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. 1969 Jun;113(2):377–386. doi: 10.1042/bj1130377

An aspartic acid residue at the active site of pepsin. The isolation and sequence of the heptapeptide

R S Bayliss 1, J R Knowles 1, Grith B Wybrandt 1
PMCID: PMC1184645  PMID: 4897201

Abstract

Pepsin reacts stoicheiometrically with the active-site-directed irreversible inhibitor N-diazoacetyl-l-phenylalanine methyl ester, with concomitant loss of all proteolytic and peptidolytic activity. The reagent esterifies a unique aspartic acid residue in pepsin, which is in the sequence:Ile-Val-Asp-Thr-Gly-Thr-Ser

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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