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BMJ Open Access logoLink to BMJ Open Access
. 2018 Feb 24;67(6):1000–1023. doi: 10.1136/gutjnl-2017-315414

UK guidelines on oesophageal dilatation in clinical practice

Sarmed S Sami 1, Hasan N Haboubi 2, Yeng Ang 3,4, Philip Boger 5, Pradeep Bhandari 6, John de Caestecker 7, Helen Griffiths 8, Rehan Haidry 9, Hans-Ulrich Laasch 10, Praful Patel 5, Stuart Paterson 11, Krish Ragunath 12, Peter Watson 13, Peter D Siersema 14, Stephen E Attwood 15
PMCID: PMC5969363  PMID: 29478034

Abstract

These are updated guidelines which supersede the original version published in 2004. This work has been endorsed by the Clinical Services and Standards Committee of the British Society of Gastroenterology (BSG) under the auspices of the oesophageal section of the BSG. The original guidelines have undergone extensive revision by the 16 members of the Guideline Development Group with representation from individuals across all relevant disciplines, including the Heartburn Cancer UK charity, a nursing representative and a patient representative. The methodological rigour and transparency of the guideline development processes were appraised using the revised Appraisal of Guidelines for Research and Evaluation (AGREE II) tool.

Dilatation of the oesophagus is a relatively high-risk intervention, and is required by an increasing range of disease states. Moreover, there is scarcity of evidence in the literature to guide clinicians on how to safely perform this procedure. These guidelines deal specifically with the dilatation procedure using balloon or bougie devices as a primary treatment strategy for non-malignant narrowing of the oesophagus. The use of stents is outside the remit of this paper; however, for cases of dilatation failure, alternative techniques—including stents—will be listed. The guideline is divided into the following subheadings: (1) patient preparation; (2) the dilatation procedure; (3) aftercare and (4) disease-specific considerations. A systematic literature search was performed. The Grading of Recommendations Assessment, Develop­ment and Evaluation (GRADE) tool was used to evaluate the quality of evidence and decide on the strength of recommendations made.

Keywords: oesophageal strictures, oesophagitis, achalasia, dysphagia

Summary of recommendations

Patient preparation

  1. Predilatation investigations
    • 1.1 Obtain biopsy specimens from all strictures for histological analysis to exclude malignancy and eosinophilic oesophagitis (GRADE of evidence: moderate; strength of recommendation: strong).
    • 1.2 Repeat biopsy after cross-sectional imaging (computed tomography (CT) or endoscopic ultrasound (EUS)) in cases where biopsies are negative, but clinical or endoscopic features are atypical or suspicious for malignancy (GRADE of evidence: low; strength of recommendation: strong).
    • 1.3 Obtain oesophageal biopsy specimens in young patients with dysphagia or history of food impaction to exclude eosinophilic oesophagitis (GRADE of evidence: moderate; strength of recommendation: strong).
    • 1.4 Perform barium swallow in patients with suspected complex strictures (such as post-radiation therapy or history of caustic injury) in order to establish the location, length, diameter and number of strictures (GRADE of evidence: low; strength of recommendation: strong).
  2. Information and consent
    • 2.1 Counsel all patients about the benefits and risks of dilatation and the likely need for multiple sessions before symptom resolution can be achieved (GRADE of evidence: low; strength of recommendation: strong).
    • 2.2 Tailor information to the individual patient’s risk profile, based on the underlying cause, location, length and diameter of the stricture and coexistent adverse health problems (GRADE of evidence: low; strength of recommendation: strong).
    • 2.3 Provide all patients with written information on oesophageal dilatation before the procedure and obtain written, signed consent. Inform patients about the perforation risk and the potential need for endoscopic or operative intervention should a perforation occur (GRADE of evidence: low; strength of recommendation: strong).
    • 2.4 Inform patients— whenever appropriate—of any alternatives to dilatation, such as parenteral feeding or surgery in some cases (GRADE of evidence: low; strength of recommendation: strong).
    • 2.5 Do not perform oesophageal dilatation in patients with active or incompletely healed oesophageal perforation as it may extend the oesophageal defect and promote mediastinal soiling (GRADE of evidence: low; strength of recommendation: strong).
    • 2.6 Perform dilatation in patients with a recent, healed perforation; recent upper gastrointestinal surgery; pharyngeal or cervical deformity; or bleeding disorders after careful consideration of the benefits, risks and alternatives of the procedure (GRADE of evidence: low; strength of recommendation: strong).
  3. Fasting
    • 3.1 Advise patients to fast for at least 6 hours before the procedure in order to ensure emptying of the oesophagus and stomach. Patients with achalasia are likely to have oesophageal stasis and are therefore required to fast for a longer time based on the clinician’s judgement (GRADE of evidence: low; strength of recommendation: strong).
  4. Patient premedication
    • 4.1 Inform patients that dilatation is likely to be uncomfortable, in particular, when push dilators are used rather than dilatation balloons (GRADE of evidence: low; strength of recommendation: strong).
    • 4.2 Offer patients intravenous sedation with a benzodiazepine and an opioid analgesic as a minimum. Propofol sedation (delivered by a suitably qualified person), or a general anaesthetic are valid alternatives based on the clinician’s and patient’s preference, procedure complexity as well as local availability and expertise (GRADE of evidence: low; strength of recommendation: strong).

The dilatation procedure

  1. Personnel, training and equipment
    • 1.1 Oesophageal dilatation should be undertaken only by (or under direct supervision of) an experienced operator who performs sufficient numbers to maintain their skills. The operator should be supported by at least two assistants (one of whom must be a trained nurse) in the endoscopy/radiology room (GRADE of evidence: moderate; strength of recommendation: strong).
    • 1.2 Ensure that trainees performing dilatation have adequate knowledge and understanding of the indications for, contraindications to, and complications of, this therapeutic procedure. An understanding of the steps for recognition and management of complications is required. Trainees should be familiar with different dilatation techniques as well as alternative and complementary treatment options (GRADE of evidence: moderate; strength of recommendation: strong).
    • 1.3 Perform the procedure in a dedicated, fully equipped endoscopy room with access to X-ray screening and surgical support, or a similarly equipped radiological suite (GRADE of evidence: moderate; strength of recommendation: strong).
    • 1.4 Units must have an agreed protocol to follow in case of a perforation with clear identification of a qualified surgeon (on or off site) to manage this complication in cases where luminal treatment, such as a covered stent, is not feasible or appropriate (GRADE of evidence: low; strength of recommendation: strong).
  2. Oesophageal dilators
    • 2.1 Use either balloon or wire guided bougie dilators to perform oesophageal dilatation (GRADE of evidence: high; strength of recommendation: strong).
  3. The dilatation technique
    • 3.1 Consider limiting the initial dilatation to 10–12 mm in diameter (corresponding to 30–36F) in cases of very narrow strictures not passable by the adult gastroscope. The target for filiform strictures should be even lower (≤9 mm) (GRADE of evidence: very low; strength of recommendation: weak).
    • 3.2 Consider using no more than three successively larger diameter increments in a single session for both bougie and balloon dilators. The precise restriction of 3×1 mm diameter increments is not evidence based (GRADE of evidence: low; strength of recommendation: low).
    • 3.3 Use wire-guided (bougie or balloon) or endoscopically controlled (balloon) techniques for all patients to enhance safety (GRADE of evidence: moderate; strength of recommendation: strong).
    • 3.4 Do not use weighted (Maloney) bougies with blind insertion, because safer dilators are available (GRADE of evidence: high; strength of recommendation: strong).
    • 3.5 Perform dilatation without fluoroscopy for simple strictures as efficacy and safety have been shown in several studies (GRADE of evidence: moderate; strength of recommendation: strong).
    • 3.6 Use fluoroscopic guidance to enhance safety during dilatation of strictures that are either high risk (such as post-radiation and caustic); cannot be passed endoscopically and are long; angulated; or multiple (GRADE of evidence: moderate; strength of recommendation: strong).
    • 3.7 Perform repeat endoscopy or injection of contrast after dilatation in cases where perforation is suspected, to consider immediate treatment with a fully covered self-expanding metal stent (SEMS) (GRADE of evidence: low; strength of recommendation: strong).
    • 3.8 Use carbon dioxide insufflation instead of air during endoscopy whenever possible, in complex strictures to minimise luminal distension and postprocedural pain (GRADE of evidence: high; strength of recommendation: strong).
    • 3.9 Consider upper oesophageal sphincter dilatation in the treatment of dysphagia with disordered upper oesophageal sphincter opening, post-cricoid web, cricopharyngeal bar with or without the presence of a Zenker’s diverticulum, or to permit passage of radiofrequency ablation (RFA) catheters (GRADE of evidence: moderate; strength of recommendation: strong).
  4. Aftercare and follow-up
    • 4.1 Monitor patients for at least 2 hours in the recovery room and provide clear written instructions with advice on fluids, diet and medications after the procedure (GRADE of evidence: moderate; strength of recommendation: strong).
    • 4.2 Do not perform imaging and contrast studies routinely after the procedure, unless patients—during recovery—develop persistent chest pain, fever, breathlessness or tachycardia (GRADE of evidence: very low; strength of recommendation: weak).
    • 4.3 Ensure that patients are well and tolerating water on leaving the hospital (GRADE of evidence: low; strength of recommendation: strong).
    • 4.4 Suspect perforation when patients develop pain, breathlessness, fever or tachycardia. Transient chest pain is not uncommon following dilatation but persistent pain should prompt a CT scan with oral contrast to look for perforation (GRADE of evidence: low; strength of recommendation: strong).
    • 4.5 Perform endoscopic re-inspection if the patient becomes symptomatic while in the procedure room, in order to assess for the presence of perforation and to undertake treatment which may include immediate endoscopic stent placement (GRADE of evidence: low; strength of recommendation: strong).
    • 4.6 Provide patients with contact information for the on-call team should they experience chest pain, breathlessness or become unwell (GRADE of evidence: low; strength of recommendation: strong).
    • 4.7 Perform weekly or two-weekly dilatation sessions until easy passage of a ≥15 mm dilator is achieved along with symptomatic improvement (GRADE of evidence: moderate; strength of recommendation: strong).

