Radiographic Phenotypes Affect the Risk of Inhaled Corticosteroid-Associated Pneumonia in Patients with COPD

Abstract

Purpose

Few studies have reported the association between the radiographic characteristics and the development of pneumonia in patients with chronic obstructive pulmonary disease (COPD) treated with inhaled corticosteroids (ICSs). Our study aimed to assess the effect of radiographic phenotypes on the risk of pneumonia in patients treated with ICSs.

Patients and Methods

This study retrospectively analysed all patients with COPD treated with ICSs in a subset of the Korea Chronic Obstructive Pulmonary Disorders Subgroup Study registry between January 2017 and December 2019. The association between radiographic phenotypes including the presence and severity of emphysema, airway wall thickening, or bronchiectasis on chest computed tomography were determined visually/qualitatively and the risk of pneumonia was analyzed using the Cox regression model.

Results

Among the 90 patients with COPD treated with ICSs, 41 experienced pneumonia more than once during the median follow-up of 29 (interquartile range, 8–35) months. In univariate Cox regression analysis, older age, longer use of ICSs, use of fluticasone propionate or metered dose inhaler, and severe exacerbation events increased the risk of pneumonia. In multivariate analysis, the presence of emphysema (adjusted hazard ratio [aHR]=3.73, P=0.033), severity measured using the visual sum score (mild-to-moderate, aHR=8.58, P=0.016; severe, aHR=3.58, P=0.042), Goddard sum score (mild-to-moderate, aHR=3.31, P=0.058; severe, aHR=5.38, P=0.014), and the upper lobe distribution of emphysema (aHR=3.76, P=0.032) were associated with a higher risk of pneumonia. Subtypes of centrilobular and panlobular emphysema had a higher risk of pneumonia compared with paraseptal emphysema (aHR=3.98, P=0.033; HR=3.91, P=0.041 vs HR=2.74, P=0.304). The presence of bronchiectasis (aHR=2.41, P=0.02) and emphysema/bronchiectasis overlap phenotype (aHR=2.19, P=0.053) on chest CT was a risk factor for pneumonia in this population. However, severity of bronchiectasis and the presence or severity of bronchial wall thickening according to the visual sum score were not associated with the risk of pneumonia.

Conclusion

Among patients with COPD treated with ICSs, radiographic phenotypes including the presence of emphysema, bronchiectasis or emphysema/bronchiectasis overlap phenotype, severity with emphysema, subtypes of centrilobular or panlobular emphysema, and upper lobe distribution of emphysema may help predict the risk of pneumonia.

Introduction

Chronic obstructive pulmonary disease (COPD) is characterized by cough, sputum production, progressive dyspnea, and airflow obstruction.¹ The Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends inhaled corticosteroids (ICSs) combined with bronchodilators to reduce exacerbation rates in patients in GOLD groups C and D, COPD patients with blood eosinophil levels of 300 cells/μL or higher, at least 2 moderate exacerbations per year or a hospitalization from AECOPD, history of asthma, or who remain breathless.^1–3 However, ICSs increase the risk of pneumonia in patients with COPD^4–7 according to their pharmacokinetic characteristics.⁸ Differences in the molecular structures of ICS formulations alter their relative potency ratios and durations of action.^9,10 The local pharmacokinetic rate and degree of absorption in the airways and lungs depend on ICSs’ intrinsic physicochemical properties.^8,11 For example, the prolonged presence of slowly dissolving particles of fluticasone propionate in the airway epithelial lining fluid compared to budesonide may cause protracted local immunosuppression.^12,13 Moreover, phagocytosis of lipophilic ICS particles by airway/alveolar macrophages might lead to impaired macrophage function,¹² possibly contributing to increased bacterial colonization in COPD.¹⁴ This can impair the clearance of airway pathogens, leading to airway/lung colonization by pathogens, which may further develop into pneumonia.

Considering the presence of anatomical abnormalities in the lungs or thorax of patients with COPD, the airway parenchyma is at risk of respiratory infections.^15,16 Some studies have attempted to determine COPD phenotypes by investigating the morphological findings observed on chest computed tomography (CT) scans,^17,18 including the presence of pulmonary emphysema,¹⁷ bronchial wall thickening,¹⁹ small airway disease,²⁰ and bronchiectasis.²¹ Among these morphological findings, the degree of airflow limitation and presence of emphysema are independently associated with the development of severe pneumonia in patients with COPD.²²

However, it remains unclear how a group of patients with a particular chest CT phenotype would be at greater risk of pneumonia in COPD. Emphysema causes significant changes in the central and peripheral airway structures, resulting in considerable airflow limitations or subsequent air trapping due to the loss of elastic recoil in the air sacs.²³ The quotient between residual lung volume and total lung capacity is subject to an increase from 25% in healthy subjects to nearly 80% in patients with severe emphysema.²⁴ This change in lung volume entails the development of asymmetric breathing cycles with considerably prolonged exhalation times.²⁵ Inhaled aerosol boluses also undergo enhanced dispersion in patients with emphysema.^26,27 Furthermore, lung deposition of aerosol particles in patients with varying degrees of airway obstruction and healthy individuals has also shown that the central to peripheral lung deposition ratio increases with disease severity.^28,29

With regard to this physiology, we hypothesized that radiographic phenotypes, such as emphysema, bronchial wall thickening, or bronchiectasis, may act as risk factors for pneumonia in COPD patients treated with ICSs. Our study aimed to assess the effect of radiographic phenotypes on the risk of pneumonia in patients treated with ICSs.

