Furnishing the cachexia landscape: A year of research in JCSM

2022 was another eventful year for the ‘Journal of Cachexia, Sarcopenia and Muscle’ (JCSM). This year was already the 12th time that JCSM was published together with the ‘Society on Sarcopenia, Cachexia, and Wasting Disorders (SCWD)’ and Wiley. Editor‐in‐chief of JCSM continues to be Prof. Dr. Stefan Anker (Berlin, Germany) together with Co‐Editor‐in‐chief Prof. Dr. Stephan von Haehling (Göttingen, Germany) and Senior Consulting Editor Prof. Dr. Andrew Coats (Rome, Italy). The editorial office is run by Monika Diek and Corinna Denecke.

JCSM continues to be a place for cachexia, sarcopenia and muscle wasting research, but also research on how the human body, cells and animals are affected by cancer, chronic obstructive pulmonary disease, diabetes, heart failure, HIV/Aids, malnutrition, ageing and other chronic conditions. The versatile range of up‐to‐date research covers basic science and preclinical studies as much as current clinical research outcomes—additionally giving researchers the opportunity to summarize and discuss recent publications in editorials. Many researchers, nurses, clinicians, dieticians, pharmacists, physiotherapists, biologists and many others that are interested in these topics read and share the articles of the journal, that is, currently published 6 times per year. In 2022 (until November), at total of 775 000 downloads from around the world of articles published at JCSM were already counted. Most downloads came from China (173 681), the United States (118 306), Japan (66 147), the United Kingdom (36 452) and South Korea (33 629) (Figure  1 ), but also smaller countries like Switzerland (7305), Hong Kong (15 980) and Panama (147).

Figure 1.

JCSM articles downloaded by country in 2022. *Between January and November 2022

The number of submissions to JCSM increases every year (so far 833 this year), and only with the great help of many associate editors and reviewers that we want to thank for their important work, it is possible to continue to publish scientific articles and maintain the 2021 impact factor of JCSM at 12.063. The best cited research articles so far since JCSM started are shown in Table 1 . The best cited article so far continues to be an editorial by von Haehling and Anker ¹ (‘Cachexia as a major underestimated and unmet medical need: facts and numbers’) with 640 citations. But also the best cited paper from 2019 by Cederholm et al. ² (‘GLIM criteria for the diagnosis of malnutrition—a consensus report from the global clinical nutrition community’) has already been cited 421 times so far until September 2022 and therefore takes the place as the second most cited article of all time. In total, the top 20 cited articles from 2019, 2020 and 2021 (Tables 2 , 3 , 4 ) have now already been cited: 2022, 898 and 295 times.

Table 1.

Top 20 cited articles of all time from JCSM (according to ‘Web of Science’, 28 September 2022)

Rank	Authors	Title	Article type	Times cited
1 1	von Haehling S, Anker SD	Cachexia as a major underestimated and unmet medical need: facts and numbers	Editorial Material	640
2 2	Cederholm T, Jensen GL, Correia MITD, Gonzalez MC, Fukushima R, Higashiguchi T, Baptista G, Barazzoni R, Blaauw R, Coats AJS, Crivelli AN, Evans DC, Gramlich L, Fuchs‐Tarlovsky V, Keller H, Llido L, Malone A, Mogensen KM, Morley JE, Muscaritoli M, Nyulasi I, Pirlich M, Pisprasert V, de van der Schueren MAE	GLIM criteria for the diagnosis of malnutrition—a consensus report from the global clinical nutrition community	Article	421
3 3	Malmstrom TK, Miller DK, Simonsick EM, Ferrucci L, Morley JE	SARC‐F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes	Article	374
4 4	Anker SD, Morley JE, von Haehling S	Welcome to the ICD‐10 code for sarcopenia	Editorial Material	325
5 5	Buckinx F, Landi F, Cesari M, Fielding RA, Visser M, Engelke K, Maggi S, Dennison E, Al‐Daghri NM, Allepaerts S, Bauer J, Bautmans I, Brandi ML, Bruyere O, Cederholm T, Cerreta F, Cherubini A, Cooper C, Cruz‐Jentoft A, McCloskey E, Dawson‐Hughes B, Kaufman JM, Laslop A, Petermans J, Reginster JY, Rizzoli R, Robinson S, Rolland Y, Rueda R, Vellas B, Kanis JA	Pitfalls in the measurement of muscle mass: a need for a reference standard	Article	317
6 6	Morley JE, Anker SD, von Haehling S	Prevalence, incidence, and clinical impact of sarcopenia: facts, numbers, and epidemiology—update 2014	Editorial Material	291
7 7	Tieland M, Trouwborst I, Clark BC	Skeletal muscle performance and ageing	Review	276
8 8	Yeung SSY, Reijnierse EM, Pham VK, Trappenburg MC, Lim WK, Meskers CGM, Maier AB	Sarcopenia and its association with falls and fractures in older adults: a systematic review and meta‐analysis	Review	248
9 9	Montano‐Loza AJ, Angulo P, Meza‐Junco J, Prado CMM, Sawyer MB, Beaumont C, Esfandiari N, Ma M, Baracos VE	Sarcopenic obesity and myosteatosis are associated with higher mortality in patients with cirrhosis	Article	233
10 10	Dalton JT, Barnette KG, Bohl CE, Hancock ML, Rodriguez D, Dodson ST, Morton RA, Steiner MS	The selective androgen receptor modulator GTx‐024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double‐blind, placebo‐controlled phase II trial	Article	224
11 11	Bowen TS, Schuler G, Adams V	Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training	Review	220
12 12	Wakabayashi H, Sakuma K	Rehabilitation nutrition for sarcopenia with disability: a combination of both rehabilitation and nutrition care management	Review	207
13 13	Patel SS, Molnar MZ, Tayek JA, Ix JH, Noori N, Benner D, Heymsfield S, Kopple JD, Kovesdy CP, Kalantar‐Zadeh K	Serum creatinine as a marker of muscle mass in chronic kidney disease: results of a cross‐sectional study and review of literature	Review	205
14 14	Bauer J, Morley JE, Schols AMWJ, Ferrucci L, Cruz‐Jentoft AJ, Dent E, Baracos VE, Crawford JA, Doehner W, Heymsfield SB, Jatoi A, Kalantar‐Zadeh K, Lainscak M, Landi F, Laviano A, Mancuso M, Muscaritoli M, Prado CM, Strasser F, von Haehling S, Coats AJS, Anker SD	Sarcopenia: a time for action. An SCWD position paper	Article	201
15 15	Fanzani A, Conraads VM, Penna F, Martinet W	Molecular and cellular mechanisms of skeletal muscle atrophy: an update	Review	196
16 16	von Haehling S, Anker SD	Prevalence, incidence and clinical impact of cachexia: facts and numbers—update 2014	Editorial Material	193
17 17	Elkina Y, von Haehling S, Anker SD, Springer J	The role of myostatin in muscle wasting: an overview	Review	192
18 18	Cesari M, Fielding RA, Pahor M, Goodpaster B, Hellerstein M, Van Kan GA, Anker SD, Rutkove S, Vrijbloed JW, Isaac M, Rolland Y, M'Rini C, Aubertin‐Leheudre M, Cedarbaum JM, Zamboni M, Sieber CC, Laurent D, Evans WJ, Roubenoff R, Morley JE, Vellas B	Biomarkers of sarcopenia in clinical trials—recommendations from the International Working Group on Sarcopenia	Article	175
19 19	von Haehling S, Morley JE, Anker SD	An overview of sarcopenia: facts and numbers on prevalence and clinical impact	Editorial Material	174
20 20	Lenk K, Schuler G, Adams V	Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training	Review	169

Table 2.

Top 20 cited articles published 2021 (according to ‘Web of Science’, 28 September 2022)

