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. 2010 Mar 23;24(2):100–105. doi: 10.1002/jcla.20368

Physical inactivity and cardiovascular risk: baseline observations from men and premenopausal women

Mahdi Garelnabi 1, Emir Veledar 2, Jerome Abramson 3, Jill White‐Welkley 4, Nalini Santanam 5, William Weintraub 6, Sampath Parthasarathy 7,✉
PMCID: PMC6647668  PMID: 20333763

Abstract

Introduction: Physical activity or exercise is a proven deterrent of cardiovascular (CV) diseases. Purpose: In this study, we examined the relationships between baseline values of parameters related to physical activity and known markers of CV disease, including markers of oxidative stress. Methods: A total of 455 healthy men and women between the ages of 18 and 50 were recruited to participate in the study. Levels of lipids/lipoproteins and markers of oxidative stress and inflammation were measured along with the VO2 and duration time spent on treadmill. Results: Women, in general, had a significantly (P<0.0001) higher plasma high density lipoprotein (1.51±0.30 mmol/l), decreased (P<0.0001) low density lipoprotein (LDL) (2.75±0.66 mmol/l), and decreased (P<0.0001) triglycerides levels (2.09±0.85 mmol/l), compared with males (1.21±0.23 mmol/l, 2.92±0.81 mmol/l, and 3.02±1.34 mmol/l, respectively). There was a direct correlation between the levels of plasma LDL and the levels oxidized LDL levels (P<0.0001) in both men and women. Despite a better antiatherogenic lipid profile, the levels of C‐reactive protein in women were significantly (P<0.0001) elevated (3.78±3.66 ng/ml) as compared with those in men (1.82±2.37 ng/ml). Conclusion: These results suggest intrinsic sex differences between men and women in relation to atherogenic risk. J. Clin. Lab. Anal. 24:100–105, 2010. © 2010 Wiley‐Liss, Inc.

