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. 1981 Aug 1;197(2):523–526. doi: 10.1042/bj1970523

Identification and characterization of a phospholipase C activity in resident mouse peritoneal macrophages. Inhibition of the enzyme by phenothiazines

Paul D Wightman *, Mary Ellen Dahlgren *, James C Hall †, Philip Davies *, Robert J Bonney *
PMCID: PMC1163156  PMID: 7325971

Abstract

Resident mouse peritoneal macrophages contain a phospholipase C of high activity that is specific for phosphatidylinositol. The activity has a neutral pH optimum, is Ca2+-dependent and has a maximum reaction velocity of 525nmol/h per mg of protein. Certain phenothiazines are potent inhibitors of this activity.

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Selected References

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