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. 1983 Nov 15;216(2):507–510. doi: 10.1042/bj2160507

The stimulation of glycogenolysis and gluconeogenesis in isolated hepatocytes by opioid peptides.

E H Allan, I C Green, M A Titheradge
PMCID: PMC1152532  PMID: 6661213

Abstract

The opioid agonists [leucine]enkephalin, [D-Ala2,D-Leu5]enkephalin and dynorphin-(1-13)-peptide, but not morphine, stimulated the conversion of [2-14C]pyruvate into glucose and glycogenolysis when added directly to isolated hepatocytes. Naloxone produced a small but significant inhibition of both the basal and stimulated rate of incorporation of label into glucose but had no effect on the total glucose output by the cells. The effects of the opioid peptides were mediated by a cyclic AMP-independent mechanism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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