Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1981 Jun;40(3):240–244. doi: 10.1136/ard.40.3.240

Proteinuria in rheumatoid arthritis--drug-induced or amyloid?

B E Bourke, D F Woodrow, J T Scott
PMCID: PMC1000755  PMID: 6787994

Abstract

Over a 5-year period 325 patients with rheumatoid arthritis received treatment with gold (162) or D-penicillamine (163). Thirty-eight (11.7%) developed proteinuria, which persisted in 10 patients; renal biopsies in these 10 patients revealed 6 cases of amyloid disease. These 6 cases illustrate the importance of investigation of rheumatoid patients developing proteinuria even when they are receiving potentially nephrotoxic drugs.

Full text

PDF
244

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARAPAKIS G., TRIBE C. R. AMYLOIDOSIS IN RHEUMATOID ARTHRITIS INVESTIGATED BY MEANS OF RECTAL BIOPSY. Ann Rheum Dis. 1963 Jul;22:256–262. doi: 10.1136/ard.22.4.256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bacon P. A., Tribe C. R., Mackenzie J. C., Verrier-Jones J., Cumming R. H., Amer B. Penicillamine nephropathy in rheumatoid arthritis. A clinical, pathological and immunological study. Q J Med. 1976 Oct;45(180):661–684. [PubMed] [Google Scholar]
  3. Huskisson E. C., Hart F. D. Penicillamine in the treatment of rheumatoid arthritis. Ann Rheum Dis. 1972 Sep;31(5):402–404. doi: 10.1136/ard.31.5.402. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. MISSEN G. A., TAYLOR J. D. Amyloidosis in rheumatoid arthritis. J Pathol Bacteriol. 1956 Jan;71(1):179–192. doi: 10.1002/path.1700710124. [DOI] [PubMed] [Google Scholar]
  5. PARKINS R. A., BYWATERS E. G. Regression of amyloidosis secondary to rheumatoid arthritis. Br Med J. 1959 Feb 28;1(5121):536–540. doi: 10.1136/bmj.1.5121.536. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Rainford D. J., Woodrow D. F., Sloper J. C., de Wardener H. E., Griffiths I. Post meningococcal acute glomerular nephritis. Clin Nephrol. 1978 Jun;9(6):249–253. [PubMed] [Google Scholar]
  7. Stockman A., Richter D., Barraclough D., Muirden K. D., Macdonald I., Kincaid-Smith P. Difficulties in the use of D-penicillamine in the treatment of rheumatoid arthritis. Aust N Z J Med. 1979 Oct;9(5):495–503. doi: 10.1111/j.1445-5994.1979.tb03384.x. [DOI] [PubMed] [Google Scholar]
  8. Westermark P., Stenkvist B. A new method for the diagnosis of systemic amyloidosis. Arch Intern Med. 1973 Oct;132(4):522–523. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES