Abstract
1. After intraperitoneal administration, γ-hexachlorocyclohexane (Gammexane) and γ-2,3,4,5,6-pentachlorocyclohex-1-ene were converted by rats into 2,3,5- and 2,4,5-trichlorophenol, which were excreted as free phenols and as sulphuric acid and glucuronic acid conjugates. 2. Derivatives of 2,4,5-trichlorophenol and 2,4,5-trichlorophenyl glucosiduronic acid and 2,4-dichlorophenylmercapturic acid were isolated from the urine as metabolites of γ-2,3,4,5,6-pentachlorocyclohex-1-ene. 3. The phenolic metabolites of γ-hexachlorocyclohexane and γ-2,3,4,5,6-pentachlorocyclohex-1-ene isolated from urine were similar to those of 1,2,4-trichlorobenzene, which indicates that the two latter compounds are intermediates in γ-hexachlorocyclohexane metabolism in rats.
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Selected References
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