Convergent Evolution of Calcineurin Pathway Roles in Thermotolerance and Virulence in Candida glabrata

Supporting Information for Chen et al, 2012

Files in this Data Supplement:

  • Supporting Information - Figures S1-S7 and Tables S1 and S2 (PDF, 7.9 MB)
  • Figure S1 - C. glabrata wild-type cells exhibit a shrunken cell morphology at 40�C in the presence of FK506 or CsA (PDF, 916 KB)
  • Figure S2 - TEM images of C. glabrata wild type (CBS138) and crz1 mutant (YC182) cells grown at 40�C (PDF, 641 KB)
  • Figure S3 - C. glabrata wild type and calcineurin mutant cells exhibit normal cortical actin patch structures. (PDF, 472 KB)
  • Figure S4 - Some C. glabrata clinical isolates exhibit temperature-sensitive growth when exposed to calcineurin inhibitors (PDF, 691 KB)
  • Figure S5 - Virulence of C. glabrata calcineurin and crz1 mutants in murine urinary tract and ocular infection models (PDF, 197 KB)
  • Figure S6 - Pairwise alignment of calcineurin regulators from C. glabrata, S. cerevisiae, and C. albicans (PDF, 703 KB)
  • Figure S7 - Synteny analysis of Rcn1 and Rcn2 (PDF, 1.1 MB)
  • Table S1 - PCR primers (PDF, 919 KB)
  • Table S2 - Genes induced by FK506 but not by calcineurin mutation (PDF, 710 KB)