Abstract
Bizarre behaviour disturbances in four patients occurring during incomplete recovery from herpes simplex encephalitis are described. Some aspects of their behaviour were similar to that originally described by Klüver and Bucy in monkeys following bilateral temporal lobectomy. Previous reports of behavioural disturbances in man after herpes simplex encephalitis are reviewed and attention drawn to the aggressive and disruptive behaviour that is often seen. With the reduced mortality in herpes simplex encephalitis in recent years it is possible that behaviour disturbances such as those described here will be seen more frequently.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aronson S. M., Aronson B. E. Clinical neuropathological conference. Pick's disease. Dis Nerv Syst. 1973 Feb;34(2):124–130. [PubMed] [Google Scholar]
- Bagshaw M. H., Mackworth N. H., Pribram K. H. The effect of resections of the inferotemporal cortex or the amygdala on visual orienting and habituation. Neuropsychologia. 1972 Jul;10(2):153–162. doi: 10.1016/0028-3932(72)90054-1. [DOI] [PubMed] [Google Scholar]
- Bear D. M. Temporal lobe epilepsy--a syndrome of sensory-limbic hyperconnection. Cortex. 1979 Sep;15(3):357–384. doi: 10.1016/s0010-9452(79)80064-7. [DOI] [PubMed] [Google Scholar]
- Brindley G. S., Janota I. Observations on cortical blindness and on vascular lesions that cause loss of recent memory. J Neurol Neurosurg Psychiatry. 1975 May;38(5):459–464. doi: 10.1136/jnnp.38.5.459. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cummings J. L., Duchen L. W. Kluver-Bucy syndrome in Pick disease: clinical and pathologic correlations. Neurology. 1981 Nov;31(11):1415–1422. doi: 10.1212/wnl.31.11.1415. [DOI] [PubMed] [Google Scholar]
- DRACHMAN D. A., ADAMS R. D. Herpes simplex and acute inclusion-body encephalitis. Arch Neurol. 1962 Jul;7:45–63. doi: 10.1001/archneur.1962.04210010051005. [DOI] [PubMed] [Google Scholar]
- Davis J. M., Davis K. R., Kleinman G. M., Kirchner H. S., Taveras J. M. Computed tomography of herpes simplex encephalitis, with clinicopathological correlation. Radiology. 1978 Nov;129(2):409–417. doi: 10.1148/129.2.409. [DOI] [PubMed] [Google Scholar]
- Davis L. E., Johnson R. T. An explanation for the localization of herpes simplex encephalitis? Ann Neurol. 1979 Jan;5(1):2–5. doi: 10.1002/ana.410050103. [DOI] [PubMed] [Google Scholar]
- DeJong R. N., Itabashi H. H., Olson J. R. Memory loss due to hippocampal lesions. Report of a case. Arch Neurol. 1969 Apr;20(4):339–348. doi: 10.1001/archneur.1969.00480100015001. [DOI] [PubMed] [Google Scholar]
- Dinn J. J. Distribution of herpes simplex virus in acute necrotising encephalitis. J Pathol. 1979 Nov;129(3):135–138. doi: 10.1002/path.1711290305. [DOI] [PubMed] [Google Scholar]
- Friedman H. M., Allen N. Chronic effects of complete limbic lobe destruction in man. Neurology. 1969 Jul;19(7):679–690. doi: 10.1212/wnl.19.7.679. [DOI] [PubMed] [Google Scholar]
- GLEES P., GRIFFITH H. B. Bilateral destruction of the hippocampus (cornu ammonis) in a case of dementia. Monatsschr Psychiatr Neurol. 1952 Apr-May;123(4-5):193–204. doi: 10.1159/000140010. [DOI] [PubMed] [Google Scholar]
- GREEN J. R., DUISBERG R. E. H., McGRATH W. B. Focal epilepsy of psychomotor type; a preliminary report of observations on effect of surgical therapy. J Neurosurg. 1951 Mar;8(2):157–172. doi: 10.3171/jns.1951.8.2.0157. [DOI] [PubMed] [Google Scholar]
- Gascon G. G., Gilles F. Limbic dementia. J Neurol Neurosurg Psychiatry. 1973 Jun;36(3):421–430. doi: 10.1136/jnnp.36.3.421. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Geschwind N. Disconnexion syndromes in animals and man. I. Brain. 1965 Jun;88(2):237–294. doi: 10.1093/brain/88.2.237. [DOI] [PubMed] [Google Scholar]
- HARA T., OKADA M. [A CASE OF ACUTE NECROTIZING ENCEPHALITIS. LESIONS IN THE LIMBIC AREAS AND KLUEVER-BUCY'S SYNDROME]. Seishin Shinkeigaku Zasshi. 1963 Aug;65:715–725. [PubMed] [Google Scholar]
- Hall P. Subacute viral encephalitis amnesia. Lancet. 1965 Nov 20;2(7421):1077–1077. doi: 10.1016/s0140-6736(65)90611-2. [DOI] [PubMed] [Google Scholar]
- Hierons R., Janota I., Corsellis J. A. The late effects of necrotizing encephalitis of the temporal lobes and limbic areas: a clinico-pathological study of 10 cases. Psychol Med. 1978 Feb;8(1):21–42. doi: 10.1017/s0033291700006607. [DOI] [PubMed] [Google Scholar]
- Horel J. A., Keating E. G., Misantone L. J. Partial Klüver-Bucy syndrome produced by destroying temporal neocortex or amygdala. Brain Res. 1975 Aug 29;94(2):347–359. doi: 10.1016/0006-8993(75)90067-0. [DOI] [PubMed] [Google Scholar]
- Marlowe W. B., Mancall E. L., Thomas J. J. Complete Klüver-Bucy syndrome in man. Cortex. 1975 Mar;11(1):53–59. doi: 10.1016/s0010-9452(75)80020-7. [DOI] [PubMed] [Google Scholar]
- POOL J. L. The visceral brain of man. J Neurosurg. 1954 Jan;11(1):45–63. doi: 10.3171/jns.1954.11.1.0045. [DOI] [PubMed] [Google Scholar]
- Pilleri G. The Klüver-Bucy Syndrome in man. A clinico-anatomical contribution to the function of the medial temporal lobe structures. Psychiatr Neurol (Basel) 1966;152(2):65–103. [PubMed] [Google Scholar]
- Pilleri G. The Klüver-Bucy Syndrome in man. A clinico-anatomical contribution to the function of the medial temporal lobe structures. Psychiatr Neurol (Basel) 1966;152(2):65–103. [PubMed] [Google Scholar]
- ROSE F. C., SYMONDS C. P. Persistent memory defect following encephalitis. Brain. 1960;83:195–212. doi: 10.1093/brain/83.2.195. [DOI] [PubMed] [Google Scholar]
- SCOVILLE W. B., MILNER B. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry. 1957 Feb;20(1):11–21. doi: 10.1136/jnnp.20.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shoji H., Teramoto H., Satowa S., Satowa H., Narita Y. Partial Klüver-Bucy Syndrome following probably herpes simplex encephalitis. J Neurol. 1979 Sep;221(3):163–167. doi: 10.1007/BF00313047. [DOI] [PubMed] [Google Scholar]
- Siegel A., Flynn J. P. Differential effects of electrical stimulation and lesions of the hippocampus and adjacent regions upon attack behavior in cats. Brain Res. 1968 Feb;7(2):252–267. doi: 10.1016/0006-8993(68)90102-9. [DOI] [PubMed] [Google Scholar]
- Taylor A., Warrington E. K. Visual agnosia: a single case report. Cortex. 1971 Jun;7(2):152–161. doi: 10.1016/s0010-9452(71)80011-4. [DOI] [PubMed] [Google Scholar]
- Trillet M., Schott B., Michel D., Barbizet J., Duizabo P. Syndrome de type Kluver et Bucy et amnésie de fixation consécutisfs à une encéphalite aiguë. J Med Lyon. 1969 Jun 5;50(166):939–passim. [PubMed] [Google Scholar]
- VICTOR M., ANGEVINE J. B., Jr, MANCALL E. L., FISHER C. M. [Memory loss with lesions of hippocampal formation. Report of a case with some remarks on the anatomical basis of memory]. Arch Neurol. 1961 Sep;5:244–263. doi: 10.1001/archneur.1961.00450150010002. [DOI] [PubMed] [Google Scholar]
- Wallack E. Selective limbic deficits after encephalitis. South Med J. 1976 May;69(5):669–671. doi: 10.1097/00007611-197605000-00052. [DOI] [PubMed] [Google Scholar]
- Whitley R. J., Soong S. J., Hirsch M. S., Karchmer A. W., Dolin R., Galasso G., Dunnick J. K., Alford C. A. Herpes simplex encephalitis: vidarabine therapy and diagnostic problems. N Engl J Med. 1981 Feb 5;304(6):313–318. doi: 10.1056/NEJM198102053040602. [DOI] [PubMed] [Google Scholar]