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. 2009 Oct 8;24(3):93–113. doi: 10.3103/S089141680903001X

Not gene therapy, but genetic surgery—the right strategy to attack cancer

E D Sverdlov 1,✉
PMCID: PMC7089455  PMID: 32214647

Abstract

In this review, I will suggest to divide all the approaches united now under common term “gene therapy” into two broad strategies of which the first one uses the methodology of targeted therapy with all its characteristics, but with genes in the role of agents targeted at a certain molecular component(s) presumably crucial for cancer maintenance. In contrast, the techniques of the other strategy are aimed at the destruction of tumors as a whole using the features shared by all cancers, for example relatively fast mitotic cell division or active angiogenesis. While the first strategy is “true” gene therapy, the second one is more like genetic surgery when a surgeon just cuts off a tumor with his scalpel and has no interest in knowing delicate mechanisms of cancer emergence and progression. I will try to substantiate the idea that the last strategy is the only right one, and its simplicity is paradoxically adequate to the super-complexity of tumors that originates from general complexity of cell regulation, strongly disturbed in tumor cells, and especially from the complexity of tumors as evolving cell populations, affecting also their ecological niche formed by neighboring normal cells and tissues. An analysis of the most widely used for such a “surgery” suicide gene/prodrug combinations will be presented in some more details.

Keywords: Gene Therapy, Newcastle Disease Virus, Malignant Pleural Mesothelioma, Bystander Effect, Oncolytic Virus

Footnotes

The article is published in the original.

References

  • 1.Felsher D.W. Apmis. 2008;116:629–637. doi: 10.1111/j.1600-0463.2008.01037.x. [DOI] [PubMed] [Google Scholar]
  • 2.Collins S.A., Guinn B.A., Harrison P.T., et al. Curr. Gene Ther. 2008;8:66–78. doi: 10.2174/156652308784049345. [DOI] [PubMed] [Google Scholar]
  • 3.Loisel-Meyer O.L., Foley R., Medin J.A. Front. Biosci. 2008;13:3202–3214. doi: 10.2741/2921. [DOI] [PubMed] [Google Scholar]
  • 4.Podhajcer M.V., Lopez M., Mazzolini G. Cytokine Growth Factor Rev. 2007;18:183–194. doi: 10.1016/j.cytogfr.2007.01.014. [DOI] [PubMed] [Google Scholar]
  • 5.Merlo L.M., Pepper J.W., Reid B.J., et al. Nat. Rev. Cancer. 2006;6:924–935. doi: 10.1038/nrc2013. [DOI] [PubMed] [Google Scholar]
  • 6.Wood L.D., Parsons D.W., Jones S., et al. Science. 2007;318:1108–1113. doi: 10.1126/science.1145720. [DOI] [PubMed] [Google Scholar]
  • 7.Hanahan D., Weinberg R.A. Cell. 2000;100:57–70. doi: 10.1016/S0092-8674(00)81683-9. [DOI] [PubMed] [Google Scholar]
  • 8.Higa G.M. Expert Rev. Anticancer Ther. 2004;4:61–75. doi: 10.1586/14737140.4.1.61. [DOI] [PubMed] [Google Scholar]
  • 9.Potter J.D. Nat. Rev. Cancer. 2007;7:464–474. doi: 10.1038/nrc2146. [DOI] [PubMed] [Google Scholar]