Keywords: exercise, oxidative stress, sex, inflammatory markers, atherosclerosis

REFERENCES

  • 1. Adamopoulos S, Parissis J, Kroupis C, et al. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J 2001;22:791–797. [DOI] [PubMed] [Google Scholar]
  • 2. Aguilo A, Tauler P, Pilar G, et al. Pons, antoni effect of exercise intensity and training on antioxidants and cholesterol profile in cyclists. J Nutr Biochem 2003;14:319–325 and 22:791–797. [DOI] [PubMed] [Google Scholar]
  • 3. Mora S, Lee IM, Buring JE, Ridker PM. Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. J Am Med Assoc 2006;295:1412–1419. [DOI] [PubMed] [Google Scholar]
  • 4. Barengo NC, Kastarinen M, Lakka T, Nissinen A, Tuomilehto J. Different forms of physical activity and cardiovascular risk factors among 24–64‐year‐old men and women in Finland. Eur J Cardiov Prev R 2006;13:51–59. [DOI] [PubMed] [Google Scholar]
  • 5. Kelley GA, Kelley KS, Vu Tran Z. Aerobic exercise, lipids and lipoproteins in overweight and obese adults: a meta‐analysis of randomized controlled trials. Int J Obes 2005;29:881–893. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 6. Linna MS, Borg P, Kukkonen‐Harjula K, et al. Successful weight maintenance preserves lower levels of oxidized LDL achieved by weight reduction in obese men. Int J Obes 2007;31:245–253. [DOI] [PubMed] [Google Scholar]
  • 7. Pedersen BK, Saltin B. Evidence for prescribing exercise as therapy in chronic disease. Scand J Med Sci Spor 2006;16:3–63. [DOI] [PubMed] [Google Scholar]
  • 8. Ainslie PN, Reilly T, Maclaren DPM, Campbell IT. Changes in plasma lipids and lipoproteins following 10‐days of prolonged walking: influence of age and relationship to physical activity level. Ergonomics 2005;48:1352–1364. [DOI] [PubMed] [Google Scholar]
  • 9. Coccheri S. Approaches to prevention of cardiovascular complications and events in diabetes mellitu. Drugs 2007;67:997–1026. [DOI] [PubMed] [Google Scholar]
  • 10. Duscha B, Slentz CA, Johnson JL, et al. Effects of exercise training amount and intensity on peak oxygen consumption in middle‐age men and women at risk for cardiovascular disease. Chest 2005;128:2788–2793. [DOI] [PubMed] [Google Scholar]
  • 11. Gill JMR, Al‐Mamari A, Ferrell WR, et al. Effects of a moderate exercise session on postprandial lipoproteins, apolipoproteins and lipoprotein remnants in middle‐aged men. Atherosclerosis 2006;185:87–96. [DOI] [PubMed] [Google Scholar]
  • 12. Halverstadt A, Phares DAW, Kenneth RG, Andrew PH, James M. Endurance exercise training raises high‐density lipoprotein cholesterol and lowers small low‐density lipoprotein and very low‐density lipoprotein independent of body fat phenotypes in older men and women. Metabolism 2007;56:444–450. [DOI] [PubMed] [Google Scholar]
  • 13. Rice T, Despres J‐P, Perusse L, et al. Familial aggregation of blood lipid response to exercise training in the health, risk factors, exercise training, and genetics (HERITAGE) family study. Circulation 2002;105:1904–1908. [DOI] [PubMed] [Google Scholar]
  • 14. Ferguson MA, Alderson NL, Trost SG, Davis PG, Mosher PE, Durstine JL. Plasma lipid and lipoprotein responses during exercise. Scand J Clin Lab Inv 2003;63:73–79. [DOI] [PubMed] [Google Scholar]
  • 15. Kullo IJ, Khaleghi M, Hensrud DD. Markers of inflammation are inversely associated with VO2 max in asymptomatic men. J Appl Physiol 2007;102:1374–1379. [DOI] [PubMed] [Google Scholar]
  • 16. Petersen AMW, Pedersen BK. The anti‐inflammatory effect of exercise. J Appl Physiol 2005;98:1154–1162. [DOI] [PubMed] [Google Scholar]
  • 17. Ramachandran S, Penumetcha M, Merchant NK, Santanam N, Rong R, Parthasarathy S. Exercise reduces preexisting atherosclerotic lesions in LDL receptor knock out mice. Atherosclerosis 2005;178:33–38. [DOI] [PubMed] [Google Scholar]
  • 18. Parthasarathy S, Santanam N. Mechanisms of oxidation, antioxidants, and atherosclerosis. Curr Opin Lipidol 1994;5:371–375. [DOI] [PubMed] [Google Scholar]
  • 19. Parthasarathy S, Santanam N, Ramachandran S, Meilhac O. Oxidants and antioxidants in atherogenesis: an appraisal. J Lipid Res 1999;40:2143–2157. [PubMed] [Google Scholar]