Rank	Authors	Title	Article type	Times cited
1 21	Mollazadeh H, Tavana E, Fanni G, Bo S, Banach M, Pirro M, von Haehling S, Jamialahmadi T, Sahebkar A	Effects of statins on mitochondrial pathways	Review	38
2 22	Petermann‐Rocha F, Balntzi V, Gray SR, Lara J, Ho FK, Pell JP, Celis‐Morales C	Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta‐analysis	Review	23
3 23	Wilkinson TJ, Miksza J, Yates T, Lightfoot CJ, Baker LA, Watson EL, Zaccardi F, Smith AC	Association of sarcopenia with mortality and end‐stage renal disease in those with chronic kidney disease: a UK Biobank study	Article	18
4 24	Gil S, Jacob Filho W, Shinjo SK, Ferriolli E, Busse AL, Avelino‐Silva TJ, Longobardi I, de Oliveira Júnior GN, Swinton P, Gualano B, Roschel H	Muscle strength and muscle mass as predictors of hospital length of stay in patients with moderate to severe COVID‐19: a prospective observational study	Article	17
5 25	Bortone I, Sardone R, Lampignano L, Castellana F, Zupo R, Lozupone M, Moretti B, Giannelli G, Panza F	How gait influences frailty models and health‐related outcomes in clinical‐based and population‐based studies: a systematic review	Review	17
6 26	Martin A, Freyssenet D	Phenotypic features of cancer cachexia‐related loss of skeletal muscle mass and function: lessons from human and animal studies	Review	16
7 27	Cheval B, Sieber S, Maltagliati S, Millet GP, Formánek T, Chalabaev A, Cullati S, Boisgontier MP	Muscle strength is associated with COVID‐19 hospitalization in adults 50 years of age or older	Article	14
8 28	Ding H, Chen S, Pan X, Dai X, Pan G, Li Z, Mai X, Tian Y, Zhang S, Liu B, Cao G, Yao Z, Yao X, Gao L, Yang L, Chen X, Sun J, Chen H, Han M, Yin Y, Xu G, Li H, Wu W, Chen Z, Lin J, Xiang L, Hu J, Lu Y, Zhu X, Xie L	Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis	Article	14
9 29	Takenaka Y, Oya R, Takemoto N, Inohara H	Predictive impact of sarcopenia in solid cancers treated with immune checkpoint inhibitors: a meta‐analysis	Review	13
10 30	Xie WQ, He M, Yu DJ, Wu YX, Wang XH, Lv S, Xiao WF, Li YS	Mouse models of sarcopenia: classification and evaluation	Review	13
11 31	Aluganti Narasimhulu C, Singla DK	Amelioration of diabetes‐induced inflammation mediated pyroptosis, sarcopenia, and adverse muscle remodelling by bone morphogenetic protein‐7	Article	13
12 32	Zhang Q, Song MM, Zhang X, Ding JS, Ruan GT, Zhang XW, Liu T, Yang M, Ge YZ, Tang M, Li XR, Qian L, Song CH, Xu HX, Shi HP	Association of systemic inflammation with survival in patients with cancer cachexia: results from a multicentre cohort study	Article	12
13 33	Akazawa N, Kishi M, Hino T, Tsuji R, Tamura K, Hioka A, Moriyama H	Intramuscular adipose tissue in the quadriceps is more strongly related to recovery of activities of daily living than muscle mass in older inpatients	Article	12
14 34	Dodds RM, Murray JC, Granic A, Hurst C, Uwimpuhwe G, Richardson S, Brayne C, Matthews FE, Sayer AA	Prevalence and factors associated with poor performance in the 5‐chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia	Article	12
15 35	Martin L, Muscaritoli M, Bourdel‐Marchasson I, Kubrak C, Laird B, Gagnon B, Chasen M, Gioulbasanis I, Wallengren O, Voss AC, Goldwasser F, Jagoe RT, Deans C, Bozzetti F, Strasser F, Thoresen L, Kazemi S, Baracos V, Senesse P	Diagnostic criteria for cancer cachexia: reduced food intake and inflammation predict weight loss and survival in an international, multi‐cohort analysis	Article	11
16 36	Rosa‐Caldwell ME, Lim S, Haynie WA, Brown JL, Deaver JW, Morena Da Silva F, Jansen LT, Lee DE, Wiggs MP, Washington TA, Greene NP	Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy	Article	11
17 37	Mournetas V, Massouridès E, Dupont JB, Kornobis E, Polvèche H, Jarrige M, Dorval ARL, Gosselin MRF, Manousopoulou A, Garbis SD, Górecki DC, Pinset C	Myogenesis modelled by human pluripotent stem cells: a multi‐omic study of Duchenne myopathy early onset	Article	11
18 38	Busch K, Kny M, Huang N, Klassert TE, Stock M, Hahn A, Graeger S, Todiras M, Schmidt S, Chamling B, Willenbrock M, Groß S, Biedenweg D, Heuser A, Scheidereit C, Butter C, Felix SB, Otto O, Luft FC, Slevogt H, Fielitz J	Inhibition of the NLRP3/IL‐1β axis protects against sepsis‐induced cardiomyopathy	Article	10
19 39	Pötgens SA, Thibaut MM, Joudiou N, Sboarina M, Neyrinck AM, Cani PD, Claus SP, Delzenne NM, Bindels LB	Multi‐compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice	Article	10
20 40	Czigany Z, Kramp W, Lurje I, Miller H, Bednarsch J, Lang SA, Ulmer TF, Bruners P, Strnad P, Trautwein C, von Websky MW, Tacke F, Neumann UP, Lurje G	The role of recipient myosteatosis in graft and patient survival after deceased donor liver transplantation	Article	10

Table 3.