Materials and Methods

This study followed the guidelines presented by the Strengthening the Reporting of Observational Studies in Epidemiology statement.³⁰

Study Design and Participants

This retrospective study assessed all patients with COPD using ICSs in a subset of the Korea Chronic Obstructive Pulmonary Disorders Subgroup Study registry, which consisted of patients recruited from the Seoul Metropolitan Government–Seoul National University Boramae Medical Center and Seoul National University Hospital (SNUH) between January 2017 and December 2019.

We included the patients with a smoking history of more than 10 pack-years, who were treated with a single or combination of ICS therapy with bronchodilators for at least 6 months, and who underwent chest CT during the follow-up period. Indications for ICS treatment among COPD patients are those with moderate or severe/very severe COPD, blood eosinophil levels of 300 cells/μL or higher, at least 2 moderate exacerbations or a hospitalization per year from AECOPD, or who remain breathless.^1–3 The ICSs were classified as follows: inhaled forms of fluticasone propionate, fluticasone furoate, budesonide, ciclesonide, and beclomethasone. The ICS used the longest during the follow-up period was designated as the representative ICS. Previous ICS was defined as exposure for at least 6 months immediately prior to representative ICS treatment. After the eligible patients were classified into two groups according to the presence or absence of pneumonia, the risk ratio for pneumonia was analyzed. Pneumonia was confirmed radiologically and clinically diagnosed. Radiological diagnostic criteria were defined as the presence of a new infiltrate on a chest radiography or reference to “pneumonia” or “bronchopneumonia” in the radiographic report. Clinical diagnostic criteria were defined as the presence of respiratory symptoms or signs with abnormal laboratory test results such as leukocytosis, elevated inflammatory markers, compatible chest imaging, or history of treatment with antibiotics.³¹

Baseline information, including age, sex, body mass index, smoking history, modified Medical Research Council dyspnea scale (mMRC), respiratory comorbidities, other underlying comorbidities, and spirometric examination, were obtained. COPD severity was assessed using the GOLD stage and ABCD classification. Clinical features, including adjuvant treatments, and annual acute exacerbation history were collected. Moderate and severe exacerbation were defined as an exacerbation leading to treatment with antibiotics or systemic glucocorticoids and an exacerbation resulting in hospitalization or death, respectively.^7,32 The characteristics of ICSs, including treatment duration, dose, and formulation types, including metered dose inhalers (MDIs) or disc powder inhalers (DPIs), were obtained.

Chest Computed Tomography (CT) Phenotypes

COPD phenotypes were defined as emphysema, airway thickening, and bronchiectasis on CT, according to the Fleischner Society criteria.³³ The absence or presence and involvement of these findings on CT were assessed using a pulmonary lobe-based visual grading system.³⁴ Emphysema, airway wall thickening, and bronchiectasis were visually graded as absent (score=0) or present (score=1) for each of the following five lobes: right upper lobe (RUL), right middle lobe (RML), right lower lobe (RLL), left upper lobe (LUL), and left lower lobe (LLL). A total score ranging from 0 to 5 was calculated by summing the five separate scores for each lobe.³⁴ Subsequently, three degrees of severity were obtained by categorizing each CT finding as follows: grade 0, absent (total score=0); grade 1, mild to moderate (total score=1–2); and grade 2, severe (total score=3–5). The lobe-based distribution of emphysema was divided into upper lobes containing RUL, RML, and LUL, or lower lobes containing RLL and LLL, based on a visual sum score of 3 or higher. Additionally, the presence and extent of emphysema were scored using a Goddard classification.³⁵ Each involved lobe was visually scored for the percentage affected by emphysema (0=0%, 1=1–25%, 2=26–50%, 3=51–75%, 4≥75%). A total score ranging from 0 to 20 was calculated by summing the five separate scores for each lobe. The severity of emphysema was classified into four categories: grade 0, absent (total score=0); grade 1, mild (total score=1–3); grade 2, moderate (total score=4–6); and grade 3, severe (total score ≥7).³⁴ The percentage ratio of low attenuation area to corresponding lung area (LAA%) on CT has been categorized into three categories: grade 1, low (<3%); grade 2, medium (3–10%); and grade 3, high (10%). In particular, high severity (>10%) of LAA% was defined as predominant emphysema, and the emphysema/bronchiectasis overlap was defined when the presence of predominant emphysema and bronchiectasis coexisted.³⁶ The basic morphological types of COPD (centrilobular emphysema [CLE], paraseptal emphysema [PSE], and panlobular emphysema [PLE]) and all the above scoring assessments on CT were independently evaluated by a pulmonologist and a radiologist. The interobserver agreement of the CT assessment using the k-statistic was good (k statistic, 0.75).

Statistical Analyses

The primary endpoint was the comparison of the risk of pneumonia according to the CT phenotypes.

Data are presented as means with standard deviations or medians with standard errors and numbers with percentages for continuous and categorical variables, respectively. Student’s t-test was used to test independent samples of continuous, normally distributed data, whereas the Wilcoxon rank-sum test was used to examine continuous, skewed data. The chi-squared or Fisher’s exact test was used to analyze categorical data. Kaplan–Meier curves and Log rank tests were performed to compare the time to the first pneumonia event in the absence or presence of emphysema. We performed univariate and multivariate Cox regression analyses to compare the association between pneumonia and CT phenotypes in patients with COPD treated with ICSs. Clinically relevant factors were adjusted for in the multivariate analysis. Three models were constructed. Model 1 included demographic factors such as age, sex, BMI, smoking amount, mMRC grade and post-bronchodilator responsiveness (BDR) FEV₁(L) as covariates. Model 2 included clinical characteristics of ICS such as use of fluticasone propionate, ICS dose, and ICS formulation and all covariates in Model 1. Model 3 added severe exacerbation event to all covariates in Model 2. We used SPSS Statistics (version 27.0; IBM Corp., Armonk, NY, USA) for the statistical analyses.