  • 10.Loeb L.A., Loeb K.R., Anderson J.P. Proc. Natl. Acad. Sci. USA. 2003;100:776–781. doi: 10.1073/pnas.0334858100. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 11.Kitano H. Nat. Rev. Cancer. 2004;4:227–235. doi: 10.1038/nrc1300. [DOI] [PubMed] [Google Scholar]
  • 12.Axelrod R., Axelrod D.E., Pienta K.J. Proc. Natl. Acad. Sci. USA. 2006;103:13474–13479. doi: 10.1073/pnas.0606053103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.Kalluri R., Zeisberg M. Nat. Rev. Cancer. 2006;6:392–401. doi: 10.1038/nrc1877. [DOI] [PubMed] [Google Scholar]
  • 14.Kinzler K.W., Vogelstein B. Science. 1998;280:1036–1037. doi: 10.1126/science.280.5366.1036. [DOI] [PubMed] [Google Scholar]
  • 15.Bhowmick N.A., Neilson E.G., Moses E.G. Nature. 2004;432:332–337. doi: 10.1038/nature03096. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 16.Guarino M. Int. J. Biochem. Cell Biol. 2007;39:2153–2160. doi: 10.1016/j.biocel.2007.07.011. [DOI] [PubMed] [Google Scholar]
  • 17.Polyak K. Nature Cancer Rev. 2009;9:265–276. doi: 10.1038/nrc2620. [DOI] [PubMed] [Google Scholar]
  • 18.Zalatnai, A., Curr. Mol. Med., 2006, pp. 685–693. [DOI] [PubMed]
  • 19.Radisky D.C., Kenny P.A., Bissell M.J. J. Cell Biochem. 2007;101:830–839. doi: 10.1002/jcb.21186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 20.Orimo A., Weinberg R.A. Cell Cycle. 2006;5:1597–1601. doi: 10.4161/cc.5.15.3112. [DOI] [PubMed] [Google Scholar]
  • 21.Edelstein M.L., Abedi M.R., Wixon J. J. Gene Med. 2007;9:833–842. doi: 10.1002/jgm.1100. [DOI] [PubMed] [Google Scholar]
  • 22.Lumniczky K., Safrany G. Pathol. Oncol. Res. 2006;12:118–124. doi: 10.1007/BF02893457. [DOI] [PubMed] [Google Scholar]
  • 23.Seth P. Cancer Biol. Ther. 2005;4:512–517. doi: 10.4161/cbt.4.5.1705. [DOI] [PubMed] [Google Scholar]
  • 24.Wagner E. J. Bion. 2007;12(Suppl.1):S77–S82. [PubMed] [Google Scholar]
  • 25.Cross D., Burmester J.K. Clin. Med. Res. 2006;4:218–227. doi: 10.3121/cmr.4.3.218. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26.Fang B., Roth J.A. Cancer Biol. Ther. 2003;2:S115–S121. [PubMed] [Google Scholar]
  • 27.Räty J.K. Curr. Mol. Pharmacol. 2008;1:13–23. doi: 10.2174/1874467210801010013. [DOI] [PubMed] [Google Scholar]
  • 28.Shiraishi K., Kato S., Han S.Y., et al. J. Biol. Chem. 2004;279:348–355. doi: 10.1074/jbc.M310815200. [DOI] [PubMed] [Google Scholar]
  • 29.Oliver M., Petitjean A., Marcel V., et al. Cancer Gene Ther. 2009;16:1–12. doi: 10.1038/cgt.2008.69. [DOI] [PubMed] [Google Scholar]
  • 30.Luqmani Y.A. Med. Princ. Pract. 2005;14(Suppl.1):35–48. doi: 10.1159/000086183. [DOI] [PubMed] [Google Scholar]
  • 31.Xue W., Zender L., Miething C., et al. Nature. 2007;445:656–660. doi: 10.1038/nature05529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 32.Huang C.L., Yokomise H., Miyatake A. Future Oncol. 2007;3:83–93. doi: 10.2217/14796694.3.1.83. [DOI] [PubMed] [Google Scholar]
  • 33.Matins C.P., Brown-Swigart L., Evan G.I. Cell. 2006;127:1323–1334. doi: 10.1016/j.cell.2006.12.007. [DOI] [PubMed] [Google Scholar]
  • 34.Peng Z. Hum. Gene Ther. 2005;16:1016–1027. doi: 10.1089/hum.2005.16.1016. [DOI] [PubMed] [Google Scholar]
  • 35.Wilson J.M. Hum. Gene Ther. 2005;16:1014–1015. doi: 10.1089/hum.2005.16.1014. [DOI] [PubMed] [Google Scholar]
  • 36.Merritt J.A., Roth J.A., Logothetis C.J. Semin. Oncol. 2001;28:105–114. doi: 10.1016/S0093-7754(01)90288-X. [DOI] [PubMed] [Google Scholar]
  • 37.Authors N. Drugs. 2007;8:176–187. [Google Scholar]
  • 38.Guo J., Xin H. Science. 2006;314:1232–1235. doi: 10.1126/science.314.5803.1232. [DOI] [PubMed] [Google Scholar]
  • 39.Xin H. Science. 2006;314:1233. doi: 10.1126/science.314.5803.1233. [DOI] [PubMed] [Google Scholar]
  • 40.Altieri D.C. Nat. Rev. Cancer. 2008;8:61–70. doi: 10.1038/nrc2293. [DOI] [PubMed] [Google Scholar]
  • 41.Mita A.C., Mita M.M., Nawrocki S.T., et al. Clin. Cancer Res. 2008;14:5000–5005. doi: 10.1158/1078-0432.CCR-08-0746. [DOI] [PubMed] [Google Scholar]
  • 42.Pennati M., Folini M., Zaffarini N. Expert Opin. Ther. Targets. 2008;12:463–476. doi: 10.1517/14728222.12.4.463. [DOI] [PubMed] [Google Scholar]
  • 43.Altieri D.C. Mol. Cancer Ther. 2006;5:478–482. doi: 10.1158/1535-7163.MCT-05-0436. [DOI] [PubMed] [Google Scholar]
  • 44.Zhen H.N., Li L.W., Zhang W., et al. Int. J. Oncol. 2007;31:1111–1117. [PubMed] [Google Scholar]
  • 45.Chen J.S., Liu J.C., Shen L., et al. Cancer Gene Ther. 2004;11:740–747. doi: 10.1038/sj.cgt.7700752. [DOI] [PubMed] [Google Scholar]
  • 46.Wang Y., Zhu Z., Zeng F., et al. Univ. Sci. Technolog. Med. Sci. 2007;27:444–447. doi: 10.1007/s11596-007-0424-3. [DOI] [PubMed] [Google Scholar]
  • 47.Outhit A., Matrougui K., Bengrine A., et al. Front. Biosci. 2007;12:1260–1270. doi: 10.2741/2144. [DOI] [PubMed] [Google Scholar]
  • 48.Schmitt E., Gehrmann M., Brunet M., et al. J. Leukoc. Biol. 2007;81:15–27. doi: 10.1189/jlb.0306167. [DOI] [PubMed] [Google Scholar]
  • 49.Bishop S.C., Burlison J.A., Blagg B.S. Curr. Cancer Drug. Targets. 2007;7:369–388. doi: 10.2174/156800907780809778. [DOI] [PubMed] [Google Scholar]
  • 50.Powers M.V., Workmann P. Endocr. Relat. Cancer. 2006;13Suppl.1:S125–S135. doi: 10.1677/erc.1.01324. [DOI] [PubMed] [Google Scholar]
  • 51.Li, Y., Zhang, T., Schwartz, S.J., et al., Drug Resist. Update, 2009, vol. 1.
  • 52.Aalinkeel R., Bindukumar B., Reynolds J.L., et al. Prostate. 2008;68:1773–1789. doi: 10.1002/pros.20845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 53.Cheng T.L., Teng C.F., Tsai W.H., et al. Cancer Gene Ther. 2009;16:516–531. doi: 10.1038/cgt.2008.102. [DOI] [PubMed] [Google Scholar]
  • 54.McCormick F. Nat. Rev. Cancer. 2001;1:130–141. doi: 10.1038/35101008. [DOI] [PubMed] [Google Scholar]
  • 55.Flotte T.R. J. Cell Physiol. 2007;213:301–305. doi: 10.1002/jcp.21173. [DOI] [PubMed] [Google Scholar]
  • 56.Persano L., Crescenzi M., Indraccolo S. Mol. Aspects Med. 2007;28:87–114. doi: 10.1016/j.mam.2006.12.005. [DOI] [PubMed] [Google Scholar]
