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. 1991 Jan 1;273(Pt 1):195–198. doi: 10.1042/bj2730195

L-lactate uptake by rat liver. Effect of food deprivation and substrate availability.

A Felipe 1, X Remesar 1, M Pastor-Anglada 1
PMCID: PMC1149898  PMID: 1989581

Abstract

We have studied the role of substrate availability on net L-lactate uptake by liver of anaesthetized fed and 24 h-fasted rats. L-Lactate was infused through a mesenteric vein at infusion rates equivalent to 0, 0.125, 0.25 and 0.5 times the basal turnover rate (Rt). By these means we were able to increase L-lactate portal concentrations up to 5.5 mM, without significant changes in portal pH. In the basal state (0 Rt), a net L-lactate uptake by liver was found in 24 h-fasted animals. No net balance was observed in fed rats. Infusion of L-lactate in fed animals failed to induce a net hepatic uptake, except when L-lactate levels in portal vein were raised above 5 mM. In fasted animals, net L-lactate uptake by liver increased linearly (r = 0.99) as a function of L-lactate concentration in the portal vein, even beyond the saturation of its specific carrier. It is concluded that, first, the L-lactate carrier does not limit net L-lactate uptake, and second, that substrate availability is an important factor modulating net L-lactate uptake by liver.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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