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. 1987 Mar 1;242(2):441–445. doi: 10.1042/bj2420441

Zymosan-induced release of inositol phosphates at resting cytosolic Ca2+ concentrations in macrophages.

J Moscat, C Herrero, P Garcia-Barreno, A M Municio
PMCID: PMC1147724  PMID: 3109391

Abstract

Hydrolysis of polyphosphoinositides by phosphodiesterase has been demonstrated to be involved in the control of cytosolic Ca2+ concentrations. The stimulation of Ca2+ ionophores of the release of inositol phosphates in macrophages, and other cells, together with the Ca2+ requirements for zymosan-induced phospholipase C activation, make unclear the relationship between Ca2+ mobilization and polyphosphoinositide hydrolysis. The results in the present paper strongly suggest that, for zymosan-induced phospholipase C activation, a previous increase in cytosolic Ca2+ is not a required event. These results also show that zymosan-activated release of inositol phosphates may be mediated by a guanine-nucleotide-binding protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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