  • 57.Bergers G., Hanahan D. Nat. Rev. Cancer. 2008;8:592–603. doi: 10.1038/nrc2442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 58.Liu T.C., Kirn D. Gene Ther. 2008;15:877–884. doi: 10.1038/gt.2008.72. [DOI] [PubMed] [Google Scholar]
  • 59.Parato K.A., Senger D., Forsyth P.A., et al. Nat. Rev. Cancer. 2005;5:965–976. doi: 10.1038/nrc1750. [DOI] [PubMed] [Google Scholar]
  • 60.Vaha-Koskela M.J., Heikkila J.E., Hinkkanen A.E. Cancer Lett. 2007;254:178–216. doi: 10.1016/j.canlet.2007.02.002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 61.Prestwich, R., Errington, F., Harrington, K., et al., Clinical Medicine: Oncology, 2008, comments 2, pp. 83–96. [DOI] [PMC free article] [PubMed]
  • 62.Kirn D.H., Thorne S.H. Nat. Rev. Cancer. 2009;9:64–71. doi: 10.1038/nrc2545. [DOI] [PubMed] [Google Scholar]
  • 63.Randall R.E., Goodbourn S. J. Gen. Virol. 2008;89:1–47. doi: 10.1099/vir.0.83391-0. [DOI] [PubMed] [Google Scholar]
  • 64.de Haro C., Mendez R., Santoyo J. Faseb J. 1996;10:1378–1387. doi: 10.1096/fasebj.10.12.8903508. [DOI] [PubMed] [Google Scholar]
  • 65.Strong J.E., Coffey M.C., Tang D., et al. Embo J. 1998;17:3351–3362. doi: 10.1093/emboj/17.12.3351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 66.Marcato P., Shmulevitz M., Pan D., et al. Mol. Ther. 2007;15:1522–1530. doi: 10.1038/sj.mt.6300179. [DOI] [PubMed] [Google Scholar]
  • 67.Ring C.J. J. Gen. Virol. 2002;83:491–502. doi: 10.1099/0022-1317-83-3-491. [DOI] [PubMed] [Google Scholar]
  • 68.Dmitriev I., Krasnykh V., Miller C.R., et al. J. Virol. 1998;72:9706–9713. doi: 10.1128/jvi.72.12.9706-9713.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 69.Liu Y., Deisseroth A. Cancer Gene Ther. 2006;13:845–855. doi: 10.1038/sj.cgt.7700962. [DOI] [PubMed] [Google Scholar]
  • 70.Zhu Z.B., Chen Y., Makhija S.K., et al. Int. J. Oncol. 2006;29:1319–1329. [PubMed] [Google Scholar]
  • 71.Lei N., Shen F.B., Chang J.H., et al. Cancer Gene Ther. 2009;16:33–43. doi: 10.1038/cgt.2008.46. [DOI] [PubMed] [Google Scholar]
  • 72.Zeh H.J., Bartlett D.L. Cancer Gene Ther. 2002;9:1001–1012. doi: 10.1038/sj.cgt.7700549. [DOI] [PubMed] [Google Scholar]
  • 73.Stojdl D.F., Lichty B.D., tenOever B.R., et al. Cancer Cell. 2003;4:263–275. doi: 10.1016/S1535-6108(03)00241-1. [DOI] [PubMed] [Google Scholar]
  • 74.Li Q.X., Liu G., Wong-Staal F. Int. J. Cancer. 2008;123:493–499. doi: 10.1002/ijc.23692. [DOI] [PubMed] [Google Scholar]
  • 75.Todo T. Front. Biosci. 2008;13:2060–2064. doi: 10.2741/2823. [DOI] [PubMed] [Google Scholar]
  • 76.Nawa A., Luo C., Zhang L., et al. Curr. Gene Ther. 2008;8:208–221. doi: 10.2174/156652308784746422. [DOI] [PubMed] [Google Scholar]
  • 77.Zheng J.N., Pei D.S., Mao L.J., et al. Cancer Gene Ther. 2009;16:20–32. doi: 10.1038/cgt.2008.61. [DOI] [PubMed] [Google Scholar]
  • 78.Zheng J.N., Pei D.S., Sun F.H., et al. Cancer Biol. Ther. 2009;8:1–8. doi: 10.1158/1535-7163.MCT-08-0801. [DOI] [PubMed] [Google Scholar]