Disease-specific considerations

  1. Achalasia dilatation
    • 1.1 Perform dilatation with pneumatic balloons 30–40 mm in diameter starting at 30 mm in the first session to reduce the risk of complications (GRADE of evidence: high; strength of recommendation: strong).
    • 1.2 Perform a second dilatation session 2–28 days later with a larger size balloon of 35 mm (GRADE of evidence: high; strength of recommendation: strong).
    • 1.3 Consider repeat dilatation (after the initial series) during follow-up to maintain symptom response (GRADE of evidence: high; strength of recommendation: strong).
    • 1.4 Perform dilatation under endoscopic or fluoroscopic control based on clinician’s preference and local expertise (GRADE of evidence: moderate; strength of recommendation: strong).
    • 1.5 Consider proton pump inhibitor (PPI) therapy after dilatation as the technique has 10–40% rate of symptomatic gastro-oesophageal reflux disease (GORD) or ulcerative oesophagitis after treatment (GRADE of evidence: high; strength of recommendation: strong).
    • 1.6 Consider performing a water-soluble contrast swallow after dilatation to screen for perforation, but it is not essential (GRADE of evidence: moderate; strength of recommendation: weak).
  2. Peptic strictures
    • 2.1 Offer PPI therapy to patients with GORD and dysphagia, as this treatment has been shown to reduce the need for oesophageal dilatation (GRADE of evidence: high; strength of recommendation: strong).
    • 2.2 Offer PPI therapy after endoscopic dilatation for peptic strictures in order to reduce recurrence rate (GRADE of evidence: high; strength of recommendation: strong).
    • 2.3 Offer PPI therapy rather than H2 receptor antagonists, which are ineffective in reducing the need for repeat dilatation (stricture recurrence), less effective in healing of oesophagitis and in providing symptom relief from GORD and dysphagia (GRADE of evidence: high; strength of recommendation: strong).
  3. Schatzki’s ring
    • 3.1 Do not offer dilatation for asymptomatic Schatzki’s rings incidentally discovered on diagnostic endoscopy or contrast studies (performed for unrelated indication) (GRADE of evidence: low; strength of recommendation: strong).
    • 3.2 Consider exclusion of eosinophilic oesophagitis by distal, mid and proximal oesophageal biopsies in symptomatic Schatzki’s ring (GRADE of evidence: moderate; strength of recommendation: strong).
    • 3.3 Offer a single dilatation session using graded dilatation to a relatively large diameter (16–20 mm) to treat dysphagia related to Schatzki’s ring (GRADE of evidence: moderate; strength of recommendation: strong).
    • 3.4 Offer PPI therapy after dilatation, as this reduces the risk of relapse of Schatzki’s ring (GRADE of evidence: moderate; strength of recommendation: strong).
    • 3.5 Consider electrosurgical incision as an effective alternative treatment to oesophageal dilatation for relieving dysphagia related to Schatzki’s ring (GRADE of evidence: high; strength of recommendation: strong).
  4. Post-endoscopic therapy strictures
    • 4.1 Inform patients of up to ~50% chance of developing symptomatic stricture requiring endoscopic dilatation after endoscopic resection (ER) either following endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) in any of the following situations: resection size >75% of the oesophageal circumference; and a longitudinal resection length of >40 mm (GRADE of evidence: high; strength of recommendation: strong).
    • 4.2 Offer dilatation for the management of symptomatic post-mucosal resection strictures (GRADE of evidence: moderate; strength of recommendation: strong).
    • 4.3 Inform patients that perforation rates of dilatation for post-ER strictures in the oesophagus can be up to 1.1% (GRADE of evidence: moderate; strength of recommendation: strong).
    • 4.4 Offer fully covered SEMS in carefully selected patients for the dilatation of refractory strictures after ER (GRADE of evidence: low; strength of recommendation: weak).
    • 4.5 Consider steroid injection at the resection site or oral prednisolone therapy in patients at high risk after large EMR or ESD to reduce stricture formation (GRADE of evidence: moderate; strength of recommendation: weak).
    • 4.6 Offer fully covered SEMS in carefully selected patients for the prevention of refractory strictures after ESD of large lesions, placing the stent at the same time as the first stricture dilatation (GRADE of evidence: moderate; strength of recommendation: weak).
    • 4.7 Inform patients that stricture formation requiring dilatation is significantly higher in the following situations: after photodynamic therapy (PDT) (36%) compared with other forms of ablation; where ER has preceded ablation (12% vs 6%); with use of higher doses of energy with RFA for Barrett’s oesophagus (BO); and after RFA for early squamous cell neoplasia (14–23%) (GRADE of evidence: moderate; strength of recommendation: strong).
    • 4.8 Offer dilatation in patients with clinically significant stricture formation after RFA, with or without previous ER (GRADE of evidence: moderate; strength of recommendation: strong).
    • 4.9 Offer PPI therapy after ER or ablation to reduce stricture occurrence (GRADE of evidence: low; strength of recommendation: strong).
  5. Eosinophilic oesophagitis
    • 5.1 Offer dilatation along with other forms of disease modification using diet, topical steroids or other drugs (GRADE of evidence: moderate; strength of recommendation: strong).
    • 5.2 Start other treatments for eosinophilic oesophagitis (EoE) before dilatation if possible, and those may be continued afterwards to prevent or delay recurrence of symptoms (GRADE of evidence: moderate; strength of recommendation: strong).
    • 5.3 Offer preliminary topical steroids followed by dilatation as this is more cost-effective than using dilatation alone as first-line treatment (GRADE of evidence: moderate; strength of recommendation: strong).
    • 5.4 Offer dilatation as first-line treatment in patients with acute symptoms such as food bolus obstruction and daily dysphagia (GRADE of evidence: moderate; strength of recommendation: strong).
    • 5.5 Offer dilatation to patients with established tight stricture, narrow calibre oesophagus and those who do not respond to diet or drugs (GRADE of evidence: high; strength of recommendation: strong).
    • 5.6 Reassure patients that dilatation of EoE is no more dangerous than dilatation for other oesophageal diseases, and the perforation rates are similar (GRADE of evidence: high; strength of recommendation: strong).
    • 5.7 Inform patients with EoE that chest pain after dilatation is common (GRADE of evidence: high; strength of recommendation: strong).
    • 5.8 Inform patients that symptom response after dilatation usually lasts up to 1 year (GRADE of evidence: moderate; strength of recommendation: strong).
    • 5.9 Repeat dilatation if needed (GRADE of evidence: high; strength of recommendation: strong).
    • 5.10 Consider the use of special techniques such as EndoFLIP and Balloon pull through to judge the optimal calibre and position of dilatation (GRADE of evidence: low; strength of recommendation: weak).
  6. Postoperative strictures
    • 6.1 Consider performing upper GI endoscopy, manometry, pH studies and barium swallow first in patients with post-fundoplication dysphagia, to understand the mechanism of dysphagia before dilatation or repeat surgery (GRADE of evidence: low; strength of recommendation: weak).
    • 6.2 Consider treatment of concurrent delayed gastric emptying in order to reduce the need for redilatations (GRADE of evidence: low; strength of recommendation: weak).
    • 6.3 Consider the use of balloon dilatation to 30–40 mm (as with achalasia) in patients with post-Nissen dysphagia (GRADE of evidence: low; strength of recommendation: weak).
    • 6.4 Use steroid injections (0.5 mL aliquots of triamcinolone 40 mg/mL to the four quadrants) to reduce the frequency of repeat dilatations in anastomotic strictures refractory to initial dilatation approaches. This can be performed with a 4mm-long, 23-gauge needle immediately before bougie dilatation while leaving the needle in for at least 1 min to minimise leakage of the drug and ensure delivery of the full dose to the target area (GRADE of evidence: moderate; strength of recommendation: weak).
    • 6.5 Consider using needle knife incision for anastomotic strictures as an alternative to dilatation (GRADE of evidence: moderate; strength of recommendation: weak).
  7. Post-radiation strictures
    • 7.1 Consider a combined anterograde and retrograde dilatation (CARD) or rendezvous approach under general anaesthetic as an alternative to surgery in treatment of the completely obstructed oesophagus, where local expertise is available (GRADE of evidence: moderate; strength of recommendation: weak).
    • 7.2 Use fluoroscopic guidance to assist with the rendezvous procedure (GRADE of evidence: moderate; strength of recommendation: strong).
    • 7.3 Use a guidewire to navigate through the obstruction when using the CARD approach to re-establish luminal patency (GRADE of evidence: low; strength of recommendation: strong).
    • 7.4 After gaining luminal patency using the CARD procedure, perform subsequent dilatation using either balloon or bougie (GRADE of evidence: moderate; strength of recommendation: strong).
  8. Caustic strictures
    • 8.1 Perform upper gastrointestinal tract endoscopy within the first 12–48 hours after caustic ingestion (GRADE of evidence: moderate; strength of recommendation: strong).
    • 8.2 Ensure timely management of oesophageal strictures with dilatation as this plays a key role in affecting patient outcomes (GRADE of evidence: moderate; strength of recommendation: strong).
    • 8.3 Consider avoiding dilatation within 3 weeks of initial caustic ingestion (GRADE of evidence: low; strength of recommendation: weak).
    • 8.4 Consider a time interval between dilatations of <2 weeks (GRADE of evidence: very low; strength of recommendation: weak).
  9. Refractory strictures
    • 9.1 Inform patients about the lack of good quality evidence for best approach to treatment of refractory strictures (GRADE of evidence: low; strength of recommendation: strong).
    • 9.2 Consider discussion with, and/or referral to, centres with expertise in treatment and follow-up of patients with refractory strictures (GRADE of evidence: low; strength of recommendation: weak).
    • 9.3 Ensure optimal management of ongoing inflammation with high-dose PPI therapy before defining a stricture as refractory (GRADE of evidence: high; strength of recommendation: strong).
    • 9.4 Consider alternative neuromuscular causes in patients with ongoing dysphagia despite a seemingly adequate oesophageal diameter (GRADE of evidence: low; strength of recommendation: strong).
    • 9.5 Use fluoroscopic guidance during dilatation of refractory oesophageal strictures (GRADE of evidence: very low; strength of recommendation: weak).
    • 9.6 Use either bougie or balloon dilators with the decision individualised on a case by case basis dependent on the nature (length, location, cause) of the stricture (GRADE of evidence: low; strength of recommendation: weak).
    • 9.7 Use intralesional steroid therapy combined with dilatation in refractory strictures with evidence of inflammation (macro- or microscopically) on the assumption that anti-reflux therapy has been maximised previously with no benefit (GRADE of evidence: high; strength of recommendation: strong).
    • 9.8 Consider incisional therapy in patients with refractory Schatzki’s rings and anastomotic strictures at centres experienced in the use of such techniques (GRADE of evidence: very low; strength of recommendation: weak).
    • 9.9 Offer temporary placement of fully covered self-expanding removable stents in patients where previous methods have been unsuccessful in maintaining adequate oesophageal patency (GRADE of evidence: low; strength of recommendation: weak).
    • 9.10 The optimum duration of stent placement is usually between 4 and 8 weeks, but may vary depending on stricture aetiology and length, and type of stent (GRADE of evidence: very low; strength of recommendation: weak).
    • 9.11 Consider biodegradable stent placement to reduce the frequency of dilatation in selected cases (GRADE of evidence: low; strength of recommendation: weak).
    • 9.12 Consider teaching selected, self-motivated patients, with short proximal strictures to self-bougienage (GRADE of evidence: very low; strength of recommendation: weak).
    • 9.13 Offer surgery to patients who do not respond or are intolerant to other measures (GRADE of evidence: low; strength of recommendation: weak).

Introduction

Oesophageal dilatation is indicated in the treatment of symptomatic narrowing of the oesophagus, which may develop from of a wide range of anatomical and functional oesophageal disorders. The formation of benign strictures of the oesophagus is the end result of oesophageal inflammation and ulceration, which leads to deposition of collagen fibres that contract over time and cause narrowing of the oesophageal lumen.1 Reflux-induced strictures used to be a frequent indication for dilatation, but the increasing use of proton pump inhibitors (PPIs) has led to a relative decrease in their incidence.2 Other important causes of strictures include postoperative, post-endoscopic therapy (such as endoscopic resection (ER) and ablation), eosinophilic oesophagitis, post-radiation and corrosive strictures, as well as rings and webs.2–4 The characteristic symptom is dysphagia to solids more than liquids, in contrast to those with oesophageal motility disorders, in whom dysphagia to both solids and liquids occurs.1 In the latter group, dilatation does not consistently improve symptoms, with the exception of achalasia for which oesophageal dilatation is an effective treatment.5 The primary aim of oesophageal dilatation is to alleviate symptoms, permit maintenance of oral nutrition and reduce the risk of pulmonary aspiration.

Guideline development

This guideline is endorsed by the Clinical Services and Standards Committee of the British Society of Gastroenterology (BSG) under the auspices of the oesophageal section of the BSG. It has been extensively updated and modified since the original version published in 2004. The methodology and reporting of the guideline were developed according to recommendations by BSG and the National Institute for Health and Care Excellence (NICE) with strict adherence to the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument as detailed below.

Assessing the quality of guidelines: AGREE II instrument

The purpose of the AGREE II instrument is to provide a framework to assess the quality of the guideline, provide a methodological strategy for its development and inform the reporting process of the guideline. It includes the following six domains which were used by our guideline development group (GDG): scope and purpose, stakeholder involvement, rigour of development, clarity and presentation, applicability and editorial independence.

Scope and purpose

This guideline will focus on the oesophageal dilatation procedure as a primary treatment for benign narrowing of the oesophagus using push or balloon dilators in adult patients (≥18 years). Palliative treatment of malignant strictures and the use of stents as a primary treatment option are outside the scope of this guideline, but their role in dilatation failure will be discussed.6 Our objective is to provide a practical, evidence-based, guide for clinicians (gastroenterologists, upper GI surgeons, radiologists and non-medical endoscopists) on how to undertake oesophageal dilatation, as well as pre- and postprocedure considerations in order to maximise safety and efficacy in patients with dysphagia. This document is intended for use once a decision to perform oesophageal dilatation has been made. This decision ultimately resides with the caring clinician after discussion with the patient.

