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. 1986 Sep;70(9):662–667. doi: 10.1136/bjo.70.9.662

Ocular histopathology of acrodermatitis enteropathica.

J D Cameron, C J McClain
PMCID: PMC1040795  PMID: 3756122

Abstract

Acrodermatitis enteropathica is the clinical expression of congenital zinc deficiency and is now treated with supplemental zinc. This report details the ocular histopathology of a child who died before efficacious treatment was available. The findings include corneal epithelial thinning and loss of polarity, anterior corneal scarring and loss of Bowman's membrane, cataract formation, ciliary body atrophy, retinal degeneration, RPE depigmentation, and optic atrophy.

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Selected References

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  1. Abbasi A. A., Prasad A. S., Ortega J., Congco E., Oberleas D. Gonadal function abnormalities in sickle cell anemia. Studies in adult male patients. Ann Intern Med. 1976 Nov;85(5):601–605. doi: 10.7326/0003-4819-85-5-601. [DOI] [PubMed] [Google Scholar]
  2. Acrodermatitis enteropathica--hereditary zinc deficiency. Nutr Rev. 1975 Nov;33(11):327–329. doi: 10.1111/j.1753-4887.1975.tb05198.x. [DOI] [PubMed] [Google Scholar]
  3. Allen J. I., Kay N. E., McClain C. J. Severe zinc deficiency in humans: association with a reversible T-lymphocyte dysfunction. Ann Intern Med. 1981 Aug;95(2):154–157. doi: 10.7326/0003-4819-95-2-154. [DOI] [PubMed] [Google Scholar]
  4. Bates J., McClain C. J. The effect of severe zinc deficiency on serum levels of albumin, transferrin, and prealbumin in man. Am J Clin Nutr. 1981 Sep;34(9):1655–1660. doi: 10.1093/ajcn/34.9.1655. [DOI] [PubMed] [Google Scholar]
  5. Henkin R. I., Schechter P. J., Hoye R., Mattern C. F. Idiopathic hypogeusia with dysgeusia, hyposmia, and dysosmia. A new syndrome. JAMA. 1971 Jul 26;217(4):434–440. [PubMed] [Google Scholar]
  6. Hsu J. M., Anthony W. L., Buchanan P. J. Zinc deficiency and incorporation of 14C-labeled methionine into tissue proteins in rats. J Nutr. 1969 Dec;99(4):425–432. doi: 10.1093/jn/99.4.425. [DOI] [PubMed] [Google Scholar]
  7. Latimer J. S., McClain C. J., Sharp H. L. Clinical zinc deficiency during zinc-supplemented parenteral nutrition. J Pediatr. 1980 Sep;97(3):434–437. doi: 10.1016/s0022-3476(80)80198-3. [DOI] [PubMed] [Google Scholar]
  8. Lei K. Y., Abbasi A., Prasad A. S. Function of pituitary-gonadal axis in zinc-deficient rats. Am J Physiol. 1976 Jun;230(6):1730–1732. doi: 10.1152/ajplegacy.1976.230.6.1730. [DOI] [PubMed] [Google Scholar]
  9. Leopold I. H. Zinc deficiency and visual impairment? Am J Ophthalmol. 1978 Jun;85(6):871–875. doi: 10.1016/s0002-9394(14)78122-x. [DOI] [PubMed] [Google Scholar]
  10. Leure-duPree A. E. Electron-opaque inclusions in the rat retinal pigment epithelium after treatment with chelators of zinc. Invest Ophthalmol Vis Sci. 1981 Jul;21(1 Pt 1):1–9. [PubMed] [Google Scholar]
  11. Matta C. S., Felker G. V., Ide C. H. Eye manifestations in acrodermatitis enteropathica. Arch Ophthalmol. 1975 Feb;93(2):140–142. doi: 10.1001/archopht.1975.01010020146012. [DOI] [PubMed] [Google Scholar]
