Abstract
The pathological features of 12 acinar cell neoplasms of the pancreas are described; these comprise 11 carcinomas, of which seven were pure acinar cell growths and four were mixed acinar and ductal carcinomas, and one adenoma. These tumors occurred in a series of 105 during the period 162-75. Thrombotic endocarditis developed in three out the 11 carcinoma cases. The distinctive histological features of these neoplasms and the means of differentiating them from anaplastic carcinomas and certain other carcinomas, for example, islet cell carcinoma, oat cell carcinomas, and carcinoid tumours, are discussed. The poor prognosis of pancreatic cancers is emphasized, and reasons are put forward for believing that future epidemiological studies may need to take account of the histological types of pancreatic carcinoma.
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- Cubilla A. L., Fitzgerald P. J. Morphological patterns of primary nonendocrine human pancreas carcinoma. Cancer Res. 1975 Aug;35(8):2234–2248. [PubMed] [Google Scholar]
- GLENNER G. G., MALLORY G. K. The cystadenoma and related nonfunctional tumors of the pancreas; pathogenesis, classification, and significance. Cancer. 1956 Sep-Oct;9(5):980–996. doi: 10.1002/1097-0142(195609/10)9:5<980::aid-cncr2820090519>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
- Garcia H., Pelfrene A., Love L. A. Letter: Pancreatic acinar adenomas. Arch Pathol. 1975 Nov;99(11):621–621. [PubMed] [Google Scholar]
- LEACH W. B. Carcinoma of the pancreas; a clinical and pathologic analysis of 39 autopsied cases. Am J Pathol. 1950 Mar;26(2):333–347. [PMC free article] [PubMed] [Google Scholar]
- Longnecker D. S., Crawford B. G. Hyperplastic nodules and adenomas of exocrine pancreas in azaserine-treated rats. J Natl Cancer Inst. 1974 Aug;53(2):573–577. doi: 10.1093/jnci/53.2.573. [DOI] [PubMed] [Google Scholar]
- Longnecker D. S., Curphey T. J. Adenocarcinoma of the pancreas in azaserine-treated rats. Cancer Res. 1975 Aug;35(8):2249–2258. [PubMed] [Google Scholar]
- MILLER J. R., BAGGENSTOSS A. H., COMFORT M. W. Carcinoma of the pancreas; effect of histological types and grade of malignancy on its behavior. Cancer. 1951 Mar;4(2):233–241. doi: 10.1002/1097-0142(195103)4:2<233::aid-cncr2820040205>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
- Moldow R. E., Connelly R. R. Epidemiology of pancreatic cancer in Connecticut. Gastroenterology. 1968 Dec;55(6):677–686. [PubMed] [Google Scholar]
- OSBORNE R. R. Functioning acinous cell carcinoma of the pancreas accompanied with widespread focal fat necrosis. Arch Intern Med (Chic) 1950 Jun;85(6):933–943. doi: 10.1001/archinte.1950.00230120042004. [DOI] [PubMed] [Google Scholar]
- Pour P., Krüger F. W., Althoff J., Cardesa A., Mohr U. Cancer of the pancreas induced in the Syrian golden hamster. Am J Pathol. 1974 Aug;76(2):349–358. [PMC free article] [PubMed] [Google Scholar]
- Robertson J. C., Eeles G. H. Syndrome associated with pancreatic acinar cell carcinoma. Br Med J. 1970 Jun 20;2(5711):708–709. doi: 10.1136/bmj.2.5711.708. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rowlatt U., Roe F. J. Epithelial tumors of the rat pancreas. J Natl Cancer Inst. 1967 Jul;39(1):17–32. [PubMed] [Google Scholar]
- Terrasse J., Moinade S., De la Guillaumie B., Bourdeix G., Ducroiset J. D. Cyto-stéatonécrosis et cancer du pancréas. (A propos d'un cas) Ann Med Interne (Paris) 1970 Nov;121(11):935–940. [PubMed] [Google Scholar]
- Wynder E. L. An epidemiological evaluation of the causes of cancer of the pancreas. Cancer Res. 1975 Aug;35(8):2228–2233. [PubMed] [Google Scholar]