Results

Among the 222 patients with COPD aged ≥40 years, 132 (105, did not use ICSs; 13, had a smoking history of <10 pack-years; 14, did not undergo chest CT) were excluded. Finally, 90 eligible patients were assigned to the non-pneumonia (n=49) and pneumonia (n=41) groups (Figure S1). The median follow-up duration was 29 [interquartile range (IQR), 8–35] months in eligible patients. The median interval durations between ICS initiation and CT acquisition or ICS initiation and pulmonary function tests were 14.4 [IQR, 0–34] months or 1.9 [IQR, 0–14] months, respectively. Among the patients with pneumonia, the median interval duration between chest CT and pneumonia event was 4.6 [IQR, 0–31] months, and median frequency of pneumonia event was 1.9 [IQR, 1–5].

Baseline Characteristics and Clinical Features

The baseline characteristics of the included patients are presented in Table 1. There were significant differences in age and respiratory or underlying comorbid diseases between the pneumonia and non-pneumonia groups. Patients with pneumonia were more likely to be older than those without pneumonia. Regarding comorbidities, the pneumonia group comprised more patients with hypertension, whereas the non-pneumonia group comprised more patients with asthma, asthma and COPD overlap, rhinitis, or sinusitis. The pneumonia group had lower predicted FEV₁ (%) and FEV₁/FVC (%) than the non-pneumonia group. There was no significant difference in mMRC grade, GOLD stage, serum total IgE level, blood eosinophil level, or the proportion of blood eosinophil levels higher than 300 cells/μL between the two groups except the classification by the ABCD assessment tool. The pneumonia group contained more patients with groups C and D, whereas the non-pneumonia group contained more patients with groups A and B.

Table 1.

Baseline Characteristics of COPD Patients Treated with Inhaled Corticosteroid Containing Therapy

	Total (N=90)	No Pneumonia (n=49)	Pneumonia (n=41)	P-value
Age, years	66 (0.9)	63.69 (9.81)	68.73 (7.11)	0.007
Male	83 (92.2)	46 (93.9)	37 (90.2)	0.522
BMI, kg/m2	23.52 (0.37)	23.51 (3.67)	23.53 (3.41)	0.977
Smoking history				0.166
Never smoker	10 (11.11)	5 (10.2)	5 (12.2)
Former smoker	61 (67.78)	30 (61.2)	31 (75.6)
Current smoker	19 (21.11)	14 (28.6)	5 (12.1)
Smoking amount, pack-years	38.7 (3.1)	35.27 (24.52)	42.76 (33.5)	0.225
mMRC grade				0.409
0–1	48 (53.4)	25 (51)	23 (56.1)
2	32 (35.6)	20 (40.8)	12 (29.3)
3–4	10 (11.1)	4 (8.2)	6 (14.6)
Respiratory comorbidity
Asthma	9 (10)	6 (12.2)	3 (7.3)	0.438
ACO	22 (24.4)	16 (32.7)	6 (14.6)	0.048
NTM–PD	8 (8.9)	4 (8.2)	4 (9.8)	0.791
Bronchiectasis	15 (16.7)	6 (12.2)	9 (22)	0.219
Tuberculous destroyed lung	26 (28.9)	14 (28.6)	12 (29.3)	0.942
Interstitial lung disease	1 (1.1)	1 (2)	0 (0)	0.358
Lung cancer	5 (5.6)	1 (2)	4 (9.8)	0.112
Rhinitis or sinusitis	15 (16.7)	12 (24.5)	3 (7.3)	0.029
Other comorbid disease
Hypertension	19 (21.1)	6 (12.2)	13 (31.7)	0.024
Diabetes mellitus	19 (21.1)	10 (20.4)	9 (22)	0.858
Chronic kidney disease	3 (3.3)	1 (2)	2 (4.9)	0.455
Chronic liver disease	4 (4.4)	1 (2)	3 (7.3)	0.226
Cerebrovascular disease	9 (10)	3 (6.1)	6 (14.6)	0.18
Cardiovascular disease	23 (25.6)	12 (24.5)	11 (26.8)	0.8
Malignancy other than lung cancer	9 (10)	3 (6.1)	6 (14.6)	0.358
Gastroesophageal reflux disease	2 (2.2)	2 (4.1)	0	0.191
Peptic ulcer	1 (1.1)	1 (2)	0	0.358
GOLD stage				0.212
1–2	63 (70)	37 (75.5)	26 (63.4)
3–4	27 (30)	12 (24.5)	15 (36.6)
ABCD classification				<0.0001
A-B	73 (54.4)	47 (95.9)	26 (63.4)
C-D	17 (18.9)	2 (4.1)	15 (36.6)
Baseline spirometry
FEV1, predicted %	60.26 (1.99)	63.57 (18.98)	56.29 (18.2)	0.068
FVC, predicted %	90.03 (1.78)	91.82 (16.67)	87.9 (17.15)	0.277
FEV1/FVC, predicted %	46.39 (1.37)	48.63 (12.85)	43.71 (12.73)	0.072
DLCO, predicted %	81.08 (2.55)	83.73 (22.94)	77.9 (25.53)	0.257
Serum total IgE level, UI/mL	401.59 (136.38)	326.41 (156.62)	1234.11 (233.23)	0.560
Blood eosinophil count, cells/µL	262.26 (22.85)	292.44 (37.06)	226.19 (22.82)	0.132
Blood eosinophil count >300 µL, n (%)	26 (28.9)	15 (30.6)	11 (26.8)	0.693

Note: Data presented as n (%) or mean (SD) and median (SE).

Abbreviations: BMI, body mass index; mMRC, modified Medical Research Council dyspnea scale; COPD, chronic obstructive pulmonary disease; ACO, asthma and COPD overlap; DLCO, diffusing capacity of the lungs for carbon monoxide; FVC, forced vital capacity; FEV₁, forced expiratory volume in 1 second; NTM–PD, nontuberculous mycobacteria pulmonary disease.

The clinical features of the patients treated with ICS are presented in Table 2. The median duration of ICS treatment was significantly longer in the pneumonia group than in the non-pneumonia group (25.1 months vs 19.7 months). The single or combination therapy with fluticasone furoate (33%) was most commonly used in both groups, followed by those of budesonide (30%), and comparable distribution was found in both groups. However, the pneumonia group was more likely treated with single or combination therapy of fluticasone propionate than the non-pneumonia group (27% vs 8.2%, P=0.018). DPIs (64.4%) were more commonly used in most formulation types of ICSs than MDIs (35.6%). More than 73% of the patients in both groups had been exposed to ICS single or combination therapy prior to treatment with dominant ICS single or combination therapy. Oral or inhaled bronchodilators and systemic steroid were similarly used in both groups during the stable period. The pneumonia group had a significantly higher annual rate and number of moderate, severe, or moderate-to-severe exacerbations than the non-pneumonia group.

Table 2.

Clinical Features of COPD Patients Treated with Inhaled Corticosteroid Containing Therapy

	Total (N=90)	No Pneumonia (N=49)	Pneumonia (N=41)	P-value
Follow-up duration, months	29.09 (0.72)	27.55 (8.01)	30.93 (4.46)	0.014
Duration of dominant ICS use, months	22.13 (1.05)	19.69 (9.84)	25.05 (9.43)	0.01
Dominant ICS type
Fluticasone propionate	15 (16.66)	4 (8.2)	11 (26.8)	0.018
Fluticasone furoate	30 (33.33)	18 (36.7)	12 (29.3)	0.454
Budesonide	27 (30)	17 (34.7)	10 (24.4)	0.288
Othersa	18 (20)	10 (20.4)	8 (19.5)	0.916
ICS dose				0.08
Low-to-medium dose	82 (91.11)	47 (95.9)	35 (85.4)
High dose	8 (8.89)	2 (4.1)	6 (14.6)
Inhaler formulation				0.852
Disc powder inhaler	58 (64.44)	32 (65.3)	26 (63.4)
Metered dose inhaler	32 (35.56)	17 (34.7)	15 (36.6)
Previous dominant ICS type
Fluticasone propionate	21 (31.82)	11 (22.4)	10 (24.4)	0.828
Fluticasone furoate	17 (25.76)	8 (16.3)	9 (22)	0.497
Budesonide	22 (33.33)	13 (26.5)	9 (22)	0.615
Othersa	6 (9.09)	3 (6.1)	3 (7.3)	0.821
Combined therapy
SABA	55 (61.11)	26 (53.1)	29 (70.7)	0.087
LAMA	2 (2.2)	2 (4.1)	0 (0)	0.191
LABA	38 (42.2)	17 (34.7)	21 (51.2)	0.114
LABA/LAMA	35 (38.9)	15 (30.6)	20 (48.8)	0.078
Bronchodilator oral agent	32 (35.56)	16 (32.7)	16 (39)	0.529
Systemic steroid	15 (16.67)	6 (12.2)	9 (22)	0.219
Annual acute exacerbation
Moderate exacerbation events, n (%)	36 (40)	11 (22.45)	25 (60.98)	<0.001
Severe exacerbation events, n (%)	15 (6.7)	3 (6.12)	12 (29.27)	0.003
Moderate-to-severe exacerbation events, n (%)	43 (47.8)	12 (24.49)	31 (75.61)	<0.001
Total annual events, mean (SD)	1.03 (1.8)	0.53 (1.72)	1.63 (1.71)	0.003

Notes: ^aCiclesonide and beclomethasone. Data presented as n (%) or mean (SD) and median (SE).

Abbreviations: ICS, inhaled corticosteroid; SABA, short-acting β2-agonist; LABA, long-acting β2-agonist; LAMA, long-acting muscarinic antagonist; SD, standard deviation; SE, standard error.

Risk Factors of Pneumonia

In the univariate Cox regression model for clinical factors, older age, history of lung cancer or hypertension, treatment with single or combination therapy of fluticasone propionate, use of MDIs or long-acting beta-agonist (LABA) and long-acting muscarinic antagonist (LAMA) combination therapy, history of previous ICS use, lower predicted and post-BDR FEV₁ (L), lower DLCO (L) or (%), and greater annual number of severe exacerbation events were associated with an increased risk of pneumonia in patients with COPD (Table 3).

Table 3.

Hazard Ratio of Pneumonia in COPD Patients Treated with Inhaled Corticosteroid Therapy in Univariable Cox Regression Model

	Univariable Cox Regression Model
	HR (95% CI)	P-value
Age	1.043 (1.005–1.083)	0.026
Male	1.525 (0.539–4.313)	0.426
BMI	0.941 (0.858–1.033)	0.205
Smoking history		0.663
Never smoker	Reference
Former smoker	1.121 (0.433–2.903)	0.815
Current smoker	1.719 (0.474–6.243)	0.410
Smoking amount, pack-years	1.001 (0.993–1.01)	0.735
mMRC grade		0.140
0–1	Reference
2	0.878 (0.431–1.786)	0.719
3–4	2.354 (0.914–6.060)	0.076
Respiratory comorbidity
Asthma	1.504 (0.454–4.982)	0.504
ACO	0.607 (0.252–1.463)	0.266
NTM-PD	0.713 (0.245–2.08)	0.536
Bronchiectasis	1.371 (0.643–2.925)	0.415
Tuberculous destroyed lung	0.717 (0.346–1.486)	0.371
Interstitial lung disease	0.049 (0–79,731,637.033)	0.780
Lung cancer	3.496 (1.214–10.069)	0.020
Rhinitis or sinusitis	0.567 (0.174–1.85)	0.347
Other comorbid disease
Hypertension	2.385 (1.195–4.76)	0.014
Diabetes mellitus	1.059 (0.5–2.242)	0.882
Chronic kidney disease	2.469 (0.585–10.423)	0.219
Chronic liver disease	0.962 (0.271–3.412)	0.952
Cerebrovascular disease	1.348 (0.561–3.242)	0.505
Cardiovascular disease	1.351 (0.668–2.732)	0.403
Malignancy other than lung cancer	1.791 (0.746–4.297)	0.192
Gastroesophageal reflux disease	0.047 (0–736.146)	0.535
Peptic ulcer	–	–
GOLD stage		0.616
1–2	Reference
3–4	1.519 (0.795–2.903)	0.205
ABCD classification
A-B	Reference
C-D	1.452 (0.738–2.857)	0.28
Baseline spirometric examination
Predicted value
FEV1, L	0.442 (0.209–0.934)	0.032
FEV1, %	0.986 (0.966–1.006)	0.170
FVC, L	0.71 (0.475–1.062)	0.095
FVC, %	0.987 (0.969–1.006)	0.190
FEV1/FVC, %	0.985 (0.96–1.011)	0.250
Post-bronchodilator value
FEV1, L	0.469 (0.248–0.888)	0.020
FEV1, %	0.985 (0.968–1.002)	0.088
FVC, L	0.722 (0.492–1.06)	0.097
FVC, %	0.987 (0.969–1.006)	0.181
FEV1/FVC, %	0.983 (0.96–1.006)	0.148
DLCO, L	0.889 (0.828–0.955)	0.001
DLCO, %	0.984 (0.97–0.997)	0.019
Serum total IgE level (UI/mL)	1	0.993
Eosinophil count (µL)	0.998 (0.997–1)	0.056
Eosinophil count >300µL	0.651 (0.323–1.312)	0.23
Duration of ICS use	1.018 (0.982–1.055)	0.333
Dominant ICS type
Fluticasone propionate	5.748 (2.572–12.843)	<0.001
Fluticasone furoate	0.541 (0.272–1.074)	0.079
Budesonide	0.616 (0.3–1.263)	0.186
Othersa	1.332 (0.61–2.909)	0.472
ICS dose (High)	0.832 (0.343–2.017)	0.683
ICS formulation type (MDI)	2.145 (1.111–4.139)	0.023
Previous ICS use	0.48 (0.232–0.996)	0.049
Previous dominant ICS type
Fluticasone propionate	2.06 (0.983–4.317)	0.055
Fluticasone furoate	0.7 (0.332–1.478)	0.349
Budesonide	0.479 (0.227–1.007)	0.052
Othersa	1.054 (0.322–3.455)	0.931
Adjuvant therapy
SABA	1.337 (0.677–2.642)	0.403
LAMA	1.252 (0.664–2.360)	0.488
LABA	–	–
LABA/LAMA	2.317 (1.224–4.385)	0.01
Bronchodilator oral agent	1.378 (0.725–2.616)	0.328
Systemic steroid	1.469 (0.696–3.101)	0.313
Annual acute exacerbation
Moderate exacerbation events	1.049 (0.547–2.011)	0.886
Severe exacerbation events	2.115 (1.045–4.278)	0.037
Moderate-to-severe exacerbation events	1.411 (0.679–2.932)	0.356
Mean of annual total exacerbation events	1.097 (0.961–1.253)	0.168

Notes: ^aCiclesonide and beclomethasone. Data were analyzed with univariable and multivariable Cox regression models and are presented as adjusted hazard ratio (95% confidence interval).

Abbreviations: BMI, body mass index; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CT, computed tomography; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; HR, hazard ratio; ICS, inhaled corticosteroid; LABA, long-acting β2-agonist; LAMA, long-acting muscarinic antagonist; mMRC, modified Medical Research Council dyspnea scale.

Association of CT Phenotypes with Pneumonia

The univariate Cox regression model of chest CT phenotypes associated with pneumonia risk is shown in Table 4. Regarding emphysema, the presence of emphysema, mild-to-moderate grade in the visual sum score or severe grade in the Goddard sum score, higher LAA% score, subtypes of centrilobular or PLE, and distribution in the upper lobe were significantly associated with a higher risk of pneumonia compared to the absence of emphysema. However, the time to the first pneumonia event did not significantly differ between the absence and presence of emphysema (Figure S2). The presence of bronchiectasis was significantly associated with a higher risk of pneumonia compared to the absence of bronchiectasis, whereas the severity according to the visual sum score was not associated with an increased risk of pneumonia. Furthermore, the emphysema/bronchiectasis overlap phenotype was significantly associated with increased pneumonia risk. The presence or severity of bronchial wall thickening according to the visual sum score was not associated with the risk of pneumonia.

Table 4.

Association of Pneumonia and CT Phenotype in COPD Patients Treated with Inhaled Corticosteroid Therapy in Univariable Cox Regression Model

	Univariable Cox Regression Model
	HR (95% CI)	P-value
Emphysema	3.924 (1.374–11.206)	0.011
Visual sum score		0.033
Absence	1
Mild to moderate (<3 lobes)	5.206 (1.136–23.853)	0.034
Severe (3–5 lobes)	3.877 (1.352–11.116)	0.012
Goddard sum score		0.014
Absence	1
Mild to moderate (≤50%)	2.976 (0.987–8.979)	0.053
Severe (<50%)	5.511 (1.850–16.416)	0.002
LAA% score		0.007
Low (<3%)	1
Medium (3–10%)	1.539 (0.522–4.538)	0.434
High (<10%)	3.712 (1.391–9.907)	0.009
Subtype		0.043
Absence	1
CLE	3.768 (1.257–11.293)	0.018
PSE	2.206 (0.395–12.302)	0.367
PLE	4.766 (1.565–14.513)	0.006
Lobe distribution
Absence	1
Upper lobe	3.953 (1.385–11.283)	0.01
Lower lobe	2.99 (1.24–7.207)	0.015
Bronchial wall thickening	2.555 (0.892–7.314)	0.081
Visual sum score		0.019
Absence	1
Mild to moderate (<3 lobes)	2.362 (0.956–5.838)	0.063
Severe (3–5 lobes)	0.818 (0.366–1.826)	0.624
Bronchiectasis	2.382 (1.243–4.566)	0.009
Visual sum score		0.155
Absence	1
Mild to moderate (<3 lobes)	1.77 (0.83–3.77)	0.136
Severe (3–5 lobes)	1.98 (0.91–4.28)	0.083
Emphysema/bronchiectasis overlap	2.81 (1.42–5.54)	0.003

Notes: Data were analyzed with univariable Cox regression and are presented as Cox regression coefficient and 95% confidence interval.

Abbreviations: LAA%, low attenuation area; CLE, centrilobular emphysema; PSE, paraseptal emphysema; PLE, panlobular emphysema.

The multivariate Cox regression model of chest CT phenotypes associated with the risk of pneumonia is shown in Table 5, and Figure 1 depicts an overview of Model 1. The presence of emphysema showed significantly higher risk of pneumonia than the absence of emphysema in the adjusted models (Model 1, adjusted hazard ratio [aHR]=3.73 [95% confidence interval (CI)=1.11–12.53], P=0.033; Model 2, aHR=3.69 [95% CI=1.07–12.81], P=0.039; Model 3, aHR=3.72 [95% CI=1.07–12.97], P=0.039). In visual sum score in emphysema, the mild-to-moderate and severe grades had a higher risk of pneumonia even after adjusting clinically relevant factors in Models 1–3 compared to the absence of emphysema (mild-to-moderate, aHR=8.58 [95% CI=1.49–49.37], P=0.016; severe, aHR=3.58 [95% CI=1.05–12.25], P=0.042 in Model 1). The Goddard sum score with severe grade was associated with a higher risk of pneumonia compared to the absence of emphysema, whereas there was no significant association between mild-to-moderate grade and risk of pneumonia (mild-to-moderate, aHR=3.31 [95% CI=0.96–11.37], P=0.058; severe, aHR=5.38 [95% CI=1.41–20.44], P=0.014 in Model 1). Among the emphysema subtypes, CLE was significantly associated with increased pneumonia after adjusting for clinically relevant variables in Models 1–3, and PLE showed a significantly increased hazard ratio only in Model 1. The upper lobe distribution of emphysema was significantly associated with increased risk of pneumonia in Models 1–3, whereas the lower lobe distribution of emphysema was not. However, the severity of LAA% score for emphysema was not associated with an increased risk of pneumonia. The median frequency of the pneumonia was 1 (IQR, 1–2) in the pneumonia group. There were no significant differences in the clinical features of patients with pneumonia according to the absence or presence of emphysema, including pneumonia type, severity of pneumonia, involvement or pattern on chest CT, and mortality (Table S1).

Table 5.

