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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 1994 Sep;57(9):1070–1072. doi: 10.1136/jnnp.57.9.1070

Benign form of multiple sclerosis: MRI evidence for less frequent and less inflammatory disease activity.

D Kidd 1, A J Thompson 1, B E Kendall 1, D H Miller 1, W I McDonald 1
PMCID: PMC1073129  PMID: 8089671

Abstract

Data from two serial studies comparing the MRI activity of two groups of 11 patients, one with early relapsing-remitting (mean disease duration 3.5 years), the other benign (mean disease duration 22 years) multiple sclerosis are presented. Those with benign disease developed fewer new or enlarging lesions, and such lesions that occurred had a lower incidence of gadolinium enhancement, a marker of inflammation. These results, when considered in conjunction with other published studies, suggest that both the frequency of new lesions and the amount of inflammation within them influence the development of disability in multiple sclerosis.

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Selected References

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  1. Bonduelle M., Bouygues P., Degos C. F., Gauthier C. Les formes bénignes de la sclérose en plaques. Révaluation. Rev Neurol (Paris) 1979 Oct;135(8-9):593–604. [PubMed] [Google Scholar]
  2. Confavreux C., Aimard G., Devic M. Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients. Brain. 1980 Jun;103(2):281–300. doi: 10.1093/brain/103.2.281. [DOI] [PubMed] [Google Scholar]
  3. England J. D., Gamboni F., Levinson S. R., Finger T. E. Changed distribution of sodium channels along demyelinated axons. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6777–6780. doi: 10.1073/pnas.87.17.6777. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Johnson E. S., Ludwin S. K. The demonstration of recurrent demyelination and remyelination of axons in the central nervous system. Acta Neuropathol. 1981;53(2):93–98. doi: 10.1007/BF00689988. [DOI] [PubMed] [Google Scholar]
  5. Katz D., Taubenberger J. K., Cannella B., McFarlin D. E., Raine C. S., McFarland H. F. Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis. Ann Neurol. 1993 Nov;34(5):661–669. doi: 10.1002/ana.410340507. [DOI] [PubMed] [Google Scholar]
  6. Kidd D., Thorpe J. W., Thompson A. J., Kendall B. E., Moseley I. F., MacManus D. G., McDonald W. I., Miller D. H. Spinal cord MRI using multi-array coils and fast spin echo. II. Findings in multiple sclerosis. Neurology. 1993 Dec;43(12):2632–2637. doi: 10.1212/wnl.43.12.2632. [DOI] [PubMed] [Google Scholar]
  7. Kurtzke J. F., Beebe G. W., Nagler B., Kurland L. T., Auth T. L. Studies on the natural history of multiple sclerosis--8. Early prognostic features of the later course of the illness. J Chronic Dis. 1977 Dec;30(12):819–830. doi: 10.1016/0021-9681(77)90010-8. [DOI] [PubMed] [Google Scholar]
  8. Ludwin S. K. Chronic demyelination inhibits remyelination in the central nervous system. An analysis of contributing factors. Lab Invest. 1980 Oct;43(4):382–387. [PubMed] [Google Scholar]
  9. MCALPINE D. The benign form of multiple sclerosis. A study based on 241 cases seen within three years of onset and followed up until the tenth year or more of the disease. Brain. 1961 Jun;84:186–203. doi: 10.1093/brain/84.2.186. [DOI] [PubMed] [Google Scholar]
  10. McDonald W. I., Miller D. H., Barnes D. The pathological evolution of multiple sclerosis. Neuropathol Appl Neurobiol. 1992 Aug;18(4):319–334. doi: 10.1111/j.1365-2990.1992.tb00794.x. [DOI] [PubMed] [Google Scholar]
  11. Miller D. H., Hornabrook R. W., Purdie G. The natural history of multiple sclerosis: a regional study with some longitudinal data. J Neurol Neurosurg Psychiatry. 1992 May;55(5):341–346. doi: 10.1136/jnnp.55.5.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Morrissey S. P., Miller D. H., Kendall B. E., Kingsley D. P., Kelly M. A., Francis D. A., MacManus D. G., McDonald W. I. The significance of brain magnetic resonance imaging abnormalities at presentation with clinically isolated syndromes suggestive of multiple sclerosis. A 5-year follow-up study. Brain. 1993 Feb;116(Pt 1):135–146. doi: 10.1093/brain/116.1.135. [DOI] [PubMed] [Google Scholar]
  13. Poser C. M., Paty D. W., Scheinberg L., McDonald W. I., Davis F. A., Ebers G. C., Johnson K. P., Sibley W. A., Silberberg D. H., Tourtellotte W. W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol. 1983 Mar;13(3):227–231. doi: 10.1002/ana.410130302. [DOI] [PubMed] [Google Scholar]
  14. Prineas J. W., Barnard R. O., Revesz T., Kwon E. E., Sharer L., Cho E. S. Multiple sclerosis. Pathology of recurrent lesions. Brain. 1993 Jun;116(Pt 3):681–693. doi: 10.1093/brain/116.3.681. [DOI] [PubMed] [Google Scholar]
  15. Thompson A. J., Hutchinson M., Brazil J., Feighery C., Martin E. A. A clinical and laboratory study of benign multiple sclerosis. Q J Med. 1986 Jan;58(225):69–80. [PubMed] [Google Scholar]
  16. Thompson A. J., Kermode A. G., MacManus D. G., Kendall B. E., Kingsley D. P., Moseley I. F., McDonald W. I. Patterns of disease activity in multiple sclerosis: clinical and magnetic resonance imaging study. BMJ. 1990 Mar 10;300(6725):631–634. doi: 10.1136/bmj.300.6725.631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Thompson A. J., Kermode A. G., Wicks D., MacManus D. G., Kendall B. E., Kingsley D. P., McDonald W. I. Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann Neurol. 1991 Jan;29(1):53–62. doi: 10.1002/ana.410290111. [DOI] [PubMed] [Google Scholar]
  18. Thompson A. J., Miller D., Youl B., MacManus D., Moore S., Kingsley D., Kendall B., Feinstein A., McDonald W. I. Serial gadolinium-enhanced MRI in relapsing/remitting multiple sclerosis of varying disease duration. Neurology. 1992 Jan;42(1):60–63. doi: 10.1212/wnl.42.1.60. [DOI] [PubMed] [Google Scholar]
  19. Waxman S. G., Ritchie J. M. Organization of ion channels in the myelinated nerve fiber. Science. 1985 Jun 28;228(4707):1502–1507. doi: 10.1126/science.2409596. [DOI] [PubMed] [Google Scholar]

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