Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1987 Oct 1;247(1):113–120. doi: 10.1042/bj2470113

The derivation and interpretation of control coefficients.

B Crabtree 1, E A Newsholme 1
PMCID: PMC1148377  PMID: 3689338

Abstract

1. Equations for control coefficients are derived by using a method that generates all the control coefficients for a system in a single procedure. This requires solving fewer simultaneous equations than an equivalent method based on 'control theorems'. 2. The interpretation of control coefficients is discussed: in particular, it is shown that these functions are unsatisfactory as measures of 'control' and are perhaps best used as a means of testing control theories (models).

Full text

PDF
120

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Belforte G., Bona B., Milanese M. Advanced modeling and identification techniques for metabolic processes. Crit Rev Biomed Eng. 1984;10(4):275–316. [PubMed] [Google Scholar]
  2. Crabtree B., Newsholme E. A. A quantitative approach to metabolic control. Curr Top Cell Regul. 1985;25:21–76. doi: 10.1016/b978-0-12-152825-6.50006-0. [DOI] [PubMed] [Google Scholar]
  3. Fell D. A., Sauro H. M. Metabolic control and its analysis. Additional relationships between elasticities and control coefficients. Eur J Biochem. 1985 May 2;148(3):555–561. doi: 10.1111/j.1432-1033.1985.tb08876.x. [DOI] [PubMed] [Google Scholar]
  4. Groen A. K., Wanders R. J., Westerhoff H. V., van der Meer R., Tager J. M. Quantification of the contribution of various steps to the control of mitochondrial respiration. J Biol Chem. 1982 Mar 25;257(6):2754–2757. [PubMed] [Google Scholar]
  5. Groen A. K., van Roermund C. W., Vervoorn R. C., Tager J. M. Control of gluconeogenesis in rat liver cells. Flux control coefficients of the enzymes in the gluconeogenic pathway in the absence and presence of glucagon. Biochem J. 1986 Jul 15;237(2):379–389. doi: 10.1042/bj2370379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Heinrich R., Rapoport T. A. A linear steady-state treatment of enzymatic chains. General properties, control and effector strength. Eur J Biochem. 1974 Feb 15;42(1):89–95. doi: 10.1111/j.1432-1033.1974.tb03318.x. [DOI] [PubMed] [Google Scholar]
  7. Hofmeyr J. H., Kacser H., van der Merwe K. J. Metabolic control analysis of moiety-conserved cycles. Eur J Biochem. 1986 Mar 17;155(3):631–641. doi: 10.1111/j.1432-1033.1986.tb09534.x. [DOI] [PubMed] [Google Scholar]
  8. Kacser H., Burns J. A. The control of flux. Symp Soc Exp Biol. 1973;27:65–104. [PubMed] [Google Scholar]
  9. Kacser H. The control of enzyme systems in vivo: elasticity analysis of the steady state. Biochem Soc Trans. 1983 Jan;11(1):35–40. doi: 10.1042/bst0110035. [DOI] [PubMed] [Google Scholar]
  10. LaPorte D. C., Koshland D. E., Jr Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation. Nature. 1983 Sep 22;305(5932):286–290. doi: 10.1038/305286a0. [DOI] [PubMed] [Google Scholar]
  11. Rognstad R. Rate-limiting steps in metabolic pathways. J Biol Chem. 1979 Mar 25;254(6):1875–1878. [PubMed] [Google Scholar]
  12. Salter M., Knowles R. G., Pogson C. I. Quantification of the importance of individual steps in the control of aromatic amino acid metabolism. Biochem J. 1986 Mar 15;234(3):635–647. doi: 10.1042/bj2340635. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Srivastava D. K., Bernhard S. A. Metabolite transfer via enzyme-enzyme complexes. Science. 1986 Nov 28;234(4780):1081–1086. doi: 10.1126/science.3775377. [DOI] [PubMed] [Google Scholar]
  14. Westerhoff H. V., Groen A. K., Wanders R. J. Modern theories of metabolic control and their applications (review). Biosci Rep. 1984 Jan;4(1):1–22. doi: 10.1007/BF01120819. [DOI] [PubMed] [Google Scholar]
  15. van der Horst R. L. The frequency of different types of heart disease in South African Blacks at a cardiac referral center. Int J Cardiol. 1984 Aug;6(2):240–243. doi: 10.1016/0167-5273(84)90360-7. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES