Skip to main content
PMC home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1985 Jan;69(1):7–14. doi: 10.1136/bjo.69.1.7

Histiocytosis X: an ophthalmological review.

A T Moore, J Pritchard, D S Taylor
PMCID: PMC1040513  PMID: 3871158

Abstract

Of 76 children with histiocytosis X 18 had orbital involvement, and four developed additional neuro-ophthalmic complications. No instance of intraocular involvement was detected. Among those patients with ophthalmic involvement the main problems were bilateral or unilateral proptosis, ptosis, papilloedema, optic atrophy, and seventh nerve palsy. Only one patient developed a severe visual defect. Management of the ophthalmological complications depends not only on the extent of the orbital disease but also on the degree of systemic involvement. Overall management by a paediatric oncologist is mandatory.

Full text

PDF
10

Images in this article

9Image
on p.9
9Image
on p.9
10Image
on p.10
10Image
on p.10
11Image
on p.11
11Image
on p.11

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON B., MARGOLIS G., LYNN W. S. Ocular lesions related to disturbances in fat metabolism. Am J Ophthalmol. 1958 Apr;45(4 Pt 2):23–41. doi: 10.1016/0002-9394(58)90219-8. [DOI] [PubMed] [Google Scholar]
  2. Baghdassarian S. A., Shammas H. F. Eosinophilic granuloma of orbit. Ann Ophthalmol. 1977 Oct;9(10):1247–1251. [PubMed] [Google Scholar]
  3. Broadbent V., Pritchard J., Davies E. G., Levinsky R. J., Heaf D., Atherton D. J., Pincott J. R., Tucker S. Spontaneous remission of multi-system histiocytosis X. Lancet. 1984 Feb 4;1(8371):253–254. doi: 10.1016/s0140-6736(84)90127-2. [DOI] [PubMed] [Google Scholar]
  4. Cohen M., Zornoza J., Cangir A., Murray J. A., Wallace S. Direct injection of methylprednisolone sodium succinate in the treatment of solitary eosinophilic granuloma of bone: a report of 9 cases. Radiology. 1980 Aug;136(2):289–293. doi: 10.1148/radiology.136.2.7403498. [DOI] [PubMed] [Google Scholar]
  5. Davies E. G., Levinsky R. J., Butler M., Broadbent V., Pritchard J., Chessells J. Thymic hormone therapy for histiocytosis X? N Engl J Med. 1983 Aug 25;309(8):493–494. [PubMed] [Google Scholar]
  6. Enriquez P., Dahlin D. C., Hayles A. B., Henderson E. D. Histiocytosis X: a clinical study. Mayo Clin Proc. 1967 Feb;42(2):88–99. [PubMed] [Google Scholar]
  7. Epstein D. L., Grant W. M. Secondary open-angle glaucoma in histiocytosis X. Am J Ophthalmol. 1977 Sep;84(3):332–336. doi: 10.1016/0002-9394(77)90674-2. [DOI] [PubMed] [Google Scholar]
  8. FEINBERG S. B., LANGER L. O. ROENTGEN FINDINGS OF INCREASED INTRACRANIAL PRESSURE AND COMMUNICATING HYDROCEPHALUS AS INSIDIOUS MANIFESTATIONS OF CHRONIC HISTIOCYTOSIS-X. Am J Roentgenol Radium Ther Nucl Med. 1965 Sep;95:41–47. doi: 10.2214/ajr.95.1.41. [DOI] [PubMed] [Google Scholar]
  9. Foucar E., Rosai J., Dorfman R. F. The ophthalmologic manifestations of sinus histiocytosis with massive lymphadenopathy. Am J Ophthalmol. 1979 Mar;87(3):354–367. doi: 10.1016/0002-9394(79)90077-1. [DOI] [PubMed] [Google Scholar]
  10. Friendly D. S., Font R. L., Rao N. A. Orbital involvement in 'sinus' histiocytosis. A report of four cases. Arch Ophthalmol. 1977 Nov;95(11):2006–2011. doi: 10.1001/archopht.1977.04450110100011. [DOI] [PubMed] [Google Scholar]
  11. Gaynes P. M., Cohen G. S. Juvenile xanthogranuloma of the orbit. Am J Ophthalmol. 1967 Apr;63(4):755–757. doi: 10.1016/0002-9394(67)91301-3. [DOI] [PubMed] [Google Scholar]
  12. Heath P. The Ocular Features of a Case of Acute Reticuloendotheliosis (Letterer-Siwe Type). Trans Am Ophthalmol Soc. 1959;57:290–302. [PMC free article] [PubMed] [Google Scholar]
  13. Kepes J. J., Kepes M. Predominantly cerebral forms of histiocytosis-X. A reappraisal of "Gagel's hypothalamic granuloma", "granuloma infiltrans of the hypothalamus" and "Ayala's disease" with a report of four cases. Acta Neuropathol. 1969;14(2):77–98. doi: 10.1007/BF00686345. [DOI] [PubMed] [Google Scholar]
  14. Lahav M., Albert D. M. Unusual ocular involvement in acute disseminated histiocytosis X. Arch Ophthalmol. 1974 Jun;91(6):455–458. doi: 10.1001/archopht.1974.03900060469008. [DOI] [PubMed] [Google Scholar]
  15. Lahey E. Histiocytosis x--an analysis of prognostic factors. J Pediatr. 1975 Aug;87(2):184–189. doi: 10.1016/s0022-3476(75)80576-2. [DOI] [PubMed] [Google Scholar]
  16. Lichtenstein L., Jeffe H. L. Eosinophilic granuloma of bone: With report of a case. Am J Pathol. 1940 Sep;16(5):595–604.3. [PMC free article] [PubMed] [Google Scholar]
  17. Lucaya J. Histiocytosis X. Am J Dis Child. 1971 Apr;121(4):289–295. doi: 10.1001/archpedi.1971.02100150063005. [DOI] [PubMed] [Google Scholar]
  18. MacCarty C. S., Brown D. N. Orbital tumors in children. Clin Neurosurg. 1964;11:76–93. doi: 10.1093/neurosurgery/11.cn_suppl_1.76. [DOI] [PubMed] [Google Scholar]
  19. Mittelman D., Apple D. J., Goldberg M. F. Ocular involvement in Letterer-Siwe disease. Am J Ophthalmol. 1973 Feb;75(2):261–265. doi: 10.1016/0002-9394(73)91022-2. [DOI] [PubMed] [Google Scholar]
  20. Mortada A. Nonlipoid and lipoid reticulo-endotheliosis of orbital bones. Am J Ophthalmol. 1966 Mar;61(3):558–561. doi: 10.1016/0002-9394(66)91069-5. [DOI] [PubMed] [Google Scholar]
  21. Mozziconacci P., Offret G., Forest A., Attal C., Girard F., Hayem F., Pham Huu Trung Histiocytose "X" avec lésions oculaires. Etude anatomique. Ann Pediatr (Paris) 1966 May 2;13(5):348–355. [PubMed] [Google Scholar]
  22. NIRANKARI M. S., SINGH M., MANCHANDA S. S., CHITKARA N. L., MAUDGAL M. C. Eosinophilic granuloma of the orbit. AMA Arch Ophthalmol. 1957 Dec;58(6):857–861. doi: 10.1001/archopht.1957.00940010879007. [DOI] [PubMed] [Google Scholar]
  23. Newton W. A., Jr, Hamoudi A. B. Histiocytosis: a histologic classification with clinical correlation. Perspect Pediatr Pathol. 1973;1:251–283. [PubMed] [Google Scholar]
  24. Osband M. E., Lipton J. M., Lavin P., Levey R., Vawter G., Greenberger J. S., McCaffrey R. P., Parkman R. Histiocytosis-X. N Engl J Med. 1981 Jan 15;304(3):146–153. doi: 10.1056/NEJM198101153040304. [DOI] [PubMed] [Google Scholar]
  25. Pritchard J. Histiocytosis X: natural history and management in childhood. Clin Exp Dermatol. 1979 Dec;4(4):421–433. doi: 10.1111/j.1365-2230.1979.tb01637.x. [DOI] [PubMed] [Google Scholar]
  26. Risdall R. J., Dehner L. P., Duray P., Kobrinsky N., Robison L., Nesbit M. E., Jr Histiocytosis X (Langerhans' cell histiocytosis). Prognostic role of histopathology. Arch Pathol Lab Med. 1983 Feb;107(2):59–63. [PubMed] [Google Scholar]
  27. Rupp R. H., Holloman K. R. Histiocytosis X affecting the uveal tract. Arch Ophthalmol. 1970 Oct;84(4):468–470. doi: 10.1001/archopht.1970.00990040470012. [DOI] [PubMed] [Google Scholar]
  28. STRAATSMA B. R. Eosinophilic granuloma of bone. Trans Am Acad Ophthalmol Otolaryngol. 1958 Nov-Dec;62(6):771–776. [PubMed] [Google Scholar]
  29. Sims D. G. Histiocytosis X; follow-up of 43 cases. Arch Dis Child. 1977 Jun;52(6):433–440. doi: 10.1136/adc.52.6.433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Smith D. G., Nesbit M. E., Jr, D'Angio G. J., Levitt S. H. Histiocytosis X: role of radiation therapy in management with special reference to dose levels employed. Radiology. 1973 Feb;106(2):419–422. doi: 10.1148/106.2.419. [DOI] [PubMed] [Google Scholar]
  31. Takahashi M., Martel W., Oberman H. A. The variable roentgenographic appearance of idiopathic histiocytosis. Clin Radiol. 1966 Jan;17(1):48–53. doi: 10.1016/s0009-9260(66)80121-6. [DOI] [PubMed] [Google Scholar]
  32. Templeton A. C. Orbital tumours in African children. Br J Ophthalmol. 1971 Apr;55(4):254–261. doi: 10.1136/bjo.55.4.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Thomas J. A., Janossy G., Chilosi M., Pritchard J., Pincott J. R. Combined immunological and histochemical analysis of skin and lymph node lesions in histiocytosis X. J Clin Pathol. 1982 Mar;35(3):327–337. doi: 10.1136/jcp.35.3.327. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES