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. 1965 Aug;96(2):521–525. doi: 10.1042/bj0960521

The metabolism of γ-2,3,4,5,6-pentachlorocyclohex-1-ene and γ-hexachlorocyclohexane in rats

P L Grover 1, P Sims 1
PMCID: PMC1207069  PMID: 4158352

Abstract

1. After intraperitoneal administration, γ-hexachlorocyclohexane (Gammexane) and γ-2,3,4,5,6-pentachlorocyclohex-1-ene were converted by rats into 2,3,5- and 2,4,5-trichlorophenol, which were excreted as free phenols and as sulphuric acid and glucuronic acid conjugates. 2. Derivatives of 2,4,5-trichlorophenol and 2,4,5-trichlorophenyl glucosiduronic acid and 2,4-dichlorophenylmercapturic acid were isolated from the urine as metabolites of γ-2,3,4,5,6-pentachlorocyclohex-1-ene. 3. The phenolic metabolites of γ-hexachlorocyclohexane and γ-2,3,4,5,6-pentachlorocyclohex-1-ene isolated from urine were similar to those of 1,2,4-trichlorobenzene, which indicates that the two latter compounds are intermediates in γ-hexachlorocyclohexane metabolism in rats.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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