Top 20 cited articles published 2020 (according to ‘Web of Science’, 28 September 2022)

Rank	Authors	Title	Article type	Times cited
1 41	Prado CM, Purcell SA, Laviano A	Nutrition interventions to treat low muscle mass in cancer	Review	102
2 42	Morley JE, Kalantar‐Zadeh K, Anker SD	COVID‐19: a major cause of cachexia and sarcopenia?	Editorial Material	85
3 43	Kirk B, Zanker J, Duque G	Osteosarcopenia: epidemiology, diagnosis, and treatment‐facts and numbers	Editorial Material	84
4 44	Peixoto da Silva S, Santos J, Costa e Silva MP, Gil da Costa RM, Medeiros R	Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia	Review	67
5 45	Kitamura A, Seino S, Abe T, Nofuji Y, Yokoyama Y, Amano H, Nishi M, Taniguchi Y, Narita M, Fujiwara Y, Shinkai S	Sarcopenia: prevalence, associated factors, and the risk of mortality and disability in Japanese older adults	Article	45
6 46	Sipilä S, Törmäkangas T, Sillanpää E, Aukee P, Kujala UM, Kovanen V, Laakkonen EK	Muscle and bone mass in middle‐aged women: role of menopausal status and physical activity	Article	44
7 47	Nishida Y, Nawaz A, Kado T, Takikawa A, Igarashi Y, Onogi Y, Wada T, Sasaoka T, Yamamoto S, Sasahara M, Imura J, Tokuyama K, Usui I, Nakagawa T, Fujisaka S, Kunimasa Y, Tobe K	Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway	Article	41
8 48	Chen LK, Hwang AC, Lee WJ, Peng LN, Lin MH, Neil DL, Shih SF, Loh CH, Chiou ST	Efficacy of multidomain interventions to improve physical frailty, depression and cognition: data from cluster‐randomized controlled trials	Article	38
9 49	Anker MS, Landmesser U, von Haehling S, Butler J, Coats AJS, Anker SD	Weight loss, malnutrition, and cachexia in COVID‐19: facts and numbers	Editorial Material	36
10 50	Weerink L, van der Hoorn A, van Leeuwen BL, de Bock GH	Low skeletal muscle mass and postoperative morbidity in surgical oncology: a systematic review and meta‐analysis	Review	36
11 51	Huang CY, Yang YC, Chen TC, Chen JR, Chen YJ, Wu MH, Jan YT, Chang CL, Lee J	Muscle loss during primary debulking surgery and chemotherapy predicts poor survival in advanced‐stage ovarian cancer	Article	35
12 52	Chiappalupi S, Sorci G, Vukasinovic A, Salvadori L, Sagheddu R, Coletti D, Renga G, Romani L, Donato R, Riuzzi F	Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia	Article	34
13 53	Rong S, Wang L, Peng Z, Liao Y, Li D, Yang X, Nuessler AK, Liu L, Bao W, Yang W	The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?	Review	33
14 54	Sepúlveda‐Loyola W, Osadnik C, Phu S, Morita AA, Duque G, Probst VS	Diagnosis, prevalence, and clinical impact of sarcopenia in COPD: a systematic review and meta‐analysis	Review	32
15 55	Capitanio D, Moriggi M, Torretta E, Barbacini P, De Palma S, Viganò A, Lochmüller H, Muntoni F, Ferlini A, Mora M, Gelfi C	Comparative proteomic analyses of Duchenne muscular dystrophy and Becker muscular dystrophy muscles: changes contributing to preserve muscle function in Becker muscular dystrophy patients	Article	32
16 56	Wakabayashi H, Arai H, Inui A	The regulatory approval of anamorelin for treatment of cachexia in patients with non‐small cell lung cancer, gastric cancer, pancreatic cancer, and colorectal cancer in Japan: facts and numbers	Editorial Material	31
17 57	Sanchez‐Rodriguez D, Locquet M, Reginster JY, Cavalier E, Bruyère O, Beaudart C	Mortality in malnourished older adults diagnosed by ESPEN and GLIM criteria in the SarcoPhAge study	Article	31
18 58	Cespedes Feliciano EM, Popuri K, Cobzas D, Baracos VE, Beg MF, Khan AD, Ma C, Chow V, Prado CM, Xiao J, Liu V, Chen WY, Meyerhardt J, Albers KB, Caan BJ	Evaluation of automated computed tomography segmentation to assess body composition and mortality associations in cancer patients	Article	31
19 59	Zhou H, Meng J, Malerba A, Catapano F, Sintusek P, Jarmin S, Feng L, Lu‐Nguyen N, Sun L, Mariot V, Dumonceaux J, Morgan JE, Gissen P, Dickson G, Muntoni F	Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy	Article	31
20 60	Lurz E, Patel H, Lebovic G, Quammie C, Woolfson JP, Perez M, Ricciuto A, Wales PW, Kamath BM, Chavhan GB, Jüni P, Ng VL	Paediatric reference values for total psoas muscle area	Article	30

