Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1987 Mar 1;242(2):441–445. doi: 10.1042/bj2420441

Zymosan-induced release of inositol phosphates at resting cytosolic Ca2+ concentrations in macrophages.

J Moscat, C Herrero, P Garcia-Barreno, A M Municio
PMCID: PMC1147724  PMID: 3109391

Abstract

Hydrolysis of polyphosphoinositides by phosphodiesterase has been demonstrated to be involved in the control of cytosolic Ca2+ concentrations. The stimulation of Ca2+ ionophores of the release of inositol phosphates in macrophages, and other cells, together with the Ca2+ requirements for zymosan-induced phospholipase C activation, make unclear the relationship between Ca2+ mobilization and polyphosphoinositide hydrolysis. The results in the present paper strongly suggest that, for zymosan-induced phospholipase C activation, a previous increase in cytosolic Ca2+ is not a required event. These results also show that zymosan-activated release of inositol phosphates may be mediated by a guanine-nucleotide-binding protein.

Full text

PDF
441

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aderem A. A., Scott W. A., Cohn Z. A. Evidence for sequential signals in the induction of the arachidonic acid cascade in macrophages. J Exp Med. 1986 Jan 1;163(1):139–154. doi: 10.1084/jem.163.1.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bell R. L., Kennerly D. A., Stanford N., Majerus P. W. Diglyceride lipase: a pathway for arachidonate release from human platelets. Proc Natl Acad Sci U S A. 1979 Jul;76(7):3238–3241. doi: 10.1073/pnas.76.7.3238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Berridge M. J., Dawson R. M., Downes C. P., Heslop J. P., Irvine R. F. Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J. 1983 May 15;212(2):473–482. doi: 10.1042/bj2120473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Berridge M. J., Irvine R. F. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature. 1984 Nov 22;312(5992):315–321. doi: 10.1038/312315a0. [DOI] [PubMed] [Google Scholar]
  5. Berridge M. J. Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. Biochem J. 1983 Jun 15;212(3):849–858. doi: 10.1042/bj2120849. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bocckino S. B., Blackmore P. F., Exton J. H. Stimulation of 1,2-diacylglycerol accumulation in hepatocytes by vasopressin, epinephrine, and angiotensin II. J Biol Chem. 1985 Nov 15;260(26):14201–14207. [PubMed] [Google Scholar]
  7. COHN Z. A., BENSON B. THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY. J Exp Med. 1965 Jan 1;121:153–170. doi: 10.1084/jem.121.1.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cockcroft S., Baldwin J. M., Allan D. The Ca2+-activated polyphosphoinositide phosphodiesterase of human and rabbit neutrophil membranes. Biochem J. 1984 Jul 15;221(2):477–482. doi: 10.1042/bj2210477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Cockcroft S. Contrasting roles for receptor-stimulated inositol lipid metabolism in secretory cells. Biochem Soc Trans. 1984 Dec;12(6):966–968. doi: 10.1042/bst0120966. [DOI] [PubMed] [Google Scholar]
  10. Creutz C. E., Dowling L. G., Kyger E. M., Franson R. C. Phosphatidylinositol-specific phospholipase C activity of chromaffin granule-binding proteins. J Biol Chem. 1985 Jun 25;260(12):7171–7173. [PubMed] [Google Scholar]
  11. Downes C. P., Michell R. H. The polyphosphoinositide phosphodiesterase of erythrocyte membranes. Biochem J. 1981 Jul 15;198(1):133–140. doi: 10.1042/bj1980133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Emilsson A., Sundler R. Differential activation of phosphatidylinositol deacylation and a pathway via diphosphoinositide in macrophages responding to zymosan and ionophore A23187. J Biol Chem. 1984 Mar 10;259(5):3111–3116. [PubMed] [Google Scholar]
  13. Friedel R. O., Brown J. D., Durell J. The enzymic hydrolysis of phosphatidyl inositol by guinea pig brain: Sub-cellular distribution and hydrolysis products. J Neurochem. 1969 Mar;16(3):371–378. doi: 10.1111/j.1471-4159.1969.tb10376.x. [DOI] [PubMed] [Google Scholar]
