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. 1978 Dec 15;176(3):865–872. doi: 10.1042/bj1760865

Post-translational regulation of lipoprotein lipase activity in adipose tissue.

P Ashby, D P Bennett, I M Spencer, D S Robinson
PMCID: PMC1186310  PMID: 747657

Abstract

Changes in adipose-tissue lipoprotein lipase activity that are independent of protein synthesis were investigated in an incubation system in vitro. Under appropriate conditions at 25 degrees C a progressive increase in the enzyme activity occurs that is energy-dependent. Part of the enzyme is rapidly inactivated when the tissue is incubated with adrenaline or adrenaline plus theophylline. The mechanism of this inactivation appears to be distinct from, and to follow, the activation of the enzyme. A hypothesis is presented to account for the results in terms of an activation of the enzyme during obligatory post-translational processing and a catecholamine-regulated inactivation of the enzyme as an alternative to secretion from the adipocyte.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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