Table 4.

Top 20 cited articles published 2019 (according to ‘Web of Science’, 28 September 2022)

Rank	Authors	Title	Article type	Times cited
1 2	Cederholm T, Jensen GL, Correia MITD, Gonzalez MC, Fukushima R, Higashiguchi T, Baptista G, Barazzoni R, Blaauw R, Coats AJS, Crivelli AN, Evans DC, Gramlich L, Fuchs‐Tarlovsky V, Keller H, Llido L, Malone A, Mogensen KM, Morley JE, Muscaritoli M, Nyulasi I, Pirlich M, Pisprasert V, de van der Schueren MAE, Siltharm S, Singer P, Tappenden K, Velasco N, Waitzberg D, Yamwong P, Yu J, Van Gossum A, Compher C	GLIM criteria for the diagnosis of malnutrition—a consensus report from the global clinical nutrition community	Article	421
2 8	Yeung SSY, Reijnierse EM, Pham VK, Trappenburg MC, Lim WK, Meskers CGM, Maier AB	Sarcopenia and its association with falls and fractures in older adults: a systematic review and meta‐analysis	Review	248
3 14	Bauer J, Morley JE, Schols AMWJ, Ferrucci L, Cruz‐Jentoft AJ, Dent E, Baracos VE, Crawford JA, Doehner W, Heymsfield SB, Jatoi A, Kalantar‐Zadeh K, Lainscak M, Landi F, Laviano A, Mancuso M, Muscaritoli M, Prado CM, Strasser F, von Haehling S, Coats AJS, Anker SD	Sarcopenia: a time for action. An SCWD position paper	Article	201
4 61	Wang DXM, Yao J, Zirek Y, Reijnierse EM, Maier AB	Muscle mass, strength, and physical performance predicting activities of daily living: a meta‐analysis	Review	125
5 62	Pin F, Barreto R, Couch ME, Bonetto A, O'Connell TM	Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism	Article	89
6 63	Li ZH, Cai BL, Abdalla BA, Zhu XN, Zheng M, Han PG, Nie QH, Zhang XQ	LncIRS1 controls muscle atrophy via sponging miR‐15 family to activate IGF1‐PI3K/AKT pathway	Article	82
7 64	Suetta C, Haddock B, Alcazar J, Noerst T, Hansen OM, Ludvig H, Kamper RS, Schnohr P, Prescott E, Andersen LL, Frandsen U, Aagaard P, Bülow J, Hovind P, Simonsen L	The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20–93 years	Article	72
8 65	Evans WJ, Hellerstein M, Orwoll E, Cummings S, Cawthon PM	D3‐Creatine dilution and the importance of accuracy in the assessment of skeletal muscle mass	Review	72
9 66	Oost LJ, Kustermann M, Armani A, Blaauw B, Romanello V	Fibroblast growth factor 21 controls mitophagy and muscle mass	Article	71
10 67	Dolan RD, Almasaudi AS, Dieu LB, Horgan PG, McSorley ST, McMillan DC	The relationship between computed tomography‐derived body composition, systemic inflammatory response, and survival in patients undergoing surgery for colorectal cancer	Article	71
11 68	Koppe L, Fouque D, Kalantar‐Zadeh K	Kidney cachexia or protein‐energy wasting in chronic kidney disease: facts and numbers	Editorial Material	69
12 69	Ubachs J, Ziemons J, Minis‐Rutten I, Kruitwagen R, Kleijnen J, Lambrechts S, Olde Damink S, Rensen SS, Van Gorp T	Sarcopenia and ovarian cancer survival: a systematic review and meta‐analysis	Review	62
13 70	Dijksterhuis WPM, Pruijt MJ, van der Woude SO, Klaassen R, Kurk SA, van Oijen MGH, van Laarhoven HWM	Association between body composition, survival, and toxicity in advanced esophagogastric cancer patients receiving palliative chemotherapy	Article	60
