Published August 20, 2012 // JCB vol. 198 no. 4 561-574
The Rockefeller University Press, doi: 10.1083/jcb.201111136

T granules in human platelets function in TLR9 organization and signaling

• Video 1 TLR9 colocalizes with PDI in distinct punctuate granules in resting human PLTs probed for TLR9.

• Video 2 TLR9 colocalizes with PDI in distinct punctuate granules in resting human PLTs probed for PDI.

• Video 3 Increased TLR9 PLT surface expression results in type C CpG-mediated PLT clumping.

• Video 4 Increased TLR9 PLT surface expression results in type C CpG-mediated PLT clumping.

• Video 5 ODN-activated PLTs do not form thrombi on collagen type IV.

• Video 6 ODN-activated PLTs do not form thrombi on collagen type IV.

• Video 7 ODN-activated PLTs do not form thrombi on collagen type IV.

• Video 8 Shows that type C CpG ODN-activated PRP PLTs do not form thrombi on collagen type IV.

• Video 9 Shows that control ODN-activated PRP PLTs do not form thrombi on collagen type IV.

• Video 10 Shows that type C CpG ODN-activated PRP PLTs form thrombi on collagen type I.

• Video 11 Shows that control ODN-activated PRP PLTs form thrombi on collagen type I.

• Supplemental material (PDF)