The authors wish to make the following corrections to this paper [1]:
For Table 1, reference [1] has been changed to [64]; reference [2] has been changed to [72]; reference [3] has been changed to [73]; reference [4] has been changed to [82]; reference [5] has been changed to [123]; reference [6] has been changed to [83]; reference [7] has been changed to [92]; reference [8] has been changed to [95]; reference [9] has been changed to [98]. The corrected Table 1 showed as below:
Table 1.
Effect of targeting PRMTs on NMD phenotypes.
| PRMT | Method | Model | Effect on NMD Phenotype |
|---|---|---|---|
| General methyltransferase inhibitor | AdOx | Hela cells | Rescues nuclear import of FUS mutants (R524S, R522G, R525L) [64] |
| General methyltransferase inhibitor | AdOx | Primary rat hippocampal neurons | Rescues nuclear import of FUS mutant (P525L) [64] |
| General methyltransferase inhibitor | AdOx | Primary motor neurons | Diminishes cytoplasmic FUS mutants (R521H, R521G, R521C) [72] |
| General methyltransferase inhibitor | AdOx | ALS patient-derived lymphoblastoid cells | Rescues nuclear import of FUS mutant (R518G) [73] |
| PRMT1 | siRNA KD | Hela cells | Partial rescue of nuclear import of FUS mutant (P525L) [64] |
| PRMT1 | KO | MEF | Diminishes cytoplasmic FUS mutants (R521H, R521G, R521C) [72] |
| PRMT1 | siRNA KD | HEK293 | Diminishes cytoplasmic FUS mutants (R521H, R521G, R521C) [72] |
| PRMT1 | siRNA KD | Primary motor neurons | Increases cytoplasmic FUS mutants (R521H, R521G, R521C) [72] |
| PRMT1 | Inhibitor (AMI-1) | ALS patient-derived lymphoblastoid cells | Rescues nuclear import of FUS mutant (R518G) [73] |
| PRMT1 | shRNA KD | Cortical neurons | Enhances neurite shortening by FUS-R521C under oxidative stress [82] |
| PRMT1 | Overexpression | Cortical neurons | Prevents neurite shortening by FUS-R521C under oxidative stress [82] |
| PRMT1 | Inhibitor (MS023) | NSC-34 | Abrogates PR15-induced toxicity [123] |
| DART1 (PRMT1/PRMT8 ortholog) |
siRNA KD | Drosophila | Enhances neurodegeneration of eyes induced by wild-type FUS or FUS-R521H [73] |
| DART1 (PRMT1/PRMT8 ortholog) |
siRNA KD | Drosophila | Enhances neurodegeneration of eyes induced by wild-type FUS or FUS-P525L [83] |
| PRMT5 | Inhibitor (CMP5 or HLCL65) | Mouse memory T cells | Suppresses memory T cell expansion [92] |
| PRMT5 | Inhibitor (CMP5) or shRNA KD | Human memory T cells | Suppresses memory T cell activation and expansion, partly through downregulation of IL-2 [92] |
| PRMT5 | Inhibitor (CMP5) | OVA-induced DTH mouse | Suppresses T cell-mediated inflammatory response [92] |
| PRMT5 | Inhibitor (HLCL65) | MOG-induced EAE mouse | Suppresses clinical signs of EAE through diminishing T cell-mediated inflammatory response [92] |
| PRMT5 | CD4+ T-cell specific KO | MOG-induced EAE mouse | Suppresses clinical signs of EAE through diminishing T cell-mediated inflammatory response [95] |
| PRMT6 | Overexpression | MN-1 | Exacerbates cytotoxicity due to polyglutamine-expanded AR [98] |
| DART8 (PRMT6 ortholog) |
RNAi KD | Drosophila | Suppresses neurodegenerative phenotype due to polyglutamine-expanded AR [98] |
The authors apologize for any inconvenience caused and state that the scientific conclusions are unaffected. The original publication has also been updated.
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Reference
- 1.Lee J., An S., Lee S.-J., Kang J.-S. Protein Arginine Methyltransferases in Neuromuscular Function and Diseases. Cells. 2022;11:364. doi: 10.3390/cells11030364. [DOI] [PMC free article] [PubMed] [Google Scholar]
