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. 2006 Apr 5;8(4):735–757. doi: 10.1111/j.1750-3639.1998.tb00198.x

Transgenic Mouse Models of Alzheimer's Disease and Amyotrophic Lateral Sclerosis

David R Borchelt 1,✉, Philip C Wong 1, Sangram S Sisodia 1, Donald L Price 1
PMCID: PMC8098285  PMID: 9804381

Abstract

Over the past several years, there has been enormous progress in generating transgenic mice that model aspects of human neurodegenerative diseases. These studies build upon the efforts of molecular geneticists who have identified a number of genes that, when mutated, cause familial forms of these diseases. In this review, we focus on the mutations that cause familial forms of Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), and transgenic mouse models that develop clinical and pathological abnormalities resembling those occurring in the human diseases.

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