Association of Pneumonia and CT Phenotype in COPD Patients Treated with Inhaled Corticosteroid Therapy in Multivariable Cox Regression Model

	Model 1*		Model 2*		Model 3*
	HR (95% CI)	P-value	HR (95% CI)	P-value	HR (95% CI)	P-value
Emphysema	3.73 (1.11–12.53)	0.033	3.69 (1.07–12.81)	0.039	3.72 (1.07–12.97)	0.039
Visual sum score		0.045		0.058		0.055
Mild to moderate (<3 lobes)	8.58 (1.49–49.37)	0.016	7.86 (1.35–45.79)	0.022	8.46 (1.39–51.37)	0.02
Severe (3–5 lobes)	3.58 (1.05–12.25)	0.042	3.59 (1.03–12.55)	0.045	3.63 (1.03–12.79)	0.044
Goddard sum score		0.046		0.061		0.061
Mild to moderate (≤50%)	3.31 (0.96–11.37)	0.058	3.4 (0.97–11.9)	0.056	3.39 (0.96–11.9)	0.057
Severe (<50%)	5.38 (1.41–20.44)	0.014	5.29 (1.33–21.04)	0.018	5.31 (1.33–21.19)	0.018
%LAA score		0.182		0.189		0.190
Medium (3–10%)	1.34 (0.38–4.72)	0.653	1.25 (0.34–4.56)	0.738	1.25 (0.34–4.65)	0.737
High (<10%)	2.66 (0.69–10.22)	0.153	2.49 (0.63–9.81)	0.191	2.5 (0.63–9.87)	0.191
Subtype		0.076		0.089		0.088
CLE	3.98 (1.12–14.14)	0.033	3.91 (1.08–14.22)	0.038	3.94 (1.08–14.35)	0.038
PSE	2.74 (0.4–18.76)	0.304	3.09 (0.44–21.91)	0.260	3.16 (0.44–22.77)	0.254
PLE	3.91 (1.06–14.45)	0.041	3.75 (0.99–14.18)	0.051	3.75 (0.99–14.19)	0.052
Lobe distribution
Upper lobea	3.76 (1.12–12.58)	0.032	3.74 (1.09–12.87)	0.037	3.76 (1.09–13.01)	0.036
Lower lobeb	2.42 (0.87–6.72)	0.09	2.4 (0.85–6.81)	0.1	2.4 (0.84–6.81)	0.101
Bronchiectasis	2.41 (1.15–5.05)	0.02	2.55 (1.19–5.46)	0.016	2.56 (1.2–5.49)	0.015
Visual sum score		0.161		0.154		0.152
Mild to moderate (<3 lobes)	2.06 (0.91–4.65)	0.082	1.99 (0.84–4.67)	0.116	2 (0.84–4.75)	0.115
Severe (3–5 lobes)	1.82 (0.76–4.36)	0.181	2.08 (0.85–5.06)	0.107	2.08 (0.85–5.06)	0.107
Emphysema/bronchiectasis overlap	2.19 (0.99–4.85)	0.053	3.34 (1.44–7.72)	0.005	3.33 (1.44–7.72)	0.005

Notes: Model 1* Age, sex, BMI, smoking amount (packyears), mMRC grade, pulmonary function test (post-BDR FEV₁L). Model 2* Model 1+ FP use, ICS dose, ICS formulation. Model 3* Model 2+ severe exacerbation event. ^aRight upper lobe, right middle lobe, left upper lobe, left lingula. ^bRight lower lobe, left lower lobe. Data were analyzed with multivariable Cox regression and are presented as Cox regression coefficient and 95% confidence interval.

Abbreviations: BDR, bronchodilator responsiveness; LAA%, low attenuation area; CLE, centrilobular emphysema; PSE, paraseptal emphysema; PLE, panlobular emphysema.

Figure 1.

Adjusted hazard ratio of pneumonia according to the radiographic phenotypes.

Note: Data were analyzed with Cox regression with adjustment for the covariates in Model 1.

Abbreviations: aHR, adjusted hazard ratio; CLE, centrilobular emphysema; PSE, paraseptal emphysema; PLE, panlobular emphysema.

There was significantly higher association with the risk of pneumonia in the presence of bronchiectasis on chest CT according to Models 1–3 in multivariate Cox regression analysis (Model 1, aHR=2.41 [95% CI=1.15–5.05], P=0.02; Model 2, aHR=2.55 [95% CI=1.19–5.46], P=0.016; Model 3, aHR=2.56 [95% CI=1.2–5.49), P=0.015). Furthermore, the emphysema/bronchiectasis overlap phenotype was significantly associated with increased pneumonia risk in Model 2 and 3 (Model 1, aHR=2.19 [95% CI=0.99–4.85], P=0.053; Model 2, aHR=3.34 [95% CI=1.44–7.72], P=0.005; Model 3, aHR=3.33 [95% CI=1.44–7.72], P=0.005). However, we found no association between severity according to the visual sum score in bronchiectasis on chest CT and the risk of pneumonia.

Discussion

Our study suggests that radiographic phenotypes including the presence of emphysema, its severity measured based on the visual and Goddard sum score affect ICS with the risk of pneumonia in patients with COPD. Additionally, subtypes of centrilobular and PLE had a higher risk of pneumonia compared with PSE, and emphysema distributed in the upper lobe had a higher risk of pneumonia compared with that in the lower lobe. Moreover, bronchiectasis and emphysema/bronchiectasis overlap phenotype were risk factors for pneumonia in this population.