  12. McClain C. J., Soutor C., Steele N., Levine A. S., Silvis S. E. Severe zinc deficiency presenting with acrodermatitis during hyperalimentation: diagnosis, pathogenesis, and treatment. J Clin Gastroenterol. 1980 Jun;2(2):125–131. doi: 10.1097/00004836-198006000-00004. [DOI] [PubMed] [Google Scholar]
  13. McClain C. J. Trace metal abnormalities in adults during hyperalimentation. JPEN J Parenter Enteral Nutr. 1981 Sep-Oct;5(5):424–429. doi: 10.1177/0148607181005005424. [DOI] [PubMed] [Google Scholar]
  14. McClain C. J., Van Thiel D. H., Parker S., Badzin L. K., Gilbert H. Alterations in zinc, vitamin A, and retinol-binding protein in chronic alcoholics: a possible mechanism for night blindness and hypogonadism. Alcohol Clin Exp Res. 1979 Apr;3(2):135–141. doi: 10.1111/j.1530-0277.1979.tb05287.x. [DOI] [PubMed] [Google Scholar]
  15. McClain C., Soutor C., Zieve L. Zinc deficiency: a complication of Crohn's disease. Gastroenterology. 1980 Feb;78(2):272–279. [PubMed] [Google Scholar]
  16. Morrison S. A., Russell R. M., Carney E. A., Oaks E. V. Zinc deficiency: a cause of abnormal dark adaptation in cirrhotics. Am J Clin Nutr. 1978 Feb;31(2):276–281. doi: 10.1093/ajcn/31.2.276. [DOI] [PubMed] [Google Scholar]
  17. Moynahan E. J., Barnes P. M. Zinc deficiency and a synthetic diet for lactose intolerance. Lancet. 1973 Mar 24;1(7804):676–677. doi: 10.1016/s0140-6736(73)92253-8. [DOI] [PubMed] [Google Scholar]
  18. Racz P., Kovacs B., Varga L., Ujlaki E., Zombai E., Karbuczky S. Bilateral cataract in acrodermatitis enteropathica. J Pediatr Ophthalmol Strabismus. 1979 May-Jun;16(3):180–182. doi: 10.3928/0191-3913-19790501-11. [DOI] [PubMed] [Google Scholar]
  19. Solomons N. W., Russell R. M. The interaction of vitamin A and zinc: implications for human nutrition. Am J Clin Nutr. 1980 Sep;33(9):2031–2040. doi: 10.1093/ajcn/33.9.2031. [DOI] [PubMed] [Google Scholar]
  20. Sunderman F. W., Jr Current status of zinc deficiency in the pathogenesis of neurological, dermatological and musculoskeletal disorders. Ann Clin Lab Sci. 1975 Mar-Apr;5(2):132–145. [PubMed] [Google Scholar]
  21. WIRSCHING L., Jr Eye symptoms in Acromdermatitis enteropathica. A description of a brother and sister, with corneal changes. Acta Ophthalmol (Copenh) 1962;40:567–574. doi: 10.1111/j.1755-3768.1962.tb07832.x. [DOI] [PubMed] [Google Scholar]
  22. Warkany J., Petering H. G. Congenital malformations of the central nervous system in rats produced by maternal zinc deficiency. Teratology. 1972 Jun;5(3):319–334. doi: 10.1002/tera.1420050307. [DOI] [PubMed] [Google Scholar]
  23. Warshawsky R. S., Hill C. W., Doughman D. J., Harris J. E. Acrodermatitis enteropathica. Corneal involvement with histochemical and electron micrographic studies. Arch Ophthalmol. 1975 Mar;93(3):194–197. doi: 10.1001/archopht.1975.01010020202007. [DOI] [PubMed] [Google Scholar]
  24. Weismann K., Wadskov S., Mikkelsen H. I., Knudsen L., Christensen K. C., Storgaard L. Acquired zinc deficiency dermatosis in man. Arch Dermatol. 1978 Oct;114(10):1509–1511. [PubMed] [Google Scholar]

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