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. 2020 Oct 14;64(5):709–719. doi: 10.1007/s11427-020-1818-4

ZIKV viral proteins and their roles in virus-host interactions

Moujian Guo 1, Lixia Hui 1, Yiwen Nie 1, Boris Tefsen 2, Ying Wu 1,3,✉
PMCID: PMC7568452  PMID: 33068285

Abstract

The re-emergence of Zika virus (ZIKV) and its associated neonatal microcephaly and Guillain-Barré syndrome have led the World Health Organization to declare a global health emergency. Until today, many related studies have successively reported the role of various viral proteins of ZIKV in the process of ZIKV infection and pathogenicity. These studies have provided significant insights for the treatment and prevention of ZIKV infection. Here we review the current research advances in the functional characterization of the interactions between each ZIKV viral protein and its host factors.

Keywords: ZIKV, viral protein, host-virus interactions, immune response, pathogenicity

Acknowledgements

We thank Xinjie Nie at Tianjin Academy of Fine Arts, School of Experimental Art, Tianjin, China for drawing Figure 1.

Footnotes

Compliance and ethics

The author(s) declare that they have no conflict of interest.

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