Several medical studies have reported the enhanced dispersion of inhaled aerosol boluses in emphysema.^26,27 Enhancement of aerosol bolus dispersion becomes trapped in the extent of alveolar destruction and peripheral air sacs for a prolonged duration, causing a considerable contribution of intra-alveolar particles and air to more spreading and alteration of the particle peak.^37,38 From a physical point of view, in similar severity of emphysema, bolus dispersion continuously increases from centrilobular and PSE to PLE.²⁵ With regard to this physiology, it was assumed that ICS dispersion also increases from CLE and PSE to PLE. However, in our study, PLE and CLE had a higher risk of pneumonia compared to PSE, considering the difficulty in distinguishing confluent or advanced destructive CLE from PLE on chest CT and the relatively low prevalence of PLE with alpha-1-proteinase inhibitor deficiency in Korea compared to Europe or America.³⁹ Furthermore, as applied to ICS particles in previous deposition studies, the size of the alveolar structures has a significant effect on ICS particle deposition, as increased intra-alveolar distances and particulate substances consume additional time to reach the alveolar walls.^40,41 Therefore, ICS particle deposition may increase according to the severity of emphysema, and these were associated with an increased risk of pneumonia.

There are several lung deposition data points for inhaled aerosols in subjects with explicitly defined emphysema and COPD. The cross-sectional area of the airways will be smaller; thus, an inhaled aerosol is more at risk to the effect in the more proximal parts of the lung in COPD.⁴² The central-to-peripheral ratios of aerosol deposition are slightly greater in patients with emphysema with COPD than in healthy subjects.⁴³ Furthermore, pulmonary bioavailability following particle inhalation was modeled as a function of the regional lung deposition pattern and mucociliary clearance rate. Mucociliary clearance is reduced in patients with chronic obstructive lung disease⁴⁴ and in smokers.⁴⁵ Therefore, increased central lung deposition and reduced mucociliary clearance rate of ICS particles in emphysema in patients with COPD may lengthen the duration of settlement of ICSs in the lung, which may, in turn, be associated with pneumonia development.

COPD with concomitant bronchiectasis contributed to not only development of high severity of emphysema but also susceptibility to infection or pneumonia. The prevalence of bronchiectasis in patients with COPD ranges from 4% to 72%, and one consistent finding has been the association between the advanced stages or increased severity of emphysema-predominant COPD and the higher prevalence of bronchiectasis.^36,46 Furthermore, the COPD and bronchiectasis overlap phenotype has clinical implications for more frequent severe exacerbations and chronic bronchial infections.^47,48 It seems that the airway epithelial cells have dysfunction of regeneration and differentiation in patients with COPD and bronchiectasis, which results in reducing the airway barrier and makes it susceptible to infections.^49,50

Typical radiological findings of combined pulmonary fibrosis and emphysema (CPFE) in chest CT are emphysema in the upper lobes, and fibrosis and honeycombing in the lower lobes of the lung.^51,52 A retrospective study reported that CPFE might be classified as an emphysema-dominant or fibrosis-dominant phenotype according to the severity of LAA% or pulmonary fibrosis on chest CT.⁵³ Although the incidence of interstitial lung disease was only 1.1% and CPFE was not quantitatively evaluated in our study, the result of the present study can be applied with caution, limited to patients with emphysema-dominant CPFE treated with inhaled bronchodilator.

Despite these interesting findings, this study has some limitations. First, our retrospective study included a small number of patients with COPD using ICSs, and it may not be free of selection bias, although the common risk factors for pneumonia in COPD are compatible with those of previous reports. Therefore, to generalize the potential pneumonia risk according to the radiological phenotypes of ICS therapy in COPD, more studies with larger numbers of patients are required. Second, our study did not include patients diagnosed with COPD who did not use ICS. However, as acknowledged by the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency,⁵⁴ ICS treatment increases the risk of pneumonia in COPD.^4–6 Third, the extent and severity of radiographic subtypes were measured using semi-quantitative methods, rather than recently updated quantitative computational methods, because of retrospective data collection. Moreover, the role of small airway dysfunction was not assessed. However, consistent findings through analyses using semi-quantitative methods may reflect the usefulness of relatively crude radiographic assessment. Fourth, the respiratory comorbidities that could affect radiographic phenotypes, including tuberculous destroyed lung, interstitial pneumonia, or lung cancer, were not excluded. However, quantitative evaluation studies on chest CT may be necessary to further clarify the association in the future.

Conclusion

Among patients with COPD treated with ICSs, radiographic phenotypes including the presence of emphysema, bronchiectasis or emphysema/bronchiectasis overlap phenotype, severity with emphysema, subtypes of CLE or PLE, and upper lobe distribution of emphysema measured on chest CT may help predict the risk of pneumonia. Therefore, when physicians consider the risk–benefit of ICSs in patients with COPD, radiographic characteristics and exacerbation history, eosinophil count, and combined asthma may be other determining factors.

Funding Statement

This research did not receive any specific grant from funding agencies in the public, commercial, or not-profit sectors.

Abbreviations

BDR, bronchodilator responsiveness; CLE, centrilobular emphysema; COPD, chronic obstructive pulmonary disease; CT, computed tomography; DLCO, diffusing capacity of the lungs for carbon monoxide; FEV₁, forced expiratory volume in 1 s; FVC, forced vital capacity; ICS, inhaled corticosteroid; LAA%, low attenuation area; mMRC, modified Medical Research Council dyspnea scale; PLE, panlobular emphysema; PSE, paraseptal emphysema; SD, standard deviation; SE, standard error.

Data Sharing Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Ethics approval and informed consent

This study was conducted in accordance with the ethical guidelines of the Declaration of Helsinki in 1975. This study was approved by the IRB Committee of Seoul National University Seoul Metropolitan Government (SNU-SMG) Boramae Medical Center and SNUH, and the requirement for informed consent from study subjects for access to electronic medical records was waived (IRB No. 10-2020-37).

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Disclosure

All authors report no conflicts of interest in relation to this work.