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. 1970 Mar;116(5):791–796. doi: 10.1042/bj1160791

Subunits of Tamm–Horsfall glycoprotein

F K Stevenson 1, P W Kent 1
PMCID: PMC1185500  PMID: 5441368

Abstract

1. The effect of 6m-guanidine hydrochloride on the urinary glycoprotein described by Tamm & Horsfall (1952) is to produce a homogeneous subunit of molecular weight approx. 100000. 2. Complete reduction of the disulphide bonds of this subunit does not decrease the molecular weight, suggesting that all disulphide bonds are intrachain. 3. Comparison of sedimentation and viscometric behaviour of unreduced and reduced material in 6m-guanidine hydrochloride is consistent with reduction causing an opening-up of intrachain disulphide bonds to give a more asymmetric molecule.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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