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. 2002 Nov 12;55(1):23–34. doi: 10.1016/0165-5728(94)90143-0

Alteration of intracerebral cytokine production in mice infected with herpes simplex virus types 1 and 2

Gail Lewandowski a,∗, Monte V Hobbs b, Floyd E Bloom a
PMCID: PMC7119528  PMID: 7962482

Abstract

Previously we reported that a lethal strain of herpes simplex virus type 2 (HSV-2) infects the brain following ocular inoculation of mice. We now demonstrate that HSV-2 mediates an unusual intracellular sequestering of class II major histocompatibility complex (MHC) antigens. With use of an RNase protection assay, we observed a selective inhibition of IFN-γ and IL-6 gene transcription in brains of mice infected with HSV-2. It is likely that the inhibition of cytokine gene expression was mediated through a failure to activate CD4+ lymphocytes. These data suggest that the infecting herpesvirus can influence the profile of intracerebrally produced cytokines, which in turn may determine the outcome of the infection.

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