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. 1980 Dec 1;21(4):482–497. doi: 10.1186/BF03546836

Concentration of Serum Prealbumin (Pr) Protein in Sick Horses and Its Correlation to Blood Leucocyte Count and Albumin Content in Serum

Konsentrasjon av prealbumin (Pr) protein i serum hos syke bester og dets korrelasjon til antall leucocyter i blod og albumininnhold i serum

Nils Ek 1,
PMCID: PMC8317751  PMID: 6784457

Abstract

Studies of Pr protein concentrations in sera of sick horses were carried out using Mancini et al.’s (1965) immunodiffusion technique. Relative values against a chosen standard of 100 % were determined for a total of 102 horses. Horses with acute infections had Pr protein values significantly above the normal. The highest individual Pr protein value recorded in this group was 202. Horses suffering from acute laminitis and malignant tumours also had increased Pr protein values.

There was a positive correlation between the Pr protein value and the blood leucocyte count and a negative correlation between the Pr protein value and the albumin content in serum.

Keywords: horse, serum, prealbumin (Pr) protein concentration

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References

  1. Breeze E G, Nicholls J M, Veitch J, Seltnem G E, Mc Pherson E A, Lawson G. K. H. Serum antitrypsin activity in horses with chronic pulmonary disease. Vet. Rec. 1977;101:146–149. doi: 10.1136/vr.101.7.130. [DOI] [Google Scholar]
  2. Brsend M. Genetics of horse acidic prealbumins. Genetics. 1970;65:495–503. doi: 10.1093/genetics/65.3.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Corbella E. First results of quantitative protease-inhibitors evaluation in equine pathology. Atti Soc. Ital. Sci. vet. 1975;29:315–318. [Google Scholar]
  4. Dimopoullos, G. T.: Plasma proteins. In Clinical Biochemistry of Domestic Animals. 2nd Ed., J. J. Kaneko & C.. E. Cornelius, eds. Acad. Press, New York and London 1970.
  5. Ek N. Studies of electrophoresis on cellulose acetate membrane of serum proteins from normal horses, sheep and pigs. Acta vet. scand. 1970;11:295–304. doi: 10.1186/BF03547989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ek N, Brsend M. Quantitative comparisons of acidic prealbumin (Pr) phenotypes in horses. Acta vet. scand. 1980;21:380–388. doi: 10.1186/BF03546870. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ganrot P O. Obstructive lung disease and trypsin inhibitors in α1-antitrypsin deficiency. Scand. J. clin. Lab. Invest. 1967;19:205–208. doi: 10.3109/00365516709090627. [DOI] [PubMed] [Google Scholar]
  8. Harris, C. C., A. Primack & M. H. Cohen: Elevated alpha-1-antitrypsin levels in lung cancer patients. Cancer (Philad.) 1974, 34, 280–281. [DOI] [PubMed]
  9. Kueppers F. Genetically determined differences in the response of alpha-antitrypsin levels in human serum to typhoid vaccine. Hum. Genet. 1968;6:207–214. doi: 10.1007/BF00291864. [DOI] [PubMed] [Google Scholar]
  10. Mancini G, Carbonara A O, Heremans J F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965;2:235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  11. Ohlson K. Neutral leucocyte proteases and elastase inhibited by plasma alpha-/-antitrypsin. Scand. J. clin. Lab. Invest. 1971;28:251–253. doi: 10.3109/00365517109095696. [DOI] [PubMed] [Google Scholar]
  12. Schalm, O. W.: Veterinary Hematology. Lea & Febiger, Philadelphia 1967.
  13. Snedecor, G. W. & W. G. Cochran: Statistical Methods. Iowa State Univ. Press, Ames, Iowa, USA 1967.
  14. Thorèn-Tolling, K.: Serum protein variations with pathologic conditions by horses and dogs. Svensk Vet.-Tidn. 1977, 20, 917–927.

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