  • 79.Liu T.C., Kirn D. Cancer Res. 2007;67:429–432. doi: 10.1158/0008-5472.CAN-06-2871. [DOI] [PubMed] [Google Scholar]
  • 80.Aghi M., Martuza R.L. Oncogene. 2005;24:7802–7816. doi: 10.1038/sj.onc.1209037. [DOI] [PubMed] [Google Scholar]
  • 81.Liu T.C., Galanis E., Kirn D. Nat. Clin. Pract. Oncol. 2007;4:101–117. doi: 10.1038/ncponc0736. [DOI] [PubMed] [Google Scholar]
  • 82.Visvader J.E., Lindeman G.J. Nat. Rev. Cancer. 2008;8:755–768. doi: 10.1038/nrc2499. [DOI] [PubMed] [Google Scholar]
  • 83.Fillat C., Carrio M., Cascante A., et al. Curr. Gene Ther. 2003;3:13–26. doi: 10.2174/1566523033347426. [DOI] [PubMed] [Google Scholar]
  • 84.Altaner C. Cancer Lett. 2008;270:191–201. doi: 10.1016/j.canlet.2008.04.023. [DOI] [PubMed] [Google Scholar]
  • 85.Portsmouth D., Hlavaty J., Renner M. Mol. Aspects Med. 2007;28:4–41. doi: 10.1016/j.mam.2006.12.001. [DOI] [PubMed] [Google Scholar]
  • 86.Saukkonen K., Hemminki A. Expert Opin. Biol. Ther. 2004;4:683–696. doi: 10.1517/14712598.4.5.683. [DOI] [PubMed] [Google Scholar]
  • 87.Trosko J.E., Chang C.C., Upham B.L., et al. Ann. N. Y. Acad. Sci. 2004;1028:192–201. doi: 10.1196/annals.1322.023. [DOI] [PubMed] [Google Scholar]
  • 88.Pardal R., Clarke M.F., Morrison S.J. Nat. Rev. Cancer. 2003;3:895–902. doi: 10.1038/nrc1232. [DOI] [PubMed] [Google Scholar]
  • 89.Tan B.T., Park C.Y., Ailles L.E., et al. Lab. Invest. 2006;8:1203–1207. doi: 10.1038/labinvest.3700488. [DOI] [PubMed] [Google Scholar]
  • 90.Schatton T., Frank M.H. Pigment Cell Melanoma Res. 2008;21:39–55. doi: 10.1111/j.1755-148X.2007.00427.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 91.Woodward W.A., Sulman E.P. Cancer Metastasis Rev. 2008;27:459–470. doi: 10.1007/s10555-008-9130-2. [DOI] [PubMed] [Google Scholar]
  • 92.Lewis M.T. Future Oncol. 2008;4:585–589. doi: 10.2217/14796694.4.5.585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 93.Mesnil M., Yamasaki H. Cancer Res. 2000;60:3989–3999. [PubMed] [Google Scholar]
  • 94.Matono S., Tanaka T., Sueyoshi S., et al. Int. J. Oncol. 2003;23:1309–1315. [PubMed] [Google Scholar]
  • 95.Degreve B., De Clercq E., Balzarini J. Gene Ther. 1999;6:162–170. doi: 10.1038/sj.gt.3300806. [DOI] [PubMed] [Google Scholar]
  • 96.van Dillen I.J., Mulder N.H., Vaalburg W., et al. Curr. Gene Ther. 2002;2W:307–322. doi: 10.2174/1566523023347733. [DOI] [PubMed] [Google Scholar]
  • 97.Syrigos K.N., Katirtzoglou N., Kotteas E., et al. Curr. Pharm. Des. 2008;14:2173–2183. doi: 10.2174/138161208785740162. [DOI] [PubMed] [Google Scholar]
  • 98.Leithe E., Sirnes S., Omori Y., et al. Crit. Rev. Oncog. 2006;12:225–256. doi: 10.1615/critrevoncog.v12.i3-4.30. [DOI] [PubMed] [Google Scholar]
  • 99.Yamasaki H., Omori Y., Krutovskikh V., et al. Novartis Found. Symp. 1999;219:241–254. doi: 10.1002/9780470515587.ch15. [DOI] [PubMed] [Google Scholar]
  • 100.Mesnil M., Crespin S., Avanzo J.L., et al. Biochim. Biophys. Acta. 2005;1719:25–45. doi: 10.1016/j.bbamem.2005.11.004. [DOI] [PubMed] [Google Scholar]