As the practice of pure radiological dilatation is appropriate in some circumstances but not always advantageous for reasons of convenience, the term endoscopist and endoscopic dilatation can sometimes be interchanged with radiologist and radiological dilatation throughout this document. The decision should rest with a team approach by endoscopists and radiologists in each centre.

In addition to description of the dilatation procedure, specific aspects of management for different types of strictures will also be covered. This will include peptic strictures, post-endoscopic therapy (such as endoscopic resection and ablation), eosinophilic oesophagitis, anastomotic, post-radiation and corrosive strictures as well as rings and webs. The dilatation procedure for oesophageal achalasia will also be described.

Stakeholder involvement

The GDG included individuals who are representative of all the relevant professional groups, including gastroenterologists (including one international expert), an upper GI surgeon, a radiologist and a nurse endoscopist. We also included a patient representative (who had had several dilatations for strictures and a perforation) and the chair of a relevant patient charity (Heartburn Cancer UK). All views were actively sought and incorporated in the guideline at every stage of its development through regular meetings and teleconference discussions.

Rigour of development

A systematic literature search strategy was developed with the aid of an expert librarian. We searched MEDLINE, Embase and the Cochrane Central Register of Controlled Trials (CENTRAL), from the database inception through to 31 October 2015 and updated 1 January 2017. Other sources searched included reference lists of identified primary journal articles. All the guideline questions were designed in PICO (Problem/population, Intervention, Comparator, Outcome) format and incorporated into an extensive search strategy (online supplementary appendix 1) using all possible combination of search terms (both as free text and—where applicable—as Medical Subject Headings). No language limits were applied. The search results were divided among GDG members, who independently screened titles and abstracts relevant to their writing sections (two members for each section). Studies were included if they reported data on any aspect of the dilatation procedure that is relevant to the guideline scope and purpose.

Supplementary file 1

gutjnl-2017-315414supp001.pdf (395.9KB, pdf)

The quality of included evidence was assessed using the Grading of Recommendations Assessment, Develop­ment and Evaluation (GRADE) system, which specifically separates the strength of evidence from the strength of a recommendation. While the strength of a recommendation may often reflect the evidence base, the GRADE system allows for occasions where this is not the case—for example, where it seems good sense to make a recommendation despite the absence of high-quality scientific evidence such as a large randomised controlled trial (table 1).

Table 1.

An overview of the GRADE system278

GRADE—strength of evidence GRADE—strength of recommendation
High quality: Further research is very unlikely to change our confidence in the estimate of effect The trade-offs: Taking into account the estimated size of the effect for main outcomes, the confidence limits around those estimates and the relative value placed on each outcome
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate The quality of the evidence
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate Translation of the evidence into practice in a particular setting: Taking into consideration important factors that could be expected to modify the size of expected effects
Very low quality: Any estimate of effect is very uncertain Uncertainty about the baseline risk for the population of interest

To achieve transparency and simplicity, the GRADE system classifies the quality of evidence in one of four levels—high, moderate, low and very low (table 1). Evidence based on randomised controlled trials begins as high-quality evidence, but our confidence in the evidence may be decreased for several reasons, including: study limitations; inconsistency of results; indirectness of evidence; imprecision; reporting bias. The GRADE system offers two grades of recommendations: ‘strong’ and ‘weak’. When the desirable effects of an intervention clearly outweigh the undesirable effects, or clearly do not, guideline panels offer strong recommendations. On the other hand, when the trade-offs are less certain—either because of low-quality evidence or because evidence suggests that desirable and undesirable effects are closely balanced—weak recommendations become mandatory. In addition to the quality of the evidence, several other factors affect whether recommendations are strong or weak, such as: uncertainty about the balance between desirable and undesirable effects, uncertainty or variability in values and preferences and uncertainty about whether the intervention represents a wise use of resources.

Areas of disagreement on the recommendation grade were resolved by discussion, using a Delphi process. The guideline drafts and final manuscript were critically reviewed by an international expert (PDS) to ensure broader applicability and rigour. It is expected that a review and updating of this guideline will be required in 5 years in order to account for new developments.

Clarity and presentation

We formulated recommendations that are specific and unambiguous. We considered both the general procedure of dilatation and specific aspects of stricture management according to the underlying health problem. Key recommendations are summarised at the beginning of the document.

Applicability

We do not expect any barriers or resource implications to the implementation of this guideline, because described assessment and treatment techniques are already being performed in clinical practice. We will provide a quick reference guide and suggest a minimum requirement for procedure documentation in order to facilitate audit and monitoring of outcomes in individual units.

Editorial independence

GDG members have declared their conflicts of interest. The views of any funding body did not influence the content of this guideline.

Patient preparation

Oesophageal dilatation is best undertaken as a planned procedure in patients who have been appropriately investigated, prepared and consented. An assessment of the patient’s nutritional status and referral to a dietician should also be considered.

Predilatation investigations

(a) Should all strictures be biopsied before dilatation?

  • Obtain biopsy specimens from all strictures for histological analysis to exclude malignancy and eosinophilic oesophagitis7–9 (GRADE of evidence: moderate; strength of recommendation: strong).

Obtaining a definitive diagnosis before dilatation is desirable, because this will influence the overall management and estimation of perforation risk.8–10 Oesophageal biopsy samples can be safely obtained immediately before oesophageal dilatation7; however, if the stricture is tight or when the endoscopic features suggest malignancy, the results of biopsies are best awaited.4

  • Repeat biopsy after cross-sectional imaging (CT or with endoscopic ultrasound (EUS) in cases where biopsies are negative, but clinical or endoscopic features are atypical or suspicious for malignancy11 (GRADE of evidence: low; strength of recommendation: strong).

EUS may be a more sensitive test than CT, but passage of the EUS probe is often not successful in the case of a stricture.11

  • Obtain oesophageal biopsy specimens in young patients with dysphagia or history of food impaction to exclude eosinophilic esophagitis8 9 (GRADE of evidence: moderate; strength of recommendation: strong).

(b) Are there any other recommended tests?

  • Perform barium swallow in patients with suspected complex strictures (such as post-radiation therapy or history of caustic injury) in order to establish the location, length, diameter and number of strictures12 13 (GRADE of evidence: low; strength of recommendation: strong).

Barium swallow is also useful to evaluate the presence of associated pathology such as an oesophageal diverticulum or a hiatus hernia.12 13 This information will aid selection of the dilating technique, estimation of the number of sessions required and counselling the patient about the expected risks.13

Information and consent

The overall consent process should be in line with the published BSG guidance.14

(a) What information should patients be given?

  • Counsel all patients about the benefits and risks of dilatation and the likely need for multiple sessions before symptom resolution can be achieved (GRADE of evidence: low; strength of recommendation: strong).

  • Tailor information to the individual patient’s risk profile, based on the underlying cause, location, length and diameter of the stricture and coexistent adverse health problems (GRADE of evidence: low; strength of recommendation: strong).

Our patient representatives suggested that the use of a diagram to illustrate the location, length and shape of the stricture is desirable to enhance the patient’s understanding of the procedure. Moreover, the presence of a relative or a caregiver should be encouraged if deemed appropriate during the consent process.

  • Provide all patients with written information on oesophageal dilatation before the procedure and obtain written, signed consent. Inform patients about the perforation risk and the potential need for endoscopic or operative intervention should a perforation occur (GRADE of evidence: low; strength of recommendation: strong).

  • Inform patients— whenever appropriate—of any alternatives to dilatation, such as parenteral feeding or surgery in some cases (GRADE of evidence: low; strength of recommendation: strong).

(b) What are the possible complications?

Complications include pulmonary aspiration, bleeding, perforation, risks of sedation and chest pain15; the last of these being more common in patients with eosinophilic oesophagitis.16 17 A UK regional audit published in 1995 reported an overall perforation rate of 2.6% with a 30-day mortality of 1%.10 Perforation was less common following dilatation of benign strictures (1.1% with a mortality of 0.5%) than following dilatation and/or intubation of malignant strictures (6.4% with a mortality of 2.3%).10 The risk of perforation was greater with less experienced endoscopists (performed <500 previous diagnostic endoscopies).10 Hernandez et al reported a perforation rate of 4 out of 348 procedures (1.1%); however, all these four perforations occurred when Maloney dilators (non-wire guided) were passed blindly into complex strictures. No perforations occurred with Savary-Gilliard (wire-guided) and balloon dilators.12 Hagel et al reported the most recent large retrospective case series of 1497 procedures on 368 patients over a 10-year period. Operators used Savary-Gilliard bougies (Cook Medical, Bloomington, Indiana, USA) or through the scope (TTS) balloons (Controlled Radial Expansion, CRE, Boston Scientific Ltd, Cork, Ireland and Eclipse Wire Guided Balloon Dilators, Cook Ireland Ltd, Limerick Ireland). Eight perforations (0.53%) occurred in malignant, post-radiation or caustic strictures. No perforations were reported in other types of strictures, such as peptic, postoperative and eosinophilic oesophagitis.18

The reported risk of perforation in achalasia has varied widely across studies from 0% to 8% (2–4% in most studies) with a mortality of 0–1%.19 20 Katzka et al 19 pooled data from all 25 studies in the literature and reported a perforation rate of 2%; however, the balloon size, pressure, dilatation times and single or multiple dilatations varied in almost every study. The perforation rate is lower with a graded approach to balloon dilatation and in experienced hands.20

(c) What are the contraindications/cautions for stricture dilatation?

  • Do not perform oesophageal dilatation in patients with active or incompletely healed oesophageal perforation as it may extend the oesophageal defect and promote mediastinal soiling3 4 (GRADE of evidence: low; strength of recommendation: strong).

  • Perform dilatation in patients with a recent, healed perforation; recent upper gastrointestinal surgery; pharyngeal or cervical deformity; or bleeding disorders after careful consideration of the benefits, risks and alternatives of the procedure3 4 (GRADE of evidence: low; strength of recommendation: strong).

Dilatation may be performed in patients who are having concurrent radiotherapy.3 4

Fasting

  • Advise patients to fast for at least 6 hours before the procedure in order to ensure emptying of the oesophagus and stomach. Patients with achalasia are likely to have oesophageal stasis and are therefore required to fast for a longer time based on the clinician’s judgement3 4 (GRADE of evidence: low; strength of recommendation: strong).

Patient premedication

  • Inform patients that dilatation is likely to be uncomfortable, in particular, when push dilators are used rather than dilatation balloons (GRADE of evidence: low; strength of recommendation: strong).

  • Offer patients intravenous sedation with a benzodiazepine and an opioid analgesic as a minimum. Propofol sedation (delivered by a suitably qualified person), or a general anaesthetic are valid alternatives based on the clinician’s and patient’s preference, procedure complexity, as well as local availability and expertise (GRADE of evidence: low; strength of recommendation: strong).

Patients taking anticoagulants or antiplatelet agents and those at risk of endocarditis

UK-based clinicians must adhere to the BSG and NICE guidelines on management of anticoagulation and antibiotic prophylaxis during endoscopy.21 22 Clinicians in other countries should follow the corresponding guidelines in their country or region of practice.22–24

The dilatation procedure

Personnel, training and equipment

(a) Who should perform dilatation?

  • Oesophageal dilatation should only be undertaken only by (or under direct supervision of) an experienced operator who performs sufficient numbers to maintain their skills. The operator should be supported by at least two assistants (one of whom must be a trained nurse) in the endoscopy/radiology room4 25 26 (GRADE of evidence: moderate; strength of recommendation: strong).

The specific number of dilatation procedures required each year to maintain the operator’s skills remains unknown. It is good practice for independent operators to audit their outcomes and be regularly involved in the care of patients with upper GI disorder. Professional bodies such as Joint Advisory Group on Gastrointestinal Endoscopy (JAG) may define the suitable number of procedures for training and maintenance of practice standards.

  • Ensure that trainees performing dilatation have adequate knowledge and understanding of the indications for, contraindications to, and complications of, this therapeutic procedure. An understanding of the steps for recognition and management of complications is required. Trainees should be familiar with different dilatation techniques as well as alternative and complementary treatment options27 (GRADE of evidence: moderate; strength of recommendation: strong).

It is estimated that less experienced endoscopists (who have performed fewer than 500 diagnostic upper endoscopy procedures) are four times more likely to cause a perforation than their more experienced colleagues.10 In the UK, the JAG stipulates that training on therapeutic endoscopy should be undertaken only after competency in diagnostic procedures is achieved (minimum of 300 procedures) and the former should take place under direct supervision.27 No formal guidelines exist for interventional radiologists, but a similar level of experience in diagnostic and interventional procedures is recommended. Close collaboration of the radiologists with interventional endoscopists and upper GI surgeons is essential for the appropriate management of complications.

Appropriate staffing and equipment are important for the provision of safe and successful therapeutic endoscopy procedures. Poor staffing levels are associated with worse outcomes from dilatation.10 Procedural assistants should be familiar with the dilatation equipment and capable of helping the operator in cases of an emergency. Qualified radiographers must be present when the procedure is performed under X-ray screening.4 10 25

(b) Where should the procedure be performed?

  • Perform the procedure in a dedicated, fully equipped endoscopy room with access to x-ray screening and surgical support,10 25 or a similarly equipped radiological suite (GRADE of evidence: moderate; strength of recommendation: strong).

  • Units must have an agreed protocol to follow in case of a perforation with clear identification of a qualified surgeon (on or off site) to manage this complication in cases where luminal treatment, such as a covered stent, is not feasible or appropriate6 10 (GRADE of evidence: low; strength of recommendation: strong).

Access to radiographic screening must be available to assist dilatation if there are difficulties in passing a guidewire or balloon catheter through the stricture.25 When a perforation occurs, prompt treatment should be started and the relevant surgical team must be informed immediately.25

Oesophageal dilators

There are two types of oesophageal dilators: the push (bougie) dilator and the balloon dilator.

Push dilators

Push dilators are either wire guided (metal olives, Celestin-type dilators or polyvinyl bougies) or non-wire guided (tungsten-filled weighted rubber bougies).28

Several models of wire-guided bougie dilators are available. The Savary-Gilliard (Cook Medical, Winston-Salem, North Carolina, USA) dilators are polyvinyl chloride, latex-free cylindrical solid tubes with a central channel to accommodate the guidewire. They are the most widely used (5–20 mm diameter). Each dilator has a 20 cm tapered tip and a radio-opaque band at the widest point of the dilator to aid radiological localisation. American Dilatation System (ConMed, Utica, New York, USA) and SafeGuide dilators (Medovations, Milwaukee, USA) are similar, but are totally radio-opaque throughout their length.28 Bougie dilators have external markers indicating the distance from the tip (American System) or from the point of maximal diameter (Savary-Gilliard) or both (SafeGuide). The InScope Optical Dilator (Ethicon Endosurgery Inc, Blue Ash, Ohio, USA) is a flexible, transparent, bougie with three dilating segments fitted over a standard endoscope to allow sequential dilatation under direct vision, but data on its efficacy are scarce.29 The Eder-Puestow dilators comprise a series of graduated metal olives (6.6–19.3 mm diameter) mounted on a flexible shaft. At one time, this was the only system available for dilating complex or resistant strictures, but is now rarely used.

Non-wire-guided weighted bougies are passed blindly after the application of local anaesthetic while the patient is in a sitting position. This approach has been used for self-dilatation in carefully selected patients, but it is seldom used now owing to concerns about safety.28 The Maloney dilator was the most commonly used. It has a tapered tip and is available in multiple sizes. Older versions were internally weighted with mercury, which has now been replaced by tungsten because of concerns about leakage and disposal of mercury.

Balloon dilators

Through the scope (TTS) balloon dilators are available in a variety of designs, lengths and diameters from various manufacturers. They are designed to pass through the endoscope with or without wire guidance so that dilatation can be observed. The balloon is made of low-compliance, inflatable, thermoplastic polymers that allow uniform and reproducible expansion to the specified diameter. Most balloons allow for sequential expansion to multiple diameters. Larger ranges of wire-guided balloons are available for non-endoscopic dilatation under fluoroscopy. The balloon size needs to be carefully matched to the size of the stricture (see below). Dilating balloons are expanded by pressure injection of liquid (eg, water, radio-opaque contrast) using a handheld accessory device. Inflation with radio-opaque contrast allows for fluoroscopic observation. The hydraulic pressure of the balloon is monitored manometrically to gauge the radial expansion force. Balloon dilators are single-use only.28

For achalasia dilatation, large-diameter (30, 35 and 40 mm) polyethylene balloon dilators with radio-opaque markers are used.28 They are all wire-guided, single use, and do not pass through the endoscope. They are positioned using fluoroscopic guidance, and balloon insufflation pressure is monitored manometrically.28

(a) Is there a difference in clinical outcomes between balloons and bougie dilators?

  • Use either balloon or wire-guided bougie dilators to perform oesophageal dilatation30–32 (GRADE of evidence: high; strength of recommendation: strong).

There is no difference in clinical outcomes—in particular, safety and efficacy, between wire-guided bougie and balloon dilators. Hence the choice should be based on clinician’s preference, local expertise, equipment availability, cost and the availability of robust methods of decontamination of reusable medical devices as many push dilators are not single use.30–32

Three randomised controlled trials compared these two techniques and found no difference in efficacy for dysphagia relief or safety at 1 year. Another retrospective study compared Maloney, balloon-type (both the hydrostatic and pneumatic type) and Savary-Gilliard dilators in 102, 156 and 90 sessions, respectively. The risk of oesophageal perforation was higher with Maloney dilators when passed, blindly, into complex strictures; hence they should be avoided in these cases, and in patients with a tortuous oesophagus and large hiatus hernia.12 Savary-Gilliard and balloon dilators are currently the most frequently used.28 Although balloon dilators allow the procedure to be performed under direct vision, they are more costly than push dilators28 but there is no direct cost-effectiveness comparison of the two techniques in clinical practice.

The dilatation technique

This section describes the general technique of benign stricture dilatation. Achalasia dilatation and disease-specific considerations will be discussed in subsequent sections.

Strictures can be simple or complex.33 34 Simple strictures are short (<2 cm), concentric, straight, and allow the passage of a normal diameter endoscope.33 34 Examples include Schatzki’s rings, oesophageal webs and peptic strictures.33 34 Overall, one to three dilatation sessions are sufficient to relieve dysphagia in simple strictures. Only 25–35% of patients require additional sessions, with a maximum of five dilatations in >95% of patients.35 Complex strictures are usually longer (≥2 cm), angulated, irregular or have a severely narrowed diameter.33 34 These are more difficult to treat and have a tendency to be refractory or to recur despite dilatation.

(a) What size dilator should be initially chosen?

The initial dilator choice should be based on the known or estimated stricture diameter, length and the underlying pathology.

  • Consider limiting the initial dilatation to 10–12 mm in diameter (corresponding to 30–36F) in cases of very narrow strictures not passable by the adult gastroscope. The target for filiform strictures should be even lower (≤9 mm) (GRADE of evidence: very low; strength of recommendation: weak).

(b) What is the recommended number of dilatations or size increments per session?

  • Consider using no more than three successively larger diameter increments in a single session for both bougie and balloon dilators. The precise restriction of 3×1 mm diameter increments is not evidence based3 4 36 (GRADE of evidence: low; strength of recommendation: low).

Although a ‘rule of three’ is recommended by many practice guidelines and authorities,3 4 no studies have demonstrated improvement in safety or efficacy with this approach. On the other hand, a recent retrospective study showed that non-adherence to the rule of three did not appear to increase the risk of adverse events, particularly perforation, after oesophageal dilatation using bougie dilators, except for malignant strictures.36 For very tight or long strictures, it may be safer to limit the initial dilatation to one or two size increments (2×1 mm) only. Conversely, larger increments may be safely used (4×1 mm or 3×2 mm) in less tight strictures or in those which have completely recurred after the first dilatation session.37 Patients usually need several sessions to achieve resolution of dysphagia and they should be informed of this possibility before the first procedure.

(c) The need for wire guidance or endoscopic control?

  • Use wire-guided (bougie or balloon) or endoscopically controlled (balloon) techniques for all patients to enhance safety18 38–40 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Do not use weighted (Maloney) bougies with blind insertion, because safer dilators are available41 (GRADE of evidence: high; strength of recommendation: strong).

(d) What is the role of fluoroscopy in stricture dilatation?

  • Perform dilatation without fluoroscopy for simple strictures as efficacy and safety have been shown in several studies18 38–40 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Use fluoroscopic guidance to enhance safety during dilatation of strictures that are either high risk (such as post-radiation and caustic); cannot be passed endoscopically and are long; angulated; or multiple18 38–40 (GRADE of evidence: moderate; strength of recommendation: strong).

The use of radiographic screening in non-simple strictures gives additional assurance and control of the dilatation process. During wire-guided dilatation, it demonstrates that the wire has passed the stricture, and kinking of the wire has not occurred within or distal to the stricture. Fluoroscopy also shows that the dilator is following the line of the oesophageal lumen. During balloon dilatation, it indicates whether the balloon has slipped during inflation and whether obliteration of the stricture waist has occurred.3 4

Radiographic screening is particularly helpful when the stricture is tortuous or complex or associated with a large hiatus hernia or a diverticulum. It may also be of value when the guidewire meets resistance during passage through the stricture or when an adequate length of wire cannot be passed distal to the stricture. Although comparative trials are not available, the selective use of radiological screening appears safe and effective and is supported by extensive clinical experience.42 43 The use of small calibre gastroscopes should also be considered in narrow strictures.

  • Perform repeat endoscopy or injection of contrast after dilatation in cases where perforation is suspected, to consider immediate treatment with a fully covered self-expandable metal stent6 (GRADE of evidence: low; strength of recommendation: strong).

  • Use carbon dioxide insufflation instead of air during endoscopy whenever possible, in complex strictures to minimise luminal distension and postprocedural pain44 (GRADE of evidence: high; strength of recommendation: strong).

Upper oesophageal sphincter disturbances, including motor disorders and mechanical disorders, can result in symptoms of dysphagia.45 Pathologies associated with disordered neurally mediated opening of the upper oesophageal sphincter, including oculopharyngeal muscular dystrophies, may be amenable to dilatation to relieve symptoms.46 Furthermore, while a cricopharyngeal bar is often an incidental radiological finding in cricopharyngeal fibrosis, treatment of associated dysphagia by both balloon and bougie dilatation methods can be successful.47

  • Consider upper oesophageal sphincter dilatation in the treatment of dysphagia with disordered upper oesophageal sphincter opening, post-cricoid web, cricopharyngeal bar with or without the presence of a Zenker’s diverticulum, or to permit passage of radiofrequency ablation (RFA) catheters45–53 (GRADE of evidence: moderate; strength of recommendation: strong).

Aftercare and follow-up

(a) Postprocedure and discharge instructions

  • Monitor patients for at least 2 hours in the recovery room and provide clear written instructions with advice on fluids, diet and medications after the procedure10 25 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Do not perform imaging and contrast studies routinely after the procedure, unless patients— during recovery—develop persistent chest pain, fever, breathlessness or tachycardia (GRADE of evidence: very low; strength of recommendation: weak).

  • Ensure that patients are well and tolerating water on leaving the hospital4 (GRADE of evidence: low; strength of recommendation: strong).

  • Suspect perforation when patients develop pain, breathlessness, fever or tachycardia.15 Transient chest pain is not uncommon following dilatation but persistent pain should prompt a CT scan with oral contrast to look for perforation54 (GRADE of evidence: low; strength of recommendation: strong).

A chest X-ray examination may show pneumothorax, pneumomediastinum, air under the diaphragm or a pleural effusion but normal appearances do not exclude perforation. If clinical suspicion is high or if endoscopy examination raises the possibility of a deeper laceration than just mucosal, then ideally a CT scan with oral contrast should be performed. Conventional contrast studies are less sensitive and may miss small perforations.54–56 Moreover, CT can detect other complications, such as pleural effusions, pneumopericardium and pneumoperitoneum.57

  • Perform endoscopic re-inspection if the patient becomes symptomatic while in the procedure room, in order to assess for the presence of perforation and to undertake treatment which may include immediate endoscopic stent placement6 (GRADE of evidence: low; strength of recommendation: strong).

