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. 2022 Dec 19;71(11):2473–2481. doi: 10.1007/s11172-022-3676-y

Evaluation of antiviral activity of terpenophenols and some of their N- and O-derivatives

I Yu Chukicheva 1,✉, E V Buravlev 1, I A Dvornikova 1, I V Fedorova 1, V V Zarubaev 2, A V Slita 2, Ya L Esaulkova 2, A V Kutchin 1
PMCID: PMC9762639  PMID: 36569656

Abstract

A comparative evaluation of the antiviral activity of a number of new and previously synthesized terpenophenols and their N- or O-containing derivatives against the A/Puerto Rico/8/34 (H1N1) virus strain was carried out. 2-Isobornylphenol, 1,2-dihydroxy-6-isobornyl-4-methylbenzene, 2-isobornyl-1,4-benzoquinone, and N-butyl-4-hydroxy-3,5-diisobornylbenzamide showed the highest activity.

Key words: terpenophenols, Mannich bases, hydroxymethyl derivatives, antiviral activity

Footnotes

Based on the materials of the V Russian Conference on Medicinal Chemistry with international participation “MedChem-Russia 2021” (May 16–19, 2022, Volgograd, Russia).

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2473–2481, November, 2022.

This work was performed under financial support of the Russian Foundation for Basic Research (Project No. 20-04-60493).

No human or animal subjects were used in this research.

The authors declare no competing interests.

Contributor Information

I. Yu. Chukicheva, Email: chukichevaiy@mail.ru

V. V. Zarubaev, Email: zarubaev@gmail.com

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