  • 101.Moolten F.L. Cancer Res. 1986;46:5276–5281. [PubMed] [Google Scholar]
  • 102.Vile R.G., Castleden S., Marshall J., et al. Int. J. Cancer. 1997;71:267–274. doi: 10.1002/(SICI)1097-0215(19970410)71:2<267::AID-IJC23>3.0.CO;2-D. [DOI] [PubMed] [Google Scholar]
  • 103.Woo C.Y., Osada T., Clay T.M., et al. Expert Opin. Biol. Ther. 2006;6:1123–1134. doi: 10.1517/14712598.6.11.1123. [DOI] [PubMed] [Google Scholar]
  • 104.Shirakawa T. Mol. Cells. 2008;25:462–466. [PubMed] [Google Scholar]
  • 105.Immonen A., Vapalahti M., Tyynela K., et al. Mol. Ther. 2004;10:967–972. doi: 10.1016/j.ymthe.2004.08.002. [DOI] [PubMed] [Google Scholar]
  • 106.Greco O., Dachs G.U. J. Cell Physiol. 2001;187:22–36. doi: 10.1002/1097-4652(2001)9999:9999<::AID-JCP1060>3.0.CO;2-H. [DOI] [PubMed] [Google Scholar]
  • 107.Rangarajan A., Weinberg R.A. Nat. Rev. Cancer. 2003;3:952–959. doi: 10.1038/nrc1235. [DOI] [PubMed] [Google Scholar]
  • 108.Cronier L., Crespin S., Strale P.O., et al. Antioxid. Redox Signal. 2009;11:323–338. doi: 10.1089/ars.2008.2153. [DOI] [PubMed] [Google Scholar]
  • 109.Fick J., Barker F.G., Dazin P., et al. Proc. Natl. Acad. Sci. USA. 1995;92:11071–11075. doi: 10.1073/pnas.92.24.11071. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 110.Nicholas T.W., Read S.B., Burrows F.J., et al. Histol. Histopathol. 2003;18:495–507. doi: 10.14670/HH-18.495. [DOI] [PubMed] [Google Scholar]
  • 111.Tanaka T., Yamasaki H., Mesnil M. Mol. Carcinog. 2001;30:176–180. doi: 10.1002/mc.1026. [DOI] [PubMed] [Google Scholar]
  • 112.Park J.Y., Elshami A.A., Amin K., et al. Gene Ther. 1997;4:909–917. doi: 10.1038/sj.gt.3300477. [DOI] [PubMed] [Google Scholar]
  • 113.Gagandeep S., Brew R., Green B., et al. Cancer Gene Ther. 1996;3:83–88. [PubMed] [Google Scholar]
  • 114.Stefani A.L., Barzon L., Castagliuolo I., et al. J. Hepatol. 2005;42:728–735. doi: 10.1016/j.jhep.2004.12.037. [DOI] [PubMed] [Google Scholar]
  • 115.Goto T., Nishi T., Kobayashi O., et al. Mol. Ther. 2004;10:929–937. doi: 10.1016/j.ymthe.2004.07.028. [DOI] [PubMed] [Google Scholar]
  • 116.Lee K.H., Piao H., Son B.R., et al. Cancer Gene Ther. 2004;11:570–576. doi: 10.1038/sj.cgt.7700736. [DOI] [PubMed] [Google Scholar]
  • 117.Zhang J.H., Wan M.X., Pan B.R., et al. Cancer Lett. 2006;235:191–201. doi: 10.1016/j.canlet.2004.10.054. [DOI] [PubMed] [Google Scholar]
  • 118.Beltinger C., Fulda S., Walczak H. Cancer Gene Ther. 2002;9:372–381. doi: 10.1038/sj.cgt.7700448. [DOI] [PubMed] [Google Scholar]
  • 119.Liu C.S., Kong B., Xia H.H., et al. J. Gene Med. 2001;3:145–152. doi: 10.1002/jgm.164. [DOI] [PubMed] [Google Scholar]
  • 120.Beerens A.M., Rots M.G., de Vries E.F., et al. Int. J. Mol. Med. 2007;19:841–849. doi: 10.3892/ijmm.19.5.841. [DOI] [PubMed] [Google Scholar]
  • 121.Luo C., Nawa A., Yamauchi Y., et al. Virus Genes. 2007;34:263–272. doi: 10.1007/s11262-006-0013-8. [DOI] [PubMed] [Google Scholar]
  • 122.Koshizuka T., Takakuwa H., Goshima F., et al. Biochem. Biophys. Res. Commun. 2001;288:597–602. doi: 10.1006/bbrc.2001.5790. [DOI] [PubMed] [Google Scholar]
  • 123.Tasciotti E., Giacca M. Hum. Gene Ther. 2005;16:1389–1403. doi: 10.1089/hum.2005.16.1389. [DOI] [PubMed] [Google Scholar]
  • 124.Cao L., Si J., Wang W., et al. Mol Cells. 2006;21:104–111. [PubMed] [Google Scholar]
  • 125.Rautsi O., Lehmusvaara S., Ketola A., et al. Cancer Gene Ther. 2008;15:303–314. doi: 10.1038/cgt.2008.17. [DOI] [PubMed] [Google Scholar]
  • 126.Black M.E., Kokoris M.S., Sabo P. Cancer Res. 2001;61:3022–3026. [PubMed] [Google Scholar]
  • 127.Kokoris M.S., Black M.E. Protein Sci. 2002;11:2267–2272. doi: 10.1110/ps.2460102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 128.Likar Y., Dobrenkov K., Olszewska M., et al. J. Nucl. Med. 2008;49:713–720. doi: 10.2967/jnumed.107.046425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 129.Willmon C.L., Krabbenhoft E., Black M.E. Gene Ther. 2006;13:1309–1312. doi: 10.1038/sj.gt.3302794. [DOI] [PubMed] [Google Scholar]
  • 130.Kajiwara E., Kawano K., Hattori Y., et al. J. Control Release. 2007;120:104–110. doi: 10.1016/j.jconrel.2007.04.011. [DOI] [PubMed] [Google Scholar]
  • 131.Hayashi K., Lee J.B., Maitani Y., et al. J. Gene Med. 2006;8:1956–1967. doi: 10.1002/jgm.931. [DOI] [PubMed] [Google Scholar]
  • 132.Li P.X., Ngo D., Brade A.M., et al. Cancer Gene Ther. 1999;6:179–190. doi: 10.1038/sj.cgt.7700005. [DOI] [PubMed] [Google Scholar]
  • 133.Frank O., Rudophp C., Heberlein C., et al. Blood. 2004;104:3543–3549. doi: 10.1182/blood-2004-03-0852. [DOI] [PubMed] [Google Scholar]
  • 134.Yang L., Hwang R., Chiang Y., et al. Clin. Cancer Res. 1998;4:731–741. [PubMed] [Google Scholar]
  • 135.Kurdow R., Schniewind B., Boehle A.S., et al. Anticancer Res. 2004;24:827–831. [PubMed] [Google Scholar]
  • 136.Beck C., Cayeux S., Lupton S.D., et al. Hum. Gene Ther. 1995;6:1525–1530. doi: 10.1089/hum.1995.6.12-1525. [DOI] [PubMed] [Google Scholar]
  • 137.Tomicic M.T., Thust R., Sobol R.W., et al. Cancer Res. 2001;61:7399–7403. [PubMed] [Google Scholar]
  • 138.Srivastava D.K., Husain I., Arteaga C.L., et al. Carcinogenesis. 1999;20:1949–1954. doi: 10.1093/carcin/20.6.1049. [DOI] [PubMed] [Google Scholar]
  • 139.Deeley R.G., Westlake C., Cole S.P. Physiol. Rev. 2006;86:849–899. doi: 10.1152/physrev.00035.2005. [DOI] [PubMed] [Google Scholar]
  • 140.Adachi M., Sampath J., Lan L.B., et al. J. Biol. Chem. 2002;277:38998–39004. doi: 10.1074/jbc.M203262200. [DOI] [PubMed] [Google Scholar]
  • 141.Park S.Y., Lee W., Lee J., et al. Cancer Lett. 2008;261:205–214. doi: 10.1016/j.canlet.2007.11.011. [DOI] [PubMed] [Google Scholar]
  • 142.Fischer U., Steffens S., Frank S., et al. Oncogene. 2005;24:1231–1243. doi: 10.1038/sj.onc.1208290. [DOI] [PubMed] [Google Scholar]
  • 143.Ahn M., Lee S.J., Li X., et al. Cancer Gene Ther. 2009;16:73–82. doi: 10.1038/cgt.2008.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 144.Yi Y., Hahm S.H., Lee K.H. Curr. Gene Ther. 2005;5:25–35. doi: 10.2174/1566523052997514. [DOI] [PubMed] [Google Scholar]