Iatrogenic perforation is a medical emergency. The patient should be assessed by an experienced physician and experienced surgeon in order to formulate an appropriate plan, which may include surgical, endoscopic or conservative management.4

  • Provide patients with contact information for the on-call team should they experience chest pain, breathlessness or become unwell4 (GRADE of evidence: low; strength of recommendation: strong).

(b)Timing of next follow-up and procedure end points

The timing of subsequent dilatation sessions may depend on the degree of success of initial dilatation and the patient’s response to the procedure. Patients often require multiple sessions, especially if the stricture has a narrow diameter or any complex features.58 In the majority of studies, a repeat procedure was performed after 1 week and a subsequent follow-up at 2–4 weeks.31 59 In some patients, however, symptoms tend to recur rapidly following dilatation, hence they may require more frequent weekly or biweekly dilatations based on symptoms and stricture resolution.3 4

As a general rule, the last dilator size used in the previous session must be passed first. However, the degree of fibrosis and stricture healing is unpredictable and not all patients are expected to tolerate passage of the largest diameter dilator used during the previous session. Reassessment of stricture diameter is required and a smaller size dilator may be used if deemed appropriate.

Most patients respond well to oesophageal dilatation but outcomes are influenced significantly by the underlying pathology, with better clinical response rates achieved in peptic and post-surgical strictures than in caustic and post-radiation pathology.43

There is no consensus on the definition of end point for dilatation. In one case series of 321 patients, 98% of those in whom a 15 mm (45F) dilator was inserted, achieved clinical response over a mean follow-up period of 18.8 months.43 In one prospective study, all patients underwent dilatation to 15 mm then were randomised to either a subjective (end point is alleviation of dysphagia, n=19) or objective (end point is passage of 12 mm barium pill, n=15) group. Patients in the objective group had less recurrent dysphagia (P=0.02) and required fewer redilatation sessions (P<0.05) than the subjective group.59 The size of the oesophageal lumen will vary depending on the height and weight of the patient, and a 15 mm lumen end point is for someone of average size.

  • Perform weekly or two-weekly dilatation sessions until easy passage of a ≥15 mm dilator is achieved along with symptomatic improvement31 43 59 (GRADE of evidence: moderate; strength of recommendation: strong).

A brief checklist is shown in figure 1. This may be used as a guide.

Figure 1.

Figure 1

Stricture dilatation procedure checklist.

Disease-specific considerations

This section discusses features of specific diseases, which may affect the dilatation procedure and patient outcomes.

Achalasia dilatation

Pneumatic balloon dilatation (PD) is one of a number of effective treatments for achalasia, which include surgical or endoscopic myotomy. However, the latter are outside the remit of this guideline.60 Bougie dilators are not used for achalasia dilatation.

  • Perform dilatation with pneumatic balloons 30–40 mm in diameter starting at 30 mm in the first session to reduce the risk of complications5 19 61 (GRADE of evidence: high; strength of recommendation: strong).

The dilatation technique varies across different studies and there is no consensus in the literature on the optimal method of performing pneumatic dilatation for achalasia. The balloon is usually positioned at the oesophagogastric junction and inflated according to the manufacturers’ instructions for 1–3 min.

  • Perform a second dilatation session 2–28 days later with a larger size balloon of 35 mm5 (GRADE of evidence: high; strength of recommendation: strong).

Most authors advocate a third session either routinely or in cases where symptoms remain (Eckardt score >3) with the cautious use of 40 mm balloon if possible. If the Eckardt score remains >3 after the third session, the treatment is usually considered to have failed.5 Patients with a recurrence of symptoms during follow-up may require further dilatation.5

  • Consider repeat dilatation (after the initial series) during follow-up to maintain symptom response5 (GRADE of evidence: high; strength of recommendation: strong).

The procedure is effective in 90% of patients in the first year and this reduces to 86% in the second year.5 Up to one-third of patients may have recurrence of symptoms during 4–6 years of follow up.62 63 The vast majority can be successfully treated by repeat dilatation, achieving remission rates of up to 97% and 93% at 5 and 10 years, respectively.62

  • Perform dilatation under endoscopic or fluoroscopic control based on clinician’s preference and local expertise64–66 (GRADE of evidence: moderate; strength of recommendation: strong).

Fluoroscopic control is used in the majority of studies reporting safety and efficacy of balloon dilatation in achalasia; however, the safety of endoscopic control alone has been shown in a few studies.64–66 Comparative studies between the latter two approaches are lacking. Routine oesophagograms obtained after PD for achalasia did not reveal any clinically unsuspected perforations and no perforations were missed in cases that were not followed by oesophagograms.67 Impedance planimetry may be a tool that improves decision-making in dilating achalasia.68

  • Consider proton pump inhibitor (PPI) therapy after dilatation as the technique has 10–40% rate of symptomatic gastro-oesophageal reflux disease (GORD) or ulcerative oesophagitis after treatment69–72 (GRADE of evidence: high; strength of recommendation: strong).

PD does not preclude a subsequent myotomy. Similarly, PD may be performed for recurrence of dysphagia following myotomy.73–79

  • Consider performing a water-soluble contrast swallow after dilatation to screen for perforation, but it is not essential67 80 (GRADE of evidence: moderate; strength of recommendation: weak).

PD is contraindicated in patients with poor cardiopulmonary function, frailty or other comorbid illnesses preventing surgery, should an oesophageal perforation occur.81 Patients with hiatal hernia or oesophageal diverticulum have undergone PD safely by experienced operators.82

Peptic strictures

Peptic strictures requiring dilatation have been reported to occur in about 1–2% of patients with reflux oesophagitis, the proportion remaining relatively constant over the past three decades despite a rising incidence of reflux oesophagitis.83 This has been attributed to the widespread adoption of PPI therapy.84 Between 40% and 60% of peptic strictures require only one dilatation,30 83 85 86 with the need for redilatation being highest in the subsequent 1–2 years.86 A recent snapshot of practice in the USA suggests that more than 80% of patients with peptic strictures require only one dilatation.87 This may be because peptic strictures tend to be short and straight, and with the widespread use of PPIs for GORD this more recent survey of practice may reflect the fact that peptic strictures are becoming less severe. Patients with smaller stricture diameter and longer strictures are less likely to respond to dilatation and vice versa.32 58 85

It is clear that dysphagia in patients with reflux oesophagitis may result from oesophagitis rather than stricture, and symptoms may improve with healing of oesophagitis using PPI therapy without the need for dilatation.88 In addition, oesophagitis as well as stricture diameter contribute to the severity of dysphagia,89–91 and healing of oesophagitis in patients with strictures is associated with a reduced need for redilatation.92 Finally, PPI therapy, but not H2 receptor antagonist treatment, reduces the need for, and frequency of, dilatation of peptic strictures after the initial dilatation.92–95

  • Offer PPI therapy to patients with GORD and dysphagia, as this treatment has been shown to reduce the need for oesophageal dilatation83 84 89 92 (GRADE of evidence: high; strength of recommendation: strong).

  • Offer PPI therapy after endoscopic dilatation for peptic strictures in order to reduce recurrence rate89 92–94 (GRADE of evidence: high; strength of recommendation: strong).

  • Offer PPI therapy rather than H2 receptor antagonists, which are ineffective in reducing the need for repeat dilatation (stricture recurrence), less effective in healing of oesophagitis and in providing symptom relief from GORD and dysphagia89 92–95 (GRADE of evidence: high; strength of recommendation: strong).

The management of refractory peptic strictures will be discussed in the relevant section.

Schatzki’s ring

Schatzki’s ring is an annular constriction at the gastro-oesophageal mucosal junction, covered on its proximal side by squamous epithelium and distally by gastric mucosa.96 It was first appreciated on barium swallow radiology, provided the oesophagus was adequately distended,97 occurring in 6–14% of barium swallow examinations and often asymptomatic.98 99 The natural history of asymptomatic Schatzki’s ring is unknown so it is not established whether treatment (for instance, with a PPI) is indicated. Schatzki’s ring is less often seen at endoscopy100 unless the gastro-oesophageal junction is adequately distended by air insufflation. It is a common cause of intermittent dysphagia for solids and of food bolus obstruction: ‘Schatzki’s rule’ states that dysphagia is usual with ring diameters of ≤ 13 mm, and rarely occurs if the diameter exceeds 20 mm,101 with a ‘grey’ area in between where symptoms are less consistently observed.

Schatzki’s ring is associated with gastro-oesophageal reflux39 102 103 and with eosinophilic oesophagitis, even in the absence of other endoscopic oesophageal mucosal abnormalities.100 102 This may explain why patients with rings and acid reflux (demonstrated by pH monitoring), and also unselected patients with Schatzki’s rings appear to have fewer recurrences after dilatation when receiving PPI therapy.39 104 Dysphagia due to Schatzki’s ring was relieved by PPI therapy without the need for dilatation in a small retrospective case series.105

Dilatation therapy for symptomatic Schatzki’s ring is directed toward achieving rupture of the ring; therefore, larger calibre dilators may be needed.101 There is robust evidence for the efficacy of a single dilatation to 16–20 mm.106 Electrosurgical incision of the ring has been reported to be at least as effective in relieving dysphagia due to Schatzki’s ring as a single large calibre dilatation in randomised trials.107 Two studies suggest that incision may lead to longer remission of dysphagia than bougienage, proposing this treatment for patients with recurrence after a course of bougienage.108 109 Relapses still occur, but long-term PPI therapy (omeprazole 20 mg/day) significantly reduces the risk of relapse compared with placebo at up to 48 months of follow-up.39 104

Biopsy excision was shown to be effective and safe in a small feasibility study of 10 patients with dysphagia due to a Schatzki’s ring (six of whom had previously undergone bougie or balloon dilatation). Complete endoscopic obliteration of the ring and improvement of dysphagia was achieved (using jumbo biopsy forceps) in all 10 patients during 379 days (range 63–496 days) of follow-up with no serious complications.110

  • Do not offer dilatation for asymptomatic Schatzki’s rings incidentally discovered on diagnostic endoscopy or contrast studies (performed for unrelated indication)97–99 (GRADE of evidence: low; strength of recommendation: strong).

  • Consider exclusion of eosinophilic oesophagitis by distal, mid and proximal oesophageal biopsies in symptomatic Schatzki’s ring100 102 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Offer a single dilatation session using graded dilatation to a relatively large diameter (16–20 mm) to treat dysphagia related to Schatzki’s ring39 106 111 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Offer PPI therapy after dilatation, as this reduces the risk of relapse of Schatzki’s ring39 104 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Consider electrosurgical incision as an effective alternative treatment to oesophageal dilatation for relieving dysphagia related to Schatzki’s ring108 109 112 (GRADE of evidence: high; strength of recommendation: strong).

In studies reporting this technique, the incision was performed using a standard needle-knife papillotome with a 5 mm cutting wire passed through the accessory channel of the endoscope. Three to four longitudinal incisions were performed radially to the junction of the base of the ring and the oesophageal wall.109 Other experts recommend the use of standard endoscopic submucosal dissection (ESD) needle knife, IT knife or argon plasma coagulation.113 This procedure must be performed by a skilled operator who is familiar with the technique and uses it regularly (such as for ESD procedures).

Post-endoscopic therapy strictures

Oesophageal stenosis can occur after Endoscopic Resection or after Endoscopic Mucosal Ablation for oesophageal neoplasia.

Post-endoscopic resection (ER): stricture dilatation

ER procedures performed in the oesophagus include both endoscopic mucosal resection (EMR) and ESD.

It is generally accepted that once mucosal or submucosal resection of the oesophageal wall has encompassed greater than 75% of the circumference then symptomatic stenosis will occur.114–120 Studies quote an OR for stricture formation of 44.2 (95% CI 4.4 to 443.6) once more than 75% of the circumference has been resected119 and frequency of 49.7% when the length of resection was >40 mm.

For the majority of post-ER strictures, dilatation will resolve symptomatic dysphagia, although repeat procedures are often needed. Pouw et al 121 showed that by using either Savary bougienage or balloon dilatation, all (84) patients who developed symptomatic strictures after stepwise radical ER were adequately treated by a median of 3 (IQR 2–6) dilatation sessions, supplemented by placement of a stent (n=2) or incision therapy (n=4). In 28 (33%) patients the stenosis was graded as severe since more than five endoscopic dilatations, stent placement or incision therapy were required.

Endoscopic balloon dilatation has been shown to be an effective and safe first-line intervention in patients with post -ER strictures, with a reported success rate of 90% and a perforation rate of 0.3%122 in patients with symptomatic dysphagia after EMR for early oesophageal cancer. Balloon dilatation has also been used to prevent strictures after ER. In one study, dilatation was performed after ER and repeated once a week until the mucosal defect was completely healed. The remaining 12 cases were not treated and used as historic controls. Prophylactic dilatation decreased the incidence of stricture (59% vs 92%, P=0.04); reduced the severity of stricture; and shortened the duration required for resolving the stricture (29 days vs 78 days, P=0.04) even when stricture developed.

The main complications associated with post-ER stricture dilatation are perforation, bleeding and a low risk of bacteraemia.118 120 The potential risk of perforation associated with dilatation of post-ER strictures is slightly higher (1.1%) that that seen in benign strictures (0.1%–1.02%).12 35 120 Also, strictures resistant to repeated dilatation do occur, and as in peptic strictures, a fully covered self-expanding metal stent (SEMS) may need to be employed, but there are limitations, including chest pain and stent migration.121 Further large-volume studies are needed to clarify the long-term outcome.

  • Inform patients of up to ~50% chance of developing symptomatic stricture requiring endoscopic dilatation after ER either following EMR or ESD in any of the following situations: resection size >75% of the oesophageal circumference; and a longitudinal resection length of >40 mm123 124 (GRADE of evidence: high; strength of recommendation: strong).

  • Offer dilatation for the management of symptomatic post-mucosal resection strictures32 35 122 123 125–127 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Inform patients that perforation rates of dilatation for post-ER strictures in the oesophagus can be up to 1.1%120 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Offer fully covered SEMS in carefully selected patients for the dilatation of refractory strictures after ER121 128 (GRADE of evidence: low; strength of recommendation: weak).

Post-ER: stricture prevention

Endoscopic resection creates an ulcer which can be healed with PPI therapy based on previous studies on reflux oesophagitis and is known to reduce the risk of stricture formation.92 93 There are no comparative studies after endoscopic resection as PPI is a standard accepted treatment.

Endoscopic intralesional injections of steroids are applied based on the concept that inflammation and fibrosis after oesophageal ER are inhibited by the direct administration of steroids to the resection site. Takahashi et al 129 carried out a randomised, controlled, open-label study to examine whether local steroid injection was an effective prophylactic treatment for oesophageal stenosis following extensive ESD. The authors found no difference in the frequency of stricture formation between the groups, but significantly fewer dilatation sessions were required in the steroid group than in the control group (6.1 (95% CI 2.8 to 9.4) vs 12.5 (95% CI 7.1 to 17.9); P=0.04).

Yamaguchi et al 130 found that the stricture rate with oral prednisolone (5.3%, 1/19) was significantly lower than in the control group (31.8%, 7/22) (P<0.0001). The steroids were started at 30 mg/day on the third day after ESD, tapered gradually, and then discontinued 8 weeks later. Furthermore, the frequency of dilatation in the prednisolone group (mean 1.7, range 0–7) was significantly lower than in the control group (mean 15.6, range 0–48) (P<0.0001). Other studies have shown that using a reducing regimen of oral prednisolone in patients after large EMR or ESD reduces the need for repeated dilatation.131 132

Wen et al 133 performed a single-centre randomised controlled trial and showed that the stricture rate and number of additional dilatations during a short-term follow-up period were significantly lower in subjects treated by stent placement for 8 weeks immediately after ESD than in patients who were not treated with stents. Further studies are required to establish the benefits and risks of SEMS in this setting—in particular, problems of postinsertion hyperplastic regenerative changes, which are difficult to distinguish from neoplastic residues.

Polyglycolic acid (PGA) is a synthetic compound that is completely degraded into a non-toxic degradation product, glycolic acid, over a period of 4–6 months in physiological conditions and has been employed in promoting tissue repair. Iizuka et al 134 evaluated 15 patients after ESD in whom PGA sheets were placed, and oesophageal strictures occurred in only 1/13 patients. These very early data show that PGA sheets may prevent oesophageal strictures after large-scale EMR or ESD in the oesophagus. Other tissue engineering techniques, such as transplantation of autologous oral mucosal epithelial cell sheets into ESD sites, are also being evaluated.135

  • Offer PPI therapy after ER or ablation to reduce stricture occurrence92 93 (GRADE of evidence: low; strength of recommendation: strong).

  • Consider steroid injection at the resection site or oral prednisolone therapy in patients at high risk after large EMR or ESD to reduce stricture formation130–132 136–139 (GRADE of evidence: moderate; strength of recommendation: weak).

  • Offer fully covered SEMS in carefully selected patients for the prevention of refractory strictures after ESD of large lesions placing the stent at the same time as the first stricture dilatation133 (GRADE of evidence: moderate; strength of recommendation: weak).

Post-ablative therapy: treatment and prevention

Field ablation is now accepted as an adjunctive treatment to endoscopic resection of oesophageal neoplasia and, in particular, neoplasia related to Barrett’s oesophagus (BO). Most international guidelines now support this approach with much of the data supporting the use of radiofrequency ablation (RFA).140 These treatments result in oesophageal ulceration which can be healed with PPI therapy based on previous studies on reflux oesophagitis, and PPI treatment is known to reduce the risk of stricture formation.92 93 There are no comparative studies after ablation as PPI is a standard accepted treatment.

Historically, photodynamic therapy (PDT) was the first-line ablation in patients with BO neoplasia. Owing to the toxicity and photosensitivity reactions associated with these agents its role is no longer advocated for the treatment of oesophageal neoplasia. One of the significant drawbacks of this technology was the high rate of stricturing in patients treated with PDT, which approached 36%.141 Most oesophageal strictures in the latter study were managed successfully through repeated dilatations, with one patient requiring an oesophagectomy after dilatation-related perforation.

RFA has now been accepted as the ’gold standard' approach in patients with BO neoplasia. Ablation to a depth of 500 µm favours a reduced rate of stricture formation that is not the case with other ablation techniques. In a landmark randomised controlled trial, in which Shaheen et al 142 compared RFA with a sham procedure, high disease eradication rates were seen and the stricture rate in the treatment group after a median of two treatments was 6%. All patients underwent successful endoscopic dilatation (mean of 2.6 sessions). Data from the UK registry of patients undergoing RFA for BO neoplasia reported a similar stricture rate. Haidry et al 143 showed an overall stricture rate requiring therapeutic dilatation of 9% (30 of 335 patients). All these cases were managed endoscopically with a mean of 1.3 dilatations (range 1–6). Patients who underwent EMR before initiating RFA were more likely to develop strictures than those who did not (12% vs 5.9%; P=0.04).

The role of RFA for early squamous cell neoplasia has been controversial with early data supporting its use in well-selected patients,144 but it is associated with a higher stricture rate than with the same intervention in BO neoplasia. van Vilsteren et al 144 showed a stricture rate of 23% and Bergman et al 145 a stricture rate of 14%. Data from the UK registry, where 20 patients with early squamous neoplasia were treated with RFA, showed a stricture rate of 20%.146

  • Inform patients that stricture formation requiring dilatation is significantly higher in the following situations: after photodynamic therapy (PDT) (36%) compared with other forms of ablation141 147 148; where ER has preceded ablation (12% vs 6%)143; with use of higher doses of energy with RFA for Barrett’s oesophagus (BO)149 150; and after RFA for early squamous cell neoplasia (14–23%)144–146 151 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Offer dilatation in patients with clinically significant stricture formation after RFA, with or without previous ER142 143 152 153 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Offer PPI therapy after ablation to reduce stricture occurrence92 93 (GRADE of evidence: low; strength of recommendation: strong).

Eosinophilic oesophagitis (EoE)

EoE is a common immune/antigen-mediated oesophageal disease characterised clinically by symptoms of oesophageal dysfunction and histologically, by eosinophil predominant inflammation.154 First described by Attwood and Straumann in 1993–94,155 156 EoE usually presents with dysphagia and is now the the most common cause of food bolus obstruction in patients under the age of 50 years.157 EoE is the the most common cause of spontaneous perforation of the oesophagus. It is the second most common benign disease of the oesophagus.158 It is often underdiagnosed and yet 50 times more common than achalasia.158

Preliminary medical treatment and diet elimination for EoE

PPI, diet and topical steroids are all used as first-line treatments (in up to 50%).159 Dietary therapy with elimination of causative allergens, or topical corticosteroids may provide a durable long-term solution.160 161 Topical steroids (such as fluticasone) and budesonide are very effective in the short term, but longer-term studies are needed.162

  • Offer dilatation along with other forms of disease modification using diet, topical steroids or other drugs17 163–165 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Start other treatments for EoE before dilatation if possible, and those may be continued afterwards to prevent or delay recurrence of symptoms163 164 166–169 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Offer preliminary topical steroids followed by dilatation as this is more cost-effective than using dilatation alone as first-line treatment164 170 (GRADE of evidence: moderate; strength of recommendation: strong).

Indications for dilatation in EoE

The indications for dilatation in EoE include established tight stricture, narrow calibre oesophagus, food bolus obstruction and failure of symptoms to respond to diet or drugs.8 16 171 Dilatation of the oesophagus is now a standard treatment for EoE, along with other forms of chronic disease modification using diet, topical steroids or other drugs.17 163–165 Other treatments for EoE should be started before dilatation if possible, and continued afterwards to prevent or delay recurrence of symptoms.163 166–170 172 A recent randomised controlled study by Kavitt et al 170 has shown that preliminary topical steroids followed by dilatation is more cost-effective than using dilatation as the first treatment. In some patients, dilatation can be used as the only treatment.17 162 164 170 173–175 However, caution should be exercised with tight strictures of <7 mm calibre.170

  • Offer dilatation as first line treatment in patients with acute symptoms such as food bolus obstruction and daily dysphagia17 164 173–175 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Offer dilatation to patients with established tight stricture, narrow calibre oesophagus and those who do not respond to diet or drugs8 16 163 168 (GRADE of evidence: high; strength of recommendation: strong).

Risks and complications of dilatation in EoE

Dilatation of EoE is no more dangerous than dilatation for other oesophageal diseases (such as peptic stricture or achalasia), and the perforation rates are similar if safe techniques and flexible endoscopy are employed by experienced operators.17 158 162 163 176–178 Mucosal tears and associated minor bleeding are common after dilatation of EoE (8%), and can be managed conservatively.16 171 176 177

The risk of postprocedural chest pain is particularly common after EoE dilatation and may last for up to 48 hours.169 176 179 Patients should be warned about this possibility, and the need to take fluids and analgesia along with their maintenance EoE therapy.

  • Reassure patients that dilatation of EoE is no more dangerous than dilatation for other oesophageal diseases, and the perforation rates are similar16 17 163 174 176–178 (GRADE of evidence: high; strength of recommendation: strong).

  • Inform EoE patients that chest pain after dilatation is common17 169 176 (GRADE of evidence: high; strength of recommendation: strong).

Follow-up treatment after dilatation in EoE

A good clinical outcome is dysphagia resolution and avoidance of food bolus obstruction after dilatation.8 16 177 Most experts recommend gradual slow dilatation with sessions separated by 3–4 weeks and aim for a diameter of 16–18 mm, if possible.180 Repeat dilatation should be offered if symptoms of severe dysphagia recur or if a symptomatic stricture is diagnosed during follow-up.8 16 177 Symptom response after initial dilatations (about three sessions over several weeks) usually lasts for up to 1 year.167 169 Dilatation of the oesophagus in EoE may be repeated if needed.163 167 174 181

Maintenance treatment with either topical steroid or dietary elimination should continue after dilatation of EoE. A repeat endoscopy is recommended at 6–12 weeks.174 177

  • Inform patients that symptom response after dilatation usually lasts up to 1 year167 169 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Repeat dilatation if needed167 171 174 181 (GRADE of evidence: high; strength of recommendation: strong).

