Skip to main content
NCBI home page
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 2002 Nov;61(Suppl 2):ii29–ii31. doi: 10.1136/ard.61.suppl_2.ii29

Mesenchymal stem cells. A potential source for skeletal repair

W Fibbe
PMCID: PMC1766715  PMID: 12379617

Full Text

The Full Text of this article is available as a PDF (70.5 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen T. D., Dexter T. M., Simmons P. J. Marrow biology and stem cells. Immunol Ser. 1990;49:1–38. [PubMed] [Google Scholar]
  2. Aubin J. E. Bone stem cells. J Cell Biochem Suppl. 1998;30-31:73–82. [PubMed] [Google Scholar]
  3. Barry F. P., Boynton R. E., Haynesworth S., Murphy J. M., Zaia J. The monoclonal antibody SH-2, raised against human mesenchymal stem cells, recognizes an epitope on endoglin (CD105). Biochem Biophys Res Commun. 1999 Nov;265(1):134–139. doi: 10.1006/bbrc.1999.1620. [DOI] [PubMed] [Google Scholar]
  4. Barry F., Boynton R., Murphy M., Haynesworth S., Zaia J. The SH-3 and SH-4 antibodies recognize distinct epitopes on CD73 from human mesenchymal stem cells. Biochem Biophys Res Commun. 2001 Nov 30;289(2):519–524. doi: 10.1006/bbrc.2001.6013. [DOI] [PubMed] [Google Scholar]
  5. Campagnoli C., Roberts I. A., Kumar S., Bennett P. R., Bellantuono I., Fisk N. M. Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood. 2001 Oct 15;98(8):2396–2402. doi: 10.1182/blood.v98.8.2396. [DOI] [PubMed] [Google Scholar]
  6. Caplan A. I. The mesengenic process. Clin Plast Surg. 1994 Jul;21(3):429–435. [PubMed] [Google Scholar]
  7. Deans R. J., Moseley A. B. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol. 2000 Aug;28(8):875–884. doi: 10.1016/s0301-472x(00)00482-3. [DOI] [PubMed] [Google Scholar]
  8. Dreiser R. L., Maheu E., Guillou G. B. Sensitivity to change of the functional index for hand osteoarthritis. Osteoarthritis Cartilage. 2000;8 (Suppl A):S25–S28. doi: 10.1053/joca.2000.0332. [DOI] [PubMed] [Google Scholar]
  9. Erices A., Conget P., Minguell J. J. Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol. 2000 Apr;109(1):235–242. doi: 10.1046/j.1365-2141.2000.01986.x. [DOI] [PubMed] [Google Scholar]
  10. Fernández M., Simon V., Herrera G., Cao C., Del Favero H., Minguell J. J. Detection of stromal cells in peripheral blood progenitor cell collections from breast cancer patients. Bone Marrow Transplant. 1997 Aug;20(4):265–271. doi: 10.1038/sj.bmt.1700890. [DOI] [PubMed] [Google Scholar]
  11. Franceschi R. T., Wang D., Krebsbach P. H., Rutherford R. B. Gene therapy for bone formation: in vitro and in vivo osteogenic activity of an adenovirus expressing BMP7. J Cell Biochem. 2000 Jun 6;78(3):476–486. doi: 10.1002/1097-4644(20000901)78:3<476::aid-jcb12>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  12. Friedenstein A. J., Deriglasova U. F., Kulagina N. N., Panasuk A. F., Rudakowa S. F., Luriá E. A., Ruadkow I. A. Precursors for fibroblasts in different populations of hematopoietic cells as detected by the in vitro colony assay method. Exp Hematol. 1974;2(2):83–92. [PubMed] [Google Scholar]
  13. Galotto M., Berisso G., Delfino L., Podesta M., Ottaggio L., Dallorso S., Dufour C., Ferrara G. B., Abbondandolo A., Dini G. Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients. Exp Hematol. 1999 Sep;27(9):1460–1466. doi: 10.1016/s0301-472x(99)00076-4. [DOI] [PubMed] [Google Scholar]
  14. Gerson S. L. Mesenchymal stem cells: no longer second class marrow citizens. Nat Med. 1999 Mar;5(3):262–264. doi: 10.1038/6470. [DOI] [PubMed] [Google Scholar]
  15. Gronthos S., Simmons P. J. The biology and application of human bone marrow stromal cell precursors. J Hematother. 1996 Feb;5(1):15–23. doi: 10.1089/scd.1.1996.5.15. [DOI] [PubMed] [Google Scholar]
  16. Gutiérrez-Rodríguez M., Reyes-Maldonado E., Mayani H. Characterization of the adherent cells developed in Dexter-type long-term cultures from human umbilical cord blood. Stem Cells. 2000;18(1):46–52. doi: 10.1634/stemcells.18-1-46. [DOI] [PubMed] [Google Scholar]
  17. Horwitz E. M., Prockop D. J., Fitzpatrick L. A., Koo W. W., Gordon P. L., Neel M., Sussman M., Orchard P., Marx J. C., Pyeritz R. E. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med. 1999 Mar;5(3):309–313. doi: 10.1038/6529. [DOI] [PubMed] [Google Scholar]
  18. Horwitz E. M., Prockop D. J., Gordon P. L., Koo W. W., Fitzpatrick L. A., Neel M. D., McCarville M. E., Orchard P. J., Pyeritz R. E., Brenner M. K. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood. 2001 Mar 1;97(5):1227–1231. doi: 10.1182/blood.v97.5.1227. [DOI] [PubMed] [Google Scholar]
  19. Krebsbach P. H., Kuznetsov S. A., Satomura K., Emmons R. V., Rowe D. W., Robey P. G. Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts. Transplantation. 1997 Apr 27;63(8):1059–1069. doi: 10.1097/00007890-199704270-00003. [DOI] [PubMed] [Google Scholar]
  20. Lazarus H. M., Haynesworth S. E., Gerson S. L., Rosenthal N. S., Caplan A. I. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. Bone Marrow Transplant. 1995 Oct;16(4):557–564. [PubMed] [Google Scholar]
  21. Lichtman M. A. The ultrastructure of the hemopoietic environment of the marrow: a review. Exp Hematol. 1981 Apr;9(4):391–410. [PubMed] [Google Scholar]
  22. Mackay A. M., Beck S. C., Murphy J. M., Barry F. P., Chichester C. O., Pittenger M. F. Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow. Tissue Eng. 1998 Winter;4(4):415–428. doi: 10.1089/ten.1998.4.415. [DOI] [PubMed] [Google Scholar]
  23. Mareschi K., Biasin E., Piacibello W., Aglietta M., Madon E., Fagioli F. Isolation of human mesenchymal stem cells: bone marrow versus umbilical cord blood. Haematologica. 2001 Oct;86(10):1099–1100. [PubMed] [Google Scholar]
  24. Nakahara H., Dennis J. E., Bruder S. P., Haynesworth S. E., Lennon D. P., Caplan A. I. In vitro differentiation of bone and hypertrophic cartilage from periosteal-derived cells. Exp Cell Res. 1991 Aug;195(2):492–503. doi: 10.1016/0014-4827(91)90401-f. [DOI] [PubMed] [Google Scholar]
  25. Nathanson M. A. Bone matrix-directed chondrogenesis of muscle in vitro. Clin Orthop Relat Res. 1985 Nov;(200):142–158. [PubMed] [Google Scholar]
  26. Owen M. Marrow stromal stem cells. J Cell Sci Suppl. 1988;10:63–76. doi: 10.1242/jcs.1988.supplement_10.5. [DOI] [PubMed] [Google Scholar]
  27. Pereira R. F., O'Hara M. D., Laptev A. V., Halford K. W., Pollard M. D., Class R., Simon D., Livezey K., Prockop D. J. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1142–1147. doi: 10.1073/pnas.95.3.1142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Pittenger M. F., Mackay A. M., Beck S. C., Jaiswal R. K., Douglas R., Mosca J. D., Moorman M. A., Simonetti D. W., Craig S., Marshak D. R. Multilineage potential of adult human mesenchymal stem cells. Science. 1999 Apr 2;284(5411):143–147. doi: 10.1126/science.284.5411.143. [DOI] [PubMed] [Google Scholar]
  29. Prockop D. J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science. 1997 Apr 4;276(5309):71–74. doi: 10.1126/science.276.5309.71. [DOI] [PubMed] [Google Scholar]
  30. Reyes M., Lund T., Lenvik T., Aguiar D., Koodie L., Verfaillie C. M. Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells. Blood. 2001 Nov 1;98(9):2615–2625. doi: 10.1182/blood.v98.9.2615. [DOI] [PubMed] [Google Scholar]
  31. Tavassoli M., Friedenstein A. Hemopoietic stromal microenvironment. Am J Hematol. 1983 Sep;15(2):195–203. doi: 10.1002/ajh.2830150211. [DOI] [PubMed] [Google Scholar]
  32. Wakitani S., Imoto K., Yamamoto T., Saito M., Murata N., Yoneda M. Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage. 2002 Mar;10(3):199–206. doi: 10.1053/joca.2001.0504. [DOI] [PubMed] [Google Scholar]
  33. Wakitani Shigeyuki, Yamamoto Tetsuya. Response of the donor and recipient cells in mesenchymal cell transplantation to cartilage defect. Microsc Res Tech. 2002 Jul 1;58(1):14–18. doi: 10.1002/jemt.10111. [DOI] [PubMed] [Google Scholar]
  34. Zvaifler N. J., Marinova-Mutafchieva L., Adams G., Edwards C. J., Moss J., Burger J. A., Maini R. N. Mesenchymal precursor cells in the blood of normal individuals. Arthritis Res. 2000 Aug 31;2(6):477–488. doi: 10.1186/ar130. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES