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. 1988 Dec;41(12):1277–1280. doi: 10.1136/jcp.41.12.1277

Clinicopathological importance of primary dysplasia of bladder.

R J Zuk 1, H S Rogers 1, J E Martin 1, S I Baithun 1
PMCID: PMC1141760  PMID: 3225329

Abstract

A retrospective study of 15 patients with primary dysplasia of bladder urothelium was performed in an attempt to clarify some of the clinical and histopathological features. The lesion occurs predominantly in middle aged men who present with irritative bladder symptoms with or without haematuria and show no evidence of bacteriological urinary tract infection. Appearances at cystoscopy are non-specific. Thirteen patients showed no progression to carcinoma in situ after a long period of follow up, but primary dysplasia cannot be regarded as an entirely innocuous condition as the remaining two patients did develop carcinoma in situ. The grade of dysplasia on presentation bears no relation to the final outcome. Regular cytological analysis of urine seems to be the best means of follow up, and more active treatment does not seem to be justified.

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Selected References

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  1. EISENBERG R. B., ROTH R. B., SCHWEINSBERG M. H. Bladder tumors and associated proliferative mucosal lesions. J Urol. 1960 Oct;84:544–550. doi: 10.1016/S0022-5347(17)65589-7. [DOI] [PubMed] [Google Scholar]
  2. Farrow G. M., Utz D. C., Rife C. C. Morphological and clinical observations of patients with early bladder cancer treated with total cystectomy. Cancer Res. 1976 Jul;36(7 Pt 2):2495–2501. [PubMed] [Google Scholar]
  3. Fox C. H. Biologic behavior of dysplasia and carcinoma in situ. Am J Obstet Gynecol. 1967 Dec 1;99(7):960–974. doi: 10.1016/0002-9378(67)90251-7. [DOI] [PubMed] [Google Scholar]
  4. Highman W. J. Flat in situ carcinoma of the bladder: cytological examination of urine in diagnosis, follow up, and assessment of response to chemotherapy. J Clin Pathol. 1988 May;41(5):540–546. doi: 10.1136/jcp.41.5.540. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Jenkins B. J., England H. R., Fowler C. G., Tiptaft R. C., Badenoch D. F., Paris A. M., Oliver R. T., Blandy J. P. Chemotherapy for carcinoma in situ of the bladder. Br J Urol. 1988 Apr;61(4):326–329. doi: 10.1111/j.1464-410x.1988.tb13967.x. [DOI] [PubMed] [Google Scholar]
  6. Kakizoe T., Matumoto K., Nishio Y., Ohtani M., Kishi K. Significance of carcinoma in situ and dysplasia in association with bladder cancer. J Urol. 1985 Mar;133(3):395–398. doi: 10.1016/s0022-5347(17)48994-4. [DOI] [PubMed] [Google Scholar]
  7. Koss L. G., Tiamson E. M., Robbins M. A. Mapping cancerous and precancerous bladder changes. A study of the urothelium in ten surgically removed bladders. JAMA. 1974 Jan 21;227(3):281–286. [PubMed] [Google Scholar]
  8. MELICOW M. M., HOLLOWELL J. W. Intra-urothelial cancer: carcinoma in situ, Bowen's disease of the urinary system: discussion of thirty cases. J Urol. 1952 Oct;68(4):763–772. doi: 10.1016/S0022-5347(17)68279-X. [DOI] [PubMed] [Google Scholar]
  9. Murphy W. M., Soloway M. S. Developing carcinoma (dysplasia) of the urinary bladder. Pathol Annu. 1982;17(Pt 1):197–217. [PubMed] [Google Scholar]
  10. Murphy W. M., Soloway M. S. Urothelial dysplasia. J Urol. 1982 May;127(5):849–854. doi: 10.1016/s0022-5347(17)54105-1. [DOI] [PubMed] [Google Scholar]
  11. Nagy G. K., Frable W. J., Murphy W. M. Classification of premalignant urothelial abnormalities. A Delphi study of the National Bladder Cancer Collaborative Group A. Pathol Annu. 1982;17(Pt 1):219–233. [PubMed] [Google Scholar]
  12. PETERSEN O. Spontaneous course of cervical precancerous conditions. Am J Obstet Gynecol. 1956 Nov;72(5):1063–1071. doi: 10.1016/0002-9378(56)90072-2. [DOI] [PubMed] [Google Scholar]
  13. Schade R. O., Swinney J. Pre-cancerous changes in bladder epithelium. Lancet. 1968 Nov 2;2(7575):943–946. doi: 10.1016/s0140-6736(68)91169-0. [DOI] [PubMed] [Google Scholar]
  14. Soloway M. S., Murphy W., Rao M. K., Cox C. Serial multiple-site biopsies in patients with bladder cancer. J Urol. 1978 Jul;120(1):57–59. doi: 10.1016/s0022-5347(17)57037-8. [DOI] [PubMed] [Google Scholar]
  15. Utz D. C., Farrow G. M., Rife C. C., Segura J. W., Zincke H. Carcinoma in situ of the bladder. Cancer. 1980 Apr 15;45(7 Suppl):1842–1848. [PubMed] [Google Scholar]
  16. Zincke H., Utz D. C., Farrow G. M. Review of Mayo Clinic experience with carcinoma in situ. Urology. 1985 Oct;26(4 Suppl):39–46. [PubMed] [Google Scholar]

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