  • 20. Parthasarathy S, Santanam N, Auge N. Oxidized low‐density lipoprotein, a two‐faced Janus in coronary artery disease? Biochem Pharmcol 1998;56:279–284. [DOI] [PubMed] [Google Scholar]
  • 21. Levonen A‐L, Inkala M, Heikura T, et al. Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo. Arterioscl Throm Vas 2007;27:741–747. [DOI] [PubMed] [Google Scholar]
  • 22. Libby P. Inflammation and cardiovascular disease mechanisms. J Clin Nutr 2006;83:456S–460S. [DOI] [PubMed] [Google Scholar]
  • 23. Agostoni P, Banfi C. Matrix metalloproteinase and heart failure: is it time to move from research to clinical laboratories? Eur Heart J 2007;28:659–660. [DOI] [PubMed] [Google Scholar]
  • 24. Shern‐Brewer R, Santanam N, Wetzstein C, White‐Welkley J, Parthasarathy S. Exercise and cardiovascular disease: a new perspective. Arterioscl Throm Vas 1998;18:1181–1187. [DOI] [PubMed] [Google Scholar]
  • 25. Finaud J, Lac G, Filaire E. Oxidative stress: relationship with exercise and training. Sports Med 2006;36:327–358. [DOI] [PubMed] [Google Scholar]
  • 26. Wetzstein CJ, Shern‐Brewer RA, Santanam NG, Nancy R, White‐Welkley JE, Parthasarathy S. Does acute exercise affect the susceptibility of low density lipoprotein to oxidation? F Ra Bio Med 1998;24:679–682. [DOI] [PubMed] [Google Scholar]
  • 27. Parthasarathy S, Santanam N, Ramachandran S, Meilhac O. Potential role of oxidized lipids and lipoproteins in antioxidant defense. F Ra Res 2000;33:197–215. [DOI] [PubMed] [Google Scholar]
  • 28. Karolkiewicz J, Szczesniak L, Deskur‐Smielecka E, Nowak A, Stemplewski R, Szeklicki R. Oxidative stress and antioxidant defense system in healthy, elderly men: relationship to physical activity. Aging Male 2003;6:100–105. [PubMed] [Google Scholar]
  • 29. Meilhac O, Ramachandran S, Chiang K, Santanam N, Parthasarathy S. Role of arterial wall antioxidant defense in beneficial effects of exercise on atherosclerosis in mice. Arterioscl Throm Vas 2001;21:1681–1688. [DOI] [PubMed] [Google Scholar]
  • 30. Bruce RA. Exercise testing for evaluation of ventricular function. N Engl J Med 1977;296:671–675. [DOI] [PubMed] [Google Scholar]
  • 31. Mendez LE, Horowitz IR, Santanam N, Parthasarathy S. Autoantibodies to lipid peroxide‐modified proteins in patients with gynecologic malignancies. Gynecol Oncol 1999;72:518. [Google Scholar]
  • 32. Andican G, Kolda L, Seven A, Ayan F, Sirmaci N, Burcak G. Biochemical evaluation of oxidative stress during exercise in patients with coronary heart disease. Clin Chem Lab Med 2001;39:234–238. [DOI] [PubMed] [Google Scholar]
  • 33. Ji LL, Leeuwenburgh C, Leichtweis S, et al. Oxidative stress and aging. Role of exercise and its influences on antioxidant systems. Ann N Y Acad Sci 1998;854:102–117. [DOI] [PubMed] [Google Scholar]
  • 34. Jimenez L, Lefevre G, Richard R, et al. Oxidative stress in hemodialyzed patients during exhausting exercise. J Sport Med Phys Fit 2001;41:513–520. [PubMed] [Google Scholar]
  • 35. Moreau KL, Gavin KM, Plum AE, Seals DR. Oxidative stress explains differences in large elastic artery compliance between sedentary and habitually exercising postmenopausal women. Menopause 2006;13:951–958. [DOI] [PubMed] [Google Scholar]
  • 36. Barrett‐Connor E. Sex differences in coronary heart disease. Why are women so superior? The 1995 Ancel Keys Lecture Circulation 1997;95:252–264. [DOI] [PubMed] [Google Scholar]
  • 37. JR McNamara HC, Ordovas JM, Peterson J, Wilson PW, Schaefer EJ. Effect of gender, age, and lipid status on low density lipoprotein subfraction distribution. Results from the Framingham Offspring Study. Arteriosclerosis 1987;7:483–490. [DOI] [PubMed] [Google Scholar]
  • 38. Michelle A, Albert RJG, Paul M. Ridker effect of physical activity on serum C ‐ reactive protein. Am J Cardiol 2004;93:221–225. [DOI] [PubMed] [Google Scholar]
  • 39. Timo A, Lakka H‐ML, Tuomo R, et al. Effect of exercise training on plasma levels of C‐reactive protein in healthy adults: the HERITAGE family study. Eur Heart J 2005;26:2018–2025. [DOI] [PubMed] [Google Scholar]

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