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. 1991 Mar 1;274(Pt 2):369–374. doi: 10.1042/bj2740369

Transport in isolated rat hepatocytes of the phospho-oligosaccharide that mimics insulin action. Effects of adrenalectomy and glucocorticoid treatment.

J F Alvarez 1, J A Sánchez-Arias 1, A Guadaño 1, F Estévez 1, I Varela 1, J E Felíu 1, J M Mato 1
PMCID: PMC1150146  PMID: 2006906

Abstract

The addition to intact cells of an inositol phospho-oligosaccharide (POS), which is the polar head-group of an insulin-sensitive glycosylphosphatidylinositol, mimics and may mediate some of the biological effects of this hormone. Here we report the existence of a POS transport system in hepatocytes. This POS transport system is specific and time- and dose-dependent. Insulin-resistance caused by dexamethasone administration to rats was accompanied by a decrease in the hepatocyte POS transport system. In contrast, bilateral adrenalectomy provoked a significant increase in the transport of POS. Both the temporal uptake of POS and the regulation of this process by conditions known to modify the sensitivity to insulin suggest that this novel transport system might be involved in the insulin signalling mechanism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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