1066 ( 1994. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 16. ) Fujimoto , K. , Kobayashi , S. , Uchiyama , M. , Doi , M. and Nakamura , Y.Nationwide indoor radon survey in Japan . J. Health Phys. , 32 , 41 – 51 ( 1997. ) ( in Japanese ). [Google Scholar]
- 17. ) Hei , T. K. , Wu , L. , Liu , S. , Vannais , D. and Waldren , C.Mutagenic effects of a single and an exact number of α particles in mammalian cells . Proc. Natl. Acad. Sci. USA , 94 , 3765 – 3770 ( 1997. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 18. ) Lubin , J. H. and Boice , J. D.Lung cancer risk from residential radon: meta‐analysis of eight epidemiologic studies . J. Natl. Cancer Inst. , 89 , 49 – 57 ( 1997. ). [DOI] [PubMed] [Google Scholar]
- 19. ) Haynes , R. M.The distribution of domestic radon concentrations and lung cancer mortality in England and Wales . Radiat. Prot. Dosim. , 25 , 93 – 96 ( 1988. ). [Google Scholar]
- 20. ) Cohen , B. L.Test of the linear‐no threshold theory of radiation carcinogenesis for inhaled radon decay products . Health Phys. , 68 , 157 – 174 ( 1995. ). [DOI] [PubMed] [Google Scholar]
- 21. ) Greenland , S. and Robins , J.Invited commentary: ecologic studies—biases, misconceptions, and counterexamples . Am. J. Epidemiol. , 139 , 747 – 760 ( 1994. ). [DOI] [PubMed] [Google Scholar]