14 71	Ramírez‐Vélez R, Correa‐Bautista JE, García‐Hermoso A, Cano CA, Izquierdo M	Reference values for handgrip strength and their association with intrinsic capacity domains among older adults	Article	58
15 72	Anker MS, Holcomb R, Muscaritoli M, von Haehling S, Haverkamp W, Jatoi A, Morley JE, Strasser F, Landmesser U, Coats AJS, Anker SD	Orphan disease status of cancer cachexia in the USA and in the European Union: a systematic review	Article	56
16 73	Naito T, Mitsunaga S, Miura S, Tatematsu N, Inano T, Mouri T, Tsuji T, Higashiguchi T, Inui A, Okayama T, Yamaguchi T, Morikawa A, Mori N, Takahashi T, Strasser F, Omae K, Mori K, Takayama K	Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non‐small‐cell lung cancer	Article	56
17 74	Qazi TH, Duda GN, Ort MJ, Perka C, Geissler S, Winkler T	Cell therapy to improve regeneration of skeletal muscle injuries	Review	55
18 75	Rodriguez‐Mañas L, Laosa O, Vellas B, Paolisso G, Topinkova E, Oliva‐Moreno J, Bourdel‐Marchasson I, Izquierdo M, Hood K, Zeyfang A, Gambassi G, Petrovic M, Hardman TC, Kelson MJ, Bautmans I, Abellan G, Barbieri M, Peña‐Longobardo LM, Regueme SC, Calvani R, De Buyser S, Sinclair AJ	Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus	Article	54
19 76	Okugawa Y, Toiyama Y, Hur K, Yamamoto A, Yin CZ, Ide S, Kitajima T, Fujikawa H, Yasuda H, Koike Y, Okita Y, Hiro J, Yoshiyama S, Araki T, Miki C, McMillan DC, Goel A, Kusunoki M	Circulating miR‐203 derived from metastatic tissues promotes myopenia in colorectal cancer patients	Article	53
20 77	Hughes MC, Ramos SV, Turnbull PC, Rebalka IA, Cao A, Monaco CMF, Varah NE, Edgett BA, Huber JS, Tadi P, Delfinis LJ, Schlattner U, Simpson JA, Hawke TJ, Perry CGR	Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H2O2 emission during impaired oxidative phosphorylation	Article	47

Regarding the most downloaded articles in 2022, the readers mainly focused on articles that were published in 2022 or between 2017 and 2022. The top three downloaded papers from 2022 were (1) ‘Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19’ by Wüst et al. ⁷⁸ (downloaded 11.727 times), (2) ‘Systematic review and meta‐analysis of protein intake to support muscle mass and function in healthy adults’ by Nunes et al. ⁷⁹ (downloaded 10.641 times) and (3) ‘GLIM criteria for the diagnosis of malnutrition—a consensus report from the global clinical nutrition community’ by Cederholm et al. ² (downloaded 6.319 times).

Additionally, celebrating a small jubilee in 2022: the 15th congress of SCWD took place in Lisboa (Portugal) this year. Many researchers and scientists from several different countries met in person and digitally to discuss the newest research with regard to cachexia, muscle wasting and sarcopenia. The participants enjoyed many great talks from experts in the field and vivid panel discussions.

Conflict of interest

All authors declare no conflict of interest.

Fröhlich A.‐K., Diek M., von Haehling S., and Anker M. S. (2022) Furnishing the cachexia landscape: A year of research in JCSM , Journal of Cachexia, Sarcopenia and Muscle, 13, 2763–2771, doi: 10.1002/jcsm.13151.