Index of Online Supplemental Material for J. Exp. Med. 10.1084/jem.20072051Hill et al. • Figure S1 Histological evaluation of arthritis in DR4-IE tg mice highlighting proteoglycan changes by safranin O staining (red).
• Figure S2 Splenocytes from DR4-IE tg mice immunized with CithFib (day 70) produce IL-10 after in vitro challenge with CithFib and hFib (50 µg/ml).
• Figure S3 T cells from CithFib-immunized DR4-IE tg mice can induce arthritis after transfer to naive DR4-IE tg hosts that received intraarticular injection of CithFib.
• Figure S4 HLA-DR–restricted immune response to FibαR84Cit in DR4-IE tg mice immunized with CithFib (day 70).
• Figure S5 Citrulline-specific IgG reactivity determined by inhibition.
• Figure S6 Typical mobility shift of CithFib seen by SDS-PAGE.
• Tables S1--S4 (PDF)