  • 145.Lavillette D., Russell S.J., Cosset F.L. Curr. Opin. Biotechnol. 2001;12:461–466. doi: 10.1016/S0958-1669(00)00246-9. [DOI] [PubMed] [Google Scholar]
  • 146.Moon C., Oh Y., Roth J.A. Clin. Cancer Res. 2003;9:5055–5067. [PubMed] [Google Scholar]
  • 147.Rocconi R.P., Numnum T.M., Stoff-Khalili M., et al. Curr. Gene Ther. 2005;5:643–653. doi: 10.2174/156652305774964668. [DOI] [PubMed] [Google Scholar]
  • 148.Relph K.L., Pandha H. Semin. Oncol. 2005;32:573–582. doi: 10.1053/j.seminoncol.2005.09.001. [DOI] [PubMed] [Google Scholar]
  • 149.Gunther M., Wagner E., Ogris M. Curr. Med. Chem. Anticancer Agents. 2005;5:157–171. doi: 10.2174/1568011053174855. [DOI] [PubMed] [Google Scholar]
  • 150.Dong J.Y., Woraratanadharm J. Future Oncol. 2005;1:361–373. doi: 10.1517/14796694.1.3.361. [DOI] [PubMed] [Google Scholar]
  • 151.Burrows F.J., Thorpe P.E. Pharmacol. Ther. 1994;64:155–174. doi: 10.1016/0163-7258(94)90037-X. [DOI] [PubMed] [Google Scholar]
  • 152.Thorpe P.E., Burrows F.J. Breast Cancer Res. Treat. 1995;36:237–251. doi: 10.1007/BF00666044. [DOI] [PubMed] [Google Scholar]
  • 153.Dvorak H.F. N. Engl. J. Med. 1986;315:1650–1659. doi: 10.1056/NEJM198612253152606. [DOI] [PubMed] [Google Scholar]
  • 154.Langley R.R., Fidler I.J. Endocr. Rev. 2007;28:297–321. doi: 10.1210/er.2006-0027. [DOI] [PubMed] [Google Scholar]
  • 155.Varga-Szabo D., Pleines I., Nieswandt I. Arterioscler. Thromb. Vasc. Biol. 2008;28:403–412. doi: 10.1161/ATVBAHA.107.150474. [DOI] [PubMed] [Google Scholar]
  • 156.Schmugge M., Rand M.L., Freedman J. Transfus. Apher. Sci. 2003;28:269–277. doi: 10.1016/S1473-0502(03)00046-6. [DOI] [PubMed] [Google Scholar]
  • 157.Sugimoto M. Int. J. Hematol. 2002;75:19–24. doi: 10.1007/BF02981974. [DOI] [PubMed] [Google Scholar]
  • 158.Hall F.L., Gordon E.M., Wu L., et al. Hum. Gene Ther. 1997;8:2183–2192. doi: 10.1089/hum.1997.8.18-2183. [DOI] [PubMed] [Google Scholar]
  • 159.Hall F.L., Liu L., Zhu N.L., et al. Hum. Gene Ther. 2000;11:983–993. doi: 10.1089/10430340050015293. [DOI] [PubMed] [Google Scholar]
  • 160.Gordon E.M., Liu P.X., Chen Z.H., et al. Cancer Res. 2000;60:3343–3347. [PubMed] [Google Scholar]
  • 161.Gordon E.M., Cornelio G.H., Lorenzo C.C., et al. Int. J. Oncol. 2004;24:177–185. [PubMed] [Google Scholar]
  • 162.Gordon E.M., Hall F.L. Oncol. Rep. 2005;13:1003–1007. [PubMed] [Google Scholar]
  • 163.Gordon E.M., Levy J.P., Reed R.A., et al. Int. J. Oncol. 2008;33:665–675. [PubMed] [Google Scholar]
  • 164.Gordon E.M., Lopez F.F., Cornelio G.H., et al. Int. J. Oncol. 2006;29:1053–1064. [PubMed] [Google Scholar]
  • 165.Gordon E.M., Chan M.T., Geraldino N., et al. Int. J. Oncol. 2007;30:1297–1307. [PubMed] [Google Scholar]
  • 166.Gordon, E., Hall, F., Beart, Jr.R., et al., in Vector Targeting for Therapeutic Gene Delivery, Curiel, D. and Douglas, J.T., Eds., Wiley, 2003.

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