Abstract
A method is described for isolating cyclic [3H]GMP from platelets preincubated with [3H]guanine. Collagen increased and aspirin decreased the cyclic [3H]GMP concentration in platelets. The results are consistent with a role for cyclic GMP in the platelet release reaction.
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- Ball G., Brereton G. G., Fulwood M., Ireland D. M., Yates P. Effet of prostaglandin E1 alone and in combination with theophylline or aspirin on collagen-induced platelet aggregation and on platelet nucleotides including adenosine 3':5'-cyclic monophosphate. Biochem J. 1970 Dec;120(4):709–718. doi: 10.1042/bj1200709. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evans G., Packham M. A., Nishizawa E. E., Mustard J. F., Murphy E. A. The effect of acetylsalicyclic acid on platelet function. J Exp Med. 1968 Nov 1;128(5):877–894. doi: 10.1084/jem.128.5.877. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haslam R. J. Interactions of the pharmacological receptors of blood platelets with adenylate cyclase. Ser Haematol. 1973;6(3):333–350. [PubMed] [Google Scholar]
- Haslam R. J., Rosson G. M. Aggregation of human blood platelets by vasopressin. Am J Physiol. 1972 Oct;223(4):958–967. doi: 10.1152/ajplegacy.1972.223.4.958. [DOI] [PubMed] [Google Scholar]
- Haslam R. J., Taylor A. Effects of catecholamines on the formation of adenosine 3':5'-cyclic monophosphate in human blood platelets. Biochem J. 1971 Nov;125(1):377–379. doi: 10.1042/bj1250377. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ignarro L. J. Neutral protease release from human leukocytes regulated by neurohormones and cyclic nucleotides. Nat New Biol. 1973 Oct 3;245(144):151–154. doi: 10.1038/newbio245151a0. [DOI] [PubMed] [Google Scholar]
- KREBS H. A., HEMS R. Some reactions of adenosine and inosine phosphates in animal tissues. Biochim Biophys Acta. 1953 Sep-Oct;12(1-2):172–180. doi: 10.1016/0006-3002(53)90136-x. [DOI] [PubMed] [Google Scholar]
- Kaliner M., Orange R. P., Austen K. F. Immunological release of histamine and slow reacting substance of anaphylaxis from human lung. J Exp Med. 1972 Sep 1;136(3):556–567. doi: 10.1084/jem.136.3.556. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kuo J. F., De Renzo E. C. A comparison of the effects of lipolytic and antilipolytic agents on adenosine 3',5'-monophosphate levels in adipose cells as determined by prior labeling with adenine-8-14C. J Biol Chem. 1969 May 10;244(9):2252–2260. [PubMed] [Google Scholar]
- Mustard J. F., Packham M. A. Factors influencing platelet function: adhesion, release, and aggregation. Pharmacol Rev. 1970 Jun;22(2):97–187. [PubMed] [Google Scholar]
- Ramwell P. W., Shaw J. E. Biological significance of the prostaglandins. Recent Prog Horm Res. 1970;26:139–187. doi: 10.1016/b978-0-12-571126-5.50008-x. [DOI] [PubMed] [Google Scholar]
- Salzman E. W. Cyclic AMP and platelet function. N Engl J Med. 1972 Feb 17;286(7):358–363. doi: 10.1056/NEJM197202172860708. [DOI] [PubMed] [Google Scholar]
- Scales B. A new scintillator for liquid scintillation counting. Int J Appl Radiat Isot. 1967 Jan;18(1):1–6. doi: 10.1016/0020-708x(67)90165-2. [DOI] [PubMed] [Google Scholar]
- Shimizu H., Daly J. Formation of cyclic adenosine 3',5'-monophosphate from adenosine in brain slices. Biochim Biophys Acta. 1970 Nov 24;222(2):465–473. doi: 10.1016/0304-4165(70)90137-6. [DOI] [PubMed] [Google Scholar]
- Smith J. B., Willis A. L. Aspirin selectively inhibits prostaglandin production in human platelets. Nat New Biol. 1971 Jun 23;231(25):235–237. doi: 10.1038/newbio231235a0. [DOI] [PubMed] [Google Scholar]
- Turtle J. R., Kipnis D. M. A new assay for adenosine 3',5'-cyclic monophosphate in tissue. Biochemistry. 1967 Dec;6(12):3970–3976. doi: 10.1021/bi00864a044. [DOI] [PubMed] [Google Scholar]
- Vane J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. doi: 10.1038/newbio231232a0. [DOI] [PubMed] [Google Scholar]
- Weiss H. J., Aledort L. M. Impaired platelet-connective-tissue reaction in man after aspirin ingestion. Lancet. 1967 Sep 2;2(7514):495–497. doi: 10.1016/s0140-6736(67)91658-3. [DOI] [PubMed] [Google Scholar]
- Zucker M. B., Peterson J. Effect of acetylsalicylic acid, other nonsteroidal anti-inflammatory agents, and dipyridamole on human blood platelets. J Lab Clin Med. 1970 Jul;76(1):66–75. [PubMed] [Google Scholar]