  14. Griendling K. K., Rittenhouse S. E., Brock T. A., Ekstein L. S., Gimbrone M. A., Jr, Alexander R. W. Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells. J Biol Chem. 1986 May 5;261(13):5901–5906. [PubMed] [Google Scholar]
  15. Haslam R. J., Davidson M. M. Receptor-induced diacylglycerol formation in permeabilized platelets; possible role for a GTP-binding protein. J Recept Res. 1984;4(1-6):605–629. doi: 10.3109/10799898409042576. [DOI] [PubMed] [Google Scholar]
  16. Irvine R. F., Letcher A. J., Dawson R. M. Phosphatidylinositol-4,5-bisphosphate phosphodiesterase and phosphomonoesterase activities of rat brain. Some properties and possible control mechanisms. Biochem J. 1984 Feb 15;218(1):177–185. doi: 10.1042/bj2180177. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Litosch I., Fain J. N. 5-Methyltryptamine stimulates phospholipase C-mediated breakdown of exogenous phosphoinositides by blowfly salivary gland membranes. J Biol Chem. 1985 Dec 25;260(30):16052–16055. [PubMed] [Google Scholar]
  18. Merritt J. E., Taylor C. W., Rubin R. P., Putney J. W., Jr Evidence suggesting that a novel guanine nucleotide regulatory protein couples receptors to phospholipase C in exocrine pancreas. Biochem J. 1986 Jun 1;236(2):337–343. doi: 10.1042/bj2360337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Michell R. H., Lapetina E. G. Production of cyclic inositol phosphate in stimulated tissues. Nat New Biol. 1972 Dec 27;240(104):258–260. doi: 10.1038/newbio240258a0. [DOI] [PubMed] [Google Scholar]
  20. Moscat G., Moreno F., Iglesias S., Garcia-Barreno P., Municio A. M. Ionophore A23187 induces a refractory state in thrombin-activated release of inositol phosphates. Biochem J. 1986 Sep 15;238(3):709–714. doi: 10.1042/bj2380709. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Moscat J., Aracil M., Diez E., Balsinde J., Garcia Barreno P., Municio A. M. Intracellular Ca2+ requirements for zymosan-stimulated phosphoinositide hydrolysis in mouse peritoneal macrophages. Biochem Biophys Res Commun. 1986 Jan 14;134(1):367–371. doi: 10.1016/0006-291x(86)90572-3. [DOI] [PubMed] [Google Scholar]
  22. Moscat J., Herrero C., Garcia-Barreno P., Municio A. M. Phospholipase C-diglyceride lipase is a major pathway for arachidonic acid release in macrophages. Biochem Biophys Res Commun. 1986 Nov 26;141(1):367–373. doi: 10.1016/s0006-291x(86)80378-3. [DOI] [PubMed] [Google Scholar]
  23. Nishizuka Y. Turnover of inositol phospholipids and signal transduction. Science. 1984 Sep 21;225(4668):1365–1370. doi: 10.1126/science.6147898. [DOI] [PubMed] [Google Scholar]
  24. RAAFLAUB J. Applications of metal buffers and metal indicators in biochemistry. Methods Biochem Anal. 1956;3:301–325. doi: 10.1002/9780470110195.ch10. [DOI] [PubMed] [Google Scholar]
  25. Sasaki T., Hasegawa-Sasaki H. Breakdown of phosphatidylinositol 4,5-bisphosphate in a T-cell leukaemia line stimulated by phytohaemagglutinin is not dependent on Ca2+ mobilization. Biochem J. 1985 May 1;227(3):971–979. doi: 10.1042/bj2270971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Schacht J. Purification of polyphosphoinositides by chromatography on immobilized neomycin. J Lipid Res. 1978 Nov;19(8):1063–1067. [PubMed] [Google Scholar]
  27. Smith C. D., Lane B. C., Kusaka I., Verghese M. W., Snyderman R. Chemoattractant receptor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate in human polymorphonuclear leukocyte membranes. Requirement for a guanine nucleotide regulatory protein. J Biol Chem. 1985 May 25;260(10):5875–5878. [PubMed] [Google Scholar]
  28. Vicentini L. M., Ambrosini A., Di Virgilio F., Pozzan T., Meldolesi J. Muscarinic receptor-induced phosphoinositide hydrolysis at resting cytosolic Ca2+ concentration in PC12 cells. J Cell Biol. 1985 Apr;100(4):1330–1333. doi: 10.1083/jcb.100.4.1330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Wolf M., LeVine H., 3rd, May W. S., Jr, Cuatrecasas P., Sahyoun N. A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters. Nature. 1985 Oct 10;317(6037):546–549. doi: 10.1038/317546a0. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES