Abstract
Myo-inositol, especially in combination with arginine, enhances streptomycin production. Compounds which show structural relationship with myo-inositol are ineffective.
Myo-inositol decreases the incorporation of C14-glucose into streptomycin, particularly into streptidine. This effect suggests that myo-inositol is a precursor of the streptidine ring.
Methionine stimulates antibiotic production in a synthetic medium but proves to be unfavorable in a complex medium.
The γ- and δ-isomers of hexachlorocyclohexane inhibit streptomycin formation.
The formation of streptomycin by washed mycelium was studied. Essentially the same results were here obtained as with growing cultures.
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