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. 1983 Nov 15;216(2):507–510. doi: 10.1042/bj2160507

The stimulation of glycogenolysis and gluconeogenesis in isolated hepatocytes by opioid peptides.

E H Allan, I C Green, M A Titheradge
PMCID: PMC1152532  PMID: 6661213

Abstract

The opioid agonists [leucine]enkephalin, [D-Ala2,D-Leu5]enkephalin and dynorphin-(1-13)-peptide, but not morphine, stimulated the conversion of [2-14C]pyruvate into glucose and glycogenolysis when added directly to isolated hepatocytes. Naloxone produced a small but significant inhibition of both the basal and stimulated rate of incorporation of label into glucose but had no effect on the total glucose output by the cells. The effects of the opioid peptides were mediated by a cyclic AMP-independent mechanism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BORISON H. L., FISHBURN B. R., BHIDE N. K., McCARTHY L. E. Morphine-induced hyperglycemia in the cat. J Pharmacol Exp Ther. 1962 Nov;138:229–235. [PubMed] [Google Scholar]
  2. Chisholm A. B., Allan E. H., Titheradge M. A. Regulation of mitochondrial pyruvate carboxylation in isolated hepatocytes by acute insulin treatment. Biochem J. 1983 Aug 15;214(2):451–458. doi: 10.1042/bj2140451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dey P. K., Feldberg W. Hyperglycaemia produced by drugs with analgesic properties introduced into the cerebral ventricles of cats. Br J Pharmacol. 1975 Jun;54(2):163–170. doi: 10.1111/j.1476-5381.1975.tb06925.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Feldberg W., Gupta K. P. Morphine hyperglycaemia. J Physiol. 1974 May;238(3):487–502. doi: 10.1113/jphysiol.1974.sp010539. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Green I. C., Perrin D., Pedley K. C., Leslie R. D., Pyke D. A. Effect of enkephalins and morphine on insulin secretion from isolated rat islets. Diabetologia. 1980 Aug;19(2):158–161. doi: 10.1007/BF00421864. [DOI] [PubMed] [Google Scholar]
  6. Huidobro-Toro J. P., Way E. L. Comparative study on the effect of morphine and the opioid-like peptides in the vas deferens of rodents: species and strain differences, evidence for multiple opiate receptors. Life Sci. 1981 Mar 23;28(12):1331–1336. doi: 10.1016/0024-3205(81)90405-7. [DOI] [PubMed] [Google Scholar]
  7. Ipp E., Dobbs R., Unger R. H. Morphine and beta-endorphin influence the secretion of the endocrine pancreas. Nature. 1978 Nov 9;276(5684):190–191. doi: 10.1038/276190a0. [DOI] [PubMed] [Google Scholar]
  8. Lord J. A., Waterfield A. A., Hughes J., Kosterlitz H. W. Endogenous opioid peptides: multiple agonists and receptors. Nature. 1977 Jun 9;267(5611):495–499. doi: 10.1038/267495a0. [DOI] [PubMed] [Google Scholar]
  9. Malfroy B., Swerts J. P., Llorens C., Schwartz J. C. Regional distribution of a high-affinity enkephalin-degrading peptidase ('enkephalinase') and effects of lesions suggest localization in the vicinity of opiate receptors in brain. Neurosci Lett. 1979 Mar;11(3):329–334. doi: 10.1016/0304-3940(79)90017-x. [DOI] [PubMed] [Google Scholar]
  10. Miranda H., Huidobro F., Huidobro-Toro J. P. Evidence for morphine and morphine-like alkaloid responses resistant to naloxone blockade in the rat vas deferens. Life Sci. 1979 Apr 16;24(16):1511–1518. doi: 10.1016/0024-3205(79)90035-3. [DOI] [PubMed] [Google Scholar]
  11. Reid R. L., Yen S. S. beta-Endorphin stimulates the secretion of insulin and glucagon in humans. J Clin Endocrinol Metab. 1981 Mar;52(3):592–594. doi: 10.1210/jcem-52-3-592. [DOI] [PubMed] [Google Scholar]
  12. Shaw J. S., Miller L., Turnbull M. J., Gormley J. J., Morley J. S. Selective antagonists at the opiate delta-receptor. Life Sci. 1982 Sep 20;31(12-13):1259–1262. doi: 10.1016/0024-3205(82)90356-3. [DOI] [PubMed] [Google Scholar]
  13. Wong S. C., Yeung D. C. Effect of morphine on gluconeogenesis and ureogenesis in rat liver. Int J Biochem. 1981;13(3):323–327. doi: 10.1016/0020-711x(81)90085-9. [DOI] [PubMed] [Google Scholar]
  14. Wong S. C., Yeung Y. G., Yeung D. Effects of morphine on isoenzymes of pyruvate kinase and tyrosine aminotransferase in rat. Biochem Pharmacol. 1978 May 1;27(9):1347–1351. doi: 10.1016/0006-2952(78)90118-1. [DOI] [PubMed] [Google Scholar]

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