Method of dilatation in EoE

There are no credible data comparing balloon with bougie dilatation in EoE, but most observers prefer balloon to reassure the operator that a perforation is not occurring.16 174 179 181 Otherwise the technique remains the same as for other types of stricture.

Use of distensibility measure to guide dilatation in EoE

Endoscopic Functional Luminal Imaging Probe (EndoFLIP, Crospon, Galway, Ireland) is used in some specialist centres to measure compliance and distensibility. EndoFLIP and Balloon pull through techniques may help in judging the optimal calibre to dilate to but require further study.166 182 183 These techniques are innovative, safe and seem effective. More research on their cost-effectiveness is warranted. The availability and cost-effectiveness will be the main considerations before formulating recommendations for their routine use in clinical practice. A recent study has shown that endoscopy has a sensitivity of only 25% in detecting narrowed oesophagus ≤15 mm in diameter among patients with EoE compared with barium radiology.184

  • Consider the use of special techniques such as EndoFLIP and Balloon pull through to judge the optimal calibre and position of dilatation182 183 (GRADE of evidence: low; strength of recommendation: weak).

Postoperative strictures

Frequency and situation

All surgical interventions have the potential for fibrotic stricturing at the anastomotic site as a complication. Oesophagectomy with oesophago-gastrostomy for oesophageal or gastric cardia malignancy can lead to stricturing in 4%185 to 66%.186 These strictures tend to be short and straight, but occasionally can be complicated.187 188 Methods for prevention of stricturing by surgical technique to maximise vascularisation of the anastomosis is a key strategy in the prevention of oesophageal anastomotic strictures.185 186 188–191

Fundoplication for GORD, both partial and total, is also associated with postoperative dysphagia, affecting 5–43% of people.192 193 Mechanisms behind this include a tight wrap, a slipped wrap and paraoesophageal hernia.194 195 Partial wraps are less likely to cause significant postoperative dysphagia than a Nissen.195 196 Intraoperative evaluation of the oesophagus—for example, using the EndoFLIP device, could allow the operator to determine the length of wrap and optimal tightness of the gastro-oesophageal junction during the fundoplication procedure,197 thereby reducing postoperative dysphagia and/or the need for dilatation.

Preliminary medical treatment and investigations

Nutritional supplementation, particularly in patients with cancer, and PPI therapy following bariatric surgery198 are important. Specific investigations, including endoscopy and barium swallow, are helpful.

  • Consider performing upper GI endoscopy, manometry, pH studies and barium swallow first in patients with persistent dysphagia post-fundoplication surgery, in order to assess the integrity of the wrap and understand the cause of dysphagia prior to dilatation or repeat surgery194 195 (GRADE of evidence: low; strength of recommendation: weak).

Methods of dilatation of postoperative strictures

Treatment of postoperative stricture has used both bougienage188 and balloon dilatation, both under direct endoscopic visualisation185 199 or with fluoroscopy,200 and no data exist to show which is optimal.186

Symptoms improve after the first dilatation session in up to 43% of individuals185 and therefore repeat dilatation is the norm. Typically, a median of three sessions is used before satisfactory relief of dysphagia is achieved.189

Treatment success is difficult to define, limiting comparisons between studies but may be obtained in between 62%195 and 100%.189 Delayed gastric emptying appears to be an additional risk factor for stricture formation, and treatment of this by pyloroplasty or pyloromyotomy may help to reduce the frequency of dilatation sessions required to achieve successful treatment of anastomotic stricture.199

In the post-fundoplication setting, dilatation of the lower oesophageal sphincter typically requires 30–40 mm balloons, similar to those used in the management of achalasia.194 Success can be achieved in approximately two-thirds of patients, although non-responders may require revisional surgery.201

  • Consider treatment of concurrent delayed gastric emptying in order to reduce the need for redilatations199 (GRADE of evidence: low; strength of recommendation: weak).

  • Consider the use of balloon dilatation to 30–40 mm (as with achalasia) in patients with post-Nissen dysphagia194 (GRADE of evidence: low; strength of recommendation: weak).

Use of supplementary methods

The use of steroid injection (0.5 mL aliquots of triamcinolone 40 mg/mL to four quadrants) has been evaluated in anastomotic strictures in a randomised double-blind study and found to be safe when injected with a 4 mm-long, 23-gauge needle immediately before bougie dilatation of anastomotic strictures.202 In this study, the steroid arm appeared superior in the length of time required between dilatation sessions (108 days vs 42 days in the saline group), and the total number of dilatation sessions required (two in the steroid group versus three in the saline group). However neither of these outcomes reached significance. Steroid-treated patients with stricture were found to have significantly more complications, specifically oesophageal candidiasis.

Needle knife incision has also been evaluated in refractory strictures and in the primary treatment of anastomotic strictures.203 204 In experienced hands, this technique is as safe as conventional dilatation methods, but evaluation of the success of this treatment strategy is more variable. Primary treatment with incisional therapy appears to confer no significant advantage over bougie dilatation in the mean number of dilatations or overall success rate at reducing symptoms of dysphagia.203 Specific methods used for incisional therapy include either an endoscopic needle knife or an ‘IT’ knife, incising in four quadrants with the aid of a transparent cap, which enhances the safety of the procedure. The procedure is best done by an operator who is familiar with techniques of incision through experience with ESD or endoscopic retrograde cholangiopancreatography. Incisional therapy appears to maintain luminal patency, at 12 months’ follow-up in 61.5% of cases compared with 19.8% in controls who underwent continued endoscopic balloon dilatation,205 and so has a role in the treatment of unresponsive anastomotic stricture.

  • Use steroid injections (0.5 mL aliquots of triamcinolone 40 mg/mL to the four quadrants) to reduce the frequency of repeat dilatations in anastomotic strictures refractory to initial dilatation approaches. Use a 4 mm-long, 23-gauge needle immediately before bougie dilatation while leaving the needle in for at least 1 min to minimise leakage of the drug and ensure delivery of the full dose to the target area113 202 (GRADE of evidence: moderate; strength of recommendation: weak).

  • Consider using needle knife incision for anastomotic strictures as an alternative to dilatation203 205–207 (GRADE of evidence: moderate; strength of recommendation: weak).

Risks and follow-up

After treatment of postoperative strictures, complication rates such as bleeding or rupture have been reported in up to 30% of cases,200 208 but perforation with mediastinal leakage appears to be no more common than in other types of strictures.

There appears to be no evidence to warrant surveillance of patients postoperatively for anastomotic stricture.

Post-radiation strictures

Radiotherapy treatment has revolutionised the management of most solid organ malignancies, but may induce stricturing of the oesophagus. The risk of stricturing can be anticipated before radiotherapy in patients with greater tumour invasion (T-score) and greater circumferential involvement.209–211 Radiotherapy induces tissue ischaemia, fibrosis and subsequent oesophageal stenosis. In contrast to other oesophageal strictures, the fibrosis often affects the tissues surrounding the oesophagus, creating a non-compliant mediastinum. As a consequence, radiation strictures are frequently refractory to dilatation and progressive. The risk is increased with higher radiation doses.212–217 Furthermore, radiotherapy with concurrent chemotherapy increases the likelihood of stricture217 218 and is a cause of completely obstructed oesophagus,.212 219–221 Prior insertion of a gastrostomy should be considered to aid nutrition in already malnourished individuals and this offers an additional conduit through which dilatation attempts of subsequent oesophageal strictures can be made. Where antegrade passage of a guidewire is unsuccessful, a retrograde attempt through the gastrostoma can be made using catheter and guidewire under fluoroscopic control.

The endoscopic CARD approach can be considered in patients with a completely occluded oesophagus. In most circumstances, this requires a general anaesthetic, although conscious sedation has also been used.218 222 A CT scan is also recommended to exclude nearby vessels.223

Visualisation of the proximal aspect of the stricture is undertaken by insertion of an antegrade endoscope. A second endoscope is inserted through the gastrostomy site and the stricture is trans-illuminated in order to identify the now obstructed lumen. Typically, a guidewire is passed from the distal oesophagus proximally under fluoroscopic guidance, puncturing through the stricture and then removed per-orally.209 212 219 222–224 A needle knife,225 straight catheter223 or EUS fine aspiration needle223 225 226 has also been shown to be effective at traversing the stricture by incision. Biplanar fluoroscopy or cone-beam CT may be used to facilitate an axial alignment of the endoscopes and needles and reduce the risk of perforation. Once a guidewire has been passed a bougie or balloon can dilate to 12–15 mm.219–221 223 224 226–229 In some patients, the placement of a temporary (up to 1 month) fully covered SEMS is necessary to maintain the luminal patency with or without a nasogastric tube for feedig.223

No large studies have been undertaken to evaluate the use of the CARD procedure, and it should be regarded as a last resort for use in expert hands only. Evidence from case series suggests it is safe, with no patients requiring emergency surgical intervention.223 The majority of larger series suggest good success (defined as discontinuation of percutaneous endoscopic gastrostomy feeding), although in most instances, repeated dilatation is still required every 2–3 months.212 219 223

  • Consider a combined anterograde and retrograde dilatation (CARD) or rendezvous approach under general anaesthetic as an alternative to surgery in the treatment of the completely obstructed oesophagus, where local expertise is available209 212 218 219 221 222 225–228 (GRADE of evidence: moderate; strength of recommendation: weak).

  • Use fluoroscopic guidance to assist with the rendezvous procedure209 212 218 219 221 222 225–227 (GRADE of evidence: moderate; strength of recommendation: strong).

  • Use a guidewire to navigate through the obstruction when using the CARD approach to re-establish luminal patency209 212 219 222 225 (GRADE of evidence: low; strength of recommendation: strong).

  • After gaining luminal patency using the CARD procedure, perform subsequent dilatation using either balloon224 226 229 or bougie212 219–221 228 (GRADE of evidence: moderate; strength of recommendation: strong).

Caustic strictures

Oesophageal injury can be caused by ingestion of caustic substances. Alkalis are the the most common caustic agents ingested in Western countries, while acid ingestion is more common in developing countries, such as India. Caustic oesophageal injury can lead to the lower oesophageal sphincter pressure becoming impaired, which in turn leads to gastro-oesophageal reflux that can worsen stricture formation.230 231

After initial radiological assessment, an upper gastrointestinal tract endoscopy, with gentle air insufflations or preferably with CO2, should be considered after caustic ingestion within the first 12–48 hours to determine prognosis and management, including oesophageal stricture formation and subsequent requirement for dilatation.232 Contraindications to endoscopy include radiological suspicion of perforation or burns to the supraglottic and epiglottic areas. A CT grading system for caustic lesions has been proposed, but there is insufficient evidence to demonstrate its widespread utility.233 234

  • Perform upper gastrointestinal tract endoscopy within the first 12–48 hours after caustic ingestion235–238 (GRADE of evidence: moderate; strength of recommendation: strong).

Several techniques have been used in an attempt to prevent stricture formation. These techniques include oral steroids,239 240 antibiotics, mitomycin C and intraluminal stents,241 but there is limited evidence on outcomes.

Late management makes dilatation more complex owing to fibrosis in the oesophageal wall. Dilatation can be carried out with either bougie or balloon dilators. There is no clear advantage of one technique over another.126 242–246 The Savary-Gilliard type was used in the majority of studies reporting on efficacy of bougie dilatation and is preferred by some practitioners in consolidated and fibrotic strictures.

  • Ensure timely management of oesophageal strictures with dilatation as this plays a key role in affecting patient outcomes242–246 (GRADE of evidence: moderate; strength of recommendation: strong).

Dilatation is more hazardous between 1 and 3 weeks after injury and some avoid this time interval. From approximately week 3, scar retraction begins, resulting in stricture formation. The time interval between dilatations varies in published reports but should be less than 2–3 weeks. The number of sessions required to achieve the desired outcome varies; usually three or four are required but the number can be significantly higher.

The perforation rate for caustic strictures is higher than the standard benign oesophageal stricture dilatation rate with anything from 0.4% up to 32% recorded in the literature. The complication rate is lower when performed by those with more experience, and reported to be 4.5%.

  • Consider avoiding dilatation within 3 weeks of initial caustic ingestion242 246 (GRADE of evidence: low; strength of recommendation: weak).

  • Consider a time interval between dilatations of <2 weeks246 247 (GRADE of evidence: very low; strength of recommendation: weak).

Refractory strictures are more common in caustic ingestion. Management has been reported with intralesional steroid injection or topical mitomycin C at the time of dilatation, temporary stent placement, biodegradable stents and a suspended oesophageal silicone prosthesis. If oesophageal dilatation fails then surgical resection can be considered. There is no consensus for the optimum management of these strictures.245 248–252

Refractory strictures

A stricture should be considered refractory after an inability to maintain a luminal diameter of ≥14 mm after five sequential dilatation sessions 1–2 weeks apart or maintain the target diameter for 4 weeks once it has been reached.253 Refractory strictures are rare and challenging. Before embarking on any particular management the clinician and patient should be aware of the poor level of data for the outcomes and risks of most techniques.

  • Inform patients about the lack of good quality evidence for best approach to treatment of refractory strictures (GRADE of evidence: low; strength of recommendation: strong).

  • Consider discussion with, and/or referral to, centres with expertise in treatment and follow-up of patients with refractory strictures (GRADE of evidence: low; strength of recommendation: weak).

  • Ensure optimal management of ongoing inflammation with high dose PPI therapy before defining a stricture as refractory83 84 89 92 (GRADE of evidence: high; strength of recommendation: strong).

  • Consider alternative neuromuscular causes in patients with ongoing dysphagia despite a seemingly adequate oesophageal diameter126 (GRADE of evidence: low; strength of recommendation: strong).

Complex strictures (>2 cm, angulated, irregular, severely narrowed) of the following aetiologies are most often implicated in refractory strictures: anastomotic, radiation induced, caustic, post-ablative therapy.33

Method of dilatation

No trials have compared types of dilators for refractory strictures.

  • Use fluoroscopic guidance during dilatation of refractory oesophageal strictures126 (GRADE of evidence: very low; strength of recommendation: weak).

  • Use either bougie or balloon dilators with the decision individualised on a case by case basis dependent on the nature (length, location, cause) of the stricture126 (GRADE of evidence: low; strength of recommendation: weak).

Intralesional steroid therapy

Intralesional steroid therapy involves the injection of 0.5 mL aliquots of 40 mg/mL triamcinolone to all four quadrants of the stricture. Experts advocate predilatation, although there are no studies directly comparing this with postdilatation injection. Two randomised controlled trials in patients with refractory strictures of mixed, but mostly peptic, aetiology, have demonstrated benefit, with reduction in the number of repeat dilatations and an increase in the dysphagia-free period.254 255 Results have been disappointing for refractory strictures of other aetiologies, with randomised controlled trials failing to show improvement in anastomotic202 and caustic256 aetiologies. In addition, an increase in complications was seen in the steroid-treated patients.202

  • Use intralesional steroid therapy combined with dilatation in refractory strictures with evidence of inflammation (macro- or microscopically) on the assumption that anti-reflux therapy has been maximised previously with no benefit202 254–256 (GRADE of evidence: high; strength of recommendation: strong).

Incisional therapy

Use of a needle or IT knife to perform radial incisions of refractory strictures parallel to the longitudinal axis of the oesophagus has been evaluated. The procedure is performed under direct visualisation with or without a transparent cap. For circumferential strictures, incisions in the four quadrants may be most effective. The outcomes are best for short strictures (<1.5 cm).257 Longer strictures may initially respond, but most will require re-treatment.258

  • Consider incisional therapy in patients with refractory Schatzki’s rings and anastomotic strictures at centres experienced in the use of such techniques257 258 (GRADE of evidence: very low; strength of recommendation: weak).

Stents

The benefit of self-expanding removable stents has been demonstrated in a recent systematic review and meta-analysis, with complete relief of dysphagia in approximately 40% (median follow-up 0–1281 days over the 18 included studies).259 The majority of refractory strictures will respond to placement of between 4 and 8 weeks, although longer periods of up to 3 months may be required.259 It is recommended that stents should not be left in longer than this owing to the risk of embedding. Recurrence rates of refractory strictures remain as high as 69% after stent removal, particularly in patients with long strictures (>7 cm),260 illustrating the difficulties in achieving a satisfactory long-term outcome.

In trials directly comparing metal and plastic stents, outcomes were more favourable with metal stents, with lower migration rates and need for re-intervention.261 262 Stent migration is a considerable problem with both stent types, occurring in approximately 30% of cases.259 Stent placement is associated with adverse events (chest pain, bleeding, perforation, aspiration pneumonia) in 20% and thus patients should give consent accordingly.259 Use of partially or uncovered metal stents must be avoided owing to risk of embedding of the stent in the oesophageal wall, which may preclude safe removal.

  • Offer temporary placement of fully covered self-expanding removable stents in patients where previous methods have been unsuccessful in maintaining adequate oesophageal patency259–265 (GRADE of evidence: low; strength of recommendation: weak).

  • The optimum duration of stent placement is usually between 4 and 8 weeks, but may vary depending on stricture aetiology and length, and type of stent264 (GRADE of evidence: very low; strength of recommendation: weak).

Single biodegradable stent placement appears to be only temporarily effective in the majority of patients with refractory benign oesophageal stricture.266 267 It can, however, reduce the frequency of serial dilatation in selected patients. In the largest study to date, sequential placement of a first, second and then third biodegradable stent resulted in a median dysphagia free period of 90, 55 and 106 days, respectively.267 No patients were dysphagia free at the end of the study, suggesting that this strategy is not effective for long-term dysphagia relief.

  • Consider biodegradable stent placement to reduce the frequency of dilatation in selected cases266 267 (GRADE of evidence: low; strength of recommendation: weak).

Options for failed stricture resolution

Self-dilatation is safe and effective for short, proximal strictures.268–270 For appropriate, well-trained patients willing to undertake this, it appears to be well tolerated, can prevent surgery and the burden of repeated hospital visits.268–270

  • Consider teaching selected, self-motivated patients, with short proximal strictures to self-bougienage268–270 (GRADE of evidence: very low; strength of recommendation: weak).

  • Offer surgery to patients who do not respond or are intolerant to other measures271 272 (GRADE of evidence: low; strength of recommendation: weak).

A brief summary of disease-specific considerations is provided in box 1.

Box 1. Considerations in specific disease areas.

Achalasia:

  • Use pneumatic balloons 30–40 mm in diameter

  • Start at 30 mm in the first session to reduce the risk of complications

  • Perform a second dilatation 2–28 days later with a larger balloon (usually 35 mm)

  • Consider PPI therapy after dilatation

Peptic strictures:

  • PPI therapy long term

  • No role for H2 receptor antagonists

Schatzki’s ring:

  • Asymptomatic=no dilatation

  • Symptomatic=single session (aim for 16–20 mm diameter)

  • Exclude eosinophilic oesophagitis

  • Consider PPI

  • Consider needle knife incision if dilatation not effective

Post-endotherapy:

  • Perforation risk may be higher (around 1.1%)

  • Consider steroid injection to reduce risk of stricture formation

  • Offer PPI to reduce risk of recurrence

Eosinophilic oesophagitis:

  • Consider additional treatments (PPI, steroids, elimination diet)

  • Aim for histological remission

  • Consider dilatation in narrow calibre oesophagus or failure of medical treatment in the absence of a visible stricture

  • Inform patients that chest pain is common

Postoperative:

  • Post-fundoplication:

    • Assess wrap integrity with upper endoscopy, barium swallow, manometry and pH impedance

    • Use pneumatic balloon 30–40 mm as for achalasia

  • Anastomotic:

    • Consider concomitant steroid injection in four quadrants

    • Consider needle knife incision as an alternative to dilatation

Post-radiation:

  • Consider CARD in completely obstructed oesophagus

Caustic:

  • Careful evaluation as usually complex

  • Dilatation not advised in first 3 weeks after ingestion

Refractory:

  • Ensure optimal dose PPI and control of inflammation

  • Consider:

    • Discussion with expert centres

    • Alternative causes/underlying pathology

    • Concomitant steroid injection four quadrants

    • Needle knife incision

    • Fully covered SEMS as temporary measure 4–8 weeks

  • Offer patient the option of self-dilatation

CARD, combined anterograde retrograde dilatation; PPI, proton pump inhibitor; SEMS, self-expanding metal stent.

Economic implications

Oesophageal stricturing has a significant impact on quality of life owing to both dysphagia symptoms and the need for repeated dilatation. Quality of life scores are often further affected by underlying diagnosis, such as head and neck cancer.273 274

No studies have investigated the cost-effectiveness of dilatation, but it is generally appreciated that bougienage has better economic benefits than balloon dilatation. This is owing to the absence of symptomatic or endoscopic difference between the two modalities in addition to the non-significant difference in the need for repeated treatments. Hence the consumable costs of disposing of and replacing TTS balloons outweigh those of reusable Savary bougies. Furthermore, extrapolation from studies in the lower GI tract comparing balloon versus bougienage in the management of postoperative anastomotic strictures has shown similar findings (median cost €680 vs €22.30; P<0.001).275 These considerations obviously require to be balanced with expertise, local availability and endoscopist preference, for example, to allow direct visualisation during the dilatation procedure.

Use of oesophageal stenting is outside the remit of these guidelines, but it may also be considered in cases where repeated dilatation is required and can be considered to add cost-effectiveness when two or more dilatations are avoided.276

There are no other special economic effects of these guidelines, as they are a formalisation of current practice with the evidence base, and we do not advocate any changes or new directions in care that have a major economic impact.

Audit of effectiveness

Items that could be subject to audit to establish good clinical standards of oesophageal dilatation include:

  • Completeness of consent forms with clear documentation in each section (including procedure risks and benefits).

  • Success rate, comfort scores, re-intervention rate (number of dilatations per patient), complication rates, 30-day readmission rates and 30-day mortality rates.27

  • Using a standard scoring system for dysphagia (such as Ogilvie, Dakkak and Bennett, etc) in >90% of patients to provide an objective measure of the efficacy of the therapeutic intervention.27

  • Timeliness of follow-up serial sessions for endoscopic dilatation (within 2 weeks).33 59

  • Perforation rates. The overall perforation rate following dilatation should be <1% for benign strictures27 and 1–2% for achalasia.19 20

Areas for future research

  • Identification of the learning curve, assessment parameters required and direct observation of procedure or skills design for formative and summative assessments for trainees undertaking dilatation.

  • The number of dilatation procedures performed each year required to achieve competency and maintain skill.

  • Direct cost-effectiveness comparison between balloon and bougie dilators.

  • Assessment of the optimal interval between repeat dilatations for tight, complex or refractory strictures.

  • Available data on the role of acid suppression, proton pump inhibition, elimination diet and steroids in EoE are limited by variation in clinical practice and reported outcomes. Randomised controlled trials are needed to identify the optimum treatment to prevent oesophageal strictures in EoE.

  • Clarification of the role of steroids and other methods in reducing the incidence and severity of post-ER strictures. There is an ongoing phase III clinical trial comparing oral steroid versus local steroid injection therapy for the prevention of oesophageal stricture after ESD.277

  • Research into the true incidence of refractory strictures with details of aetiology and comparative outcomes after different treatments.

Acknowledgments

We thank Mimi McCord (patient representative, chair of Heartburn Cancer UK) and Mark Brockhurst (patient representative) for providing advice, guidance and feedback on the planning, recommendations and discussion phases of the guideline.

Footnotes

Contributors: All authors contributed equally to the development of this guideline.

Funding: This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

Competing interests: PDS received research support from Boston Scientific and Cook Medical. YA received research support from Medtronic and is a member of the Clinical Services and Standards Committee of the British Society of Gastroenterology and the UK and Ireland RFA user group. SEA received consultancy fees from Dr Falk Pharma.

Provenance and peer review: Not commissioned; externally peer reviewed.

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