Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1981 Jun;315:31–41. doi: 10.1113/jphysiol.1981.sp013730

Pancreatic endocrine responses to stimulation of the peripheral ends of the vagus nerves in conscious calves.

S R Bloom, A V Edwards
PMCID: PMC1249365  PMID: 7031230

Abstract

1. The effects of stimulation of the peripheral ends of both vagus nerves below the heart (10 Hz for 10 min) were investigated in conscious calves 2-5 weeks after birth. 2. Stimulation was invariably below behavioural threshold and caused a prompt increase in the concentrations of pancreatic glucagon, insulin and pancreatic polypeptide (PP) in the arterial plasma. Each of these responses was blocked by pretreatment with atropine (0.2 mg/kg). 3. Administration of exogenous glucose by continuous I.V. infusion (ca. 0.08 mmol kg-1 min-1) greatly enhanced the release of insulin in response to vagal stimulation without significantly changing that of pancreatic glucagon or PP. 4. Vagal stimulation also caused a significant rise in the concentration of vasoactive intestinal peptide (VIP) in the intestinal lymph and this response was found to persist in the presence of atropine.

Full text

PDF
35

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adrian T. E., Bloom S. R., Bryant M. G., Polak J. M., Heitz P. H., Barnes A. J. Distribution and release of human pancreatic polypeptide. Gut. 1976 Dec;17(12):940–944. doi: 10.1136/gut.17.12.940. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Adrian T. E., Bloom S. R., Hermansen K., Iversen J. Pancreatic polypeptide, glucagon and insulin secretion from the isolated perfused canine pancreas. Diabetologia. 1978 Jun;14(6):413–417. doi: 10.1007/BF01228136. [DOI] [PubMed] [Google Scholar]
  3. Albano J. D., Ekins R. P., Maritz G., Turner R. C. A sensitive, precise radioimmunoassay of serum insulin relying on charcoal separation of bound and free hormone moieties. Acta Endocrinol (Copenh) 1972 Jul;70(3):487–509. doi: 10.1530/acta.0.0700487. [DOI] [PubMed] [Google Scholar]
  4. Assan R., Slusher N. Structure-function and structure-immunoreactivity relationships of the glucagon molecule and related synthetic peptides. Diabetes. 1972 Aug;21(8):843–855. doi: 10.2337/diab.21.8.843. [DOI] [PubMed] [Google Scholar]
  5. Barnes R. J., Bower E. A., Rink T. J. Haemodynamic responses to stimulation of the cardiac autonomic nerves in the anaesthetized cat with closed chest. J Physiol. 1980 Feb;299:55–73. doi: 10.1113/jphysiol.1980.sp013110. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Blackburn A. M., Bloom S. R., Edwards A. V. Pancreatic endocrine responses to exogenous neurotensin in the conscious calf. J Physiol. 1981 May;314:11–21. doi: 10.1113/jphysiol.1981.sp013686. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bloom S. R., Edwards A. V. Certain pharmacological characteristics of the release of pancreatic glucagon in response to stimulation of the splanchnic nerves. J Physiol. 1978 Jul;280:25–35. doi: 10.1113/jphysiol.1978.sp012370. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Bloom S. R., Edwards A. V. Effects of autonomic stimulation on the release of vasoactive intestinal peptide from the gastrointestinal tract in the calf. J Physiol. 1980 Feb;299:437–452. doi: 10.1113/jphysiol.1980.sp013135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bloom S. R., Edwards A. V., Hardy R. N. Adrenal and pancreatic endocrine responses to hypoxia and hypercapnia in the calf. J Physiol. 1977 Jul;269(1):131–154. doi: 10.1113/jphysiol.1977.sp011896. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bloom S. R., Edwards A. V., Hardy R. N., Silver M. Adrenal and pancreatic endocrine responses to hypoxia in the conscious calf. J Physiol. 1976 Oct;261(2):271–283. doi: 10.1113/jphysiol.1976.sp011558. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Bloom S. R., Edwards A. V., Hardy R. N. The role of the autonomic nervous system in the control of glucagon, insulin and pancreatic polypeptide release from the pancreas. J Physiol. 1978 Jul;280:9–23. doi: 10.1113/jphysiol.1978.sp012369. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Bloom S. R., Edwards A. V., Hardy R. N. The role of the autonomic nervous system in the control of pancreatic endocrine responses to milk ingestion in the calf. J Physiol. 1978 Jul;280:37–53. doi: 10.1113/jphysiol.1978.sp012371. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Bloom S. R., Edwards A. V., Järhult J. The effect of somatostatin on pancreatic endocrine responses mediated via the parasympathetic innervation in the conscious calf. J Physiol. 1980 Nov;308:29–38. doi: 10.1113/jphysiol.1980.sp013459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Bloom S. R., Edwards A. V. Pancreatic endocrine responses to stimulation of the peripheral ends of the splanchnic nerves in the conscious adrenalectomized calf. J Physiol. 1980 Nov;308:39–48. doi: 10.1113/jphysiol.1980.sp013460. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Bloom S. R., Edwards A. V. The role of the parasympathetic system in the control of insulin release in the conscious calf. J Physiol. 1981 May;314:37–46. doi: 10.1113/jphysiol.1981.sp013688. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Bloom S. R., Edwards A. V., Vaughan N. J. The role of the autonomic innervation in the control of glucagon release during hypoglycaemia in the calf. J Physiol. 1974 Feb;236(3):611–623. doi: 10.1113/jphysiol.1974.sp010455. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Bloom S. R., Edwards A. V., Vaughan N. J. The role of the sympathetic innervation in the control of plasma glucagon concentration in the calf. J Physiol. 1973 Sep;233(2):457–466. doi: 10.1113/jphysiol.1973.sp010317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Daniel P. M., Henderson J. R. The effect of vagal stimulation on plasma insulin and glucose levels in the baboon. J Physiol. 1967 Sep;192(2):317–327. doi: 10.1113/jphysiol.1967.sp008302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Edwards A. V., Birchman P. M., Mitchell S. J., Bloom S. R. Changes in the concentration of vasoactive intestinal peptide in intestinal lymph in response to vagal stimulation in the calf. Experientia. 1978 Sep 15;34(9):1186–1187. doi: 10.1007/BF01922948. [DOI] [PubMed] [Google Scholar]
  20. Edwards A. V., Furness P. N., Helle K. B. Adrenal medullary responses to stimulation of the splanchnic nerve in the conscious calf. J Physiol. 1980 Nov;308:15–27. doi: 10.1113/jphysiol.1980.sp013458. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Fahrenkrug J., Galbo H., Holst J. J., Schaffalitzky de Muckadell O. B. Influence of the autonomic nervous system on the release of vasoactive intestinal polypeptide from the porcine gastrointestinal tract. J Physiol. 1978 Jul;280:405–422. doi: 10.1113/jphysiol.1978.sp012391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Fahrenkrug J., Haglund U., Jodal M., Lundgren O., Olbe L., de Muckadell O. B. Nervous release of vasoactive intestinal polypeptide in the gastrointestinal tract of cats: possible physiological implications. J Physiol. 1978 Nov;284:291–305. doi: 10.1113/jphysiol.1978.sp012541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Frohman L. A., Ezdinli E. Z., Javid R. Effect of vagotomy and vagal stimulation on insulin secretion. Diabetes. 1967 Jul;16(7):443–448. doi: 10.2337/diab.16.7.443. [DOI] [PubMed] [Google Scholar]
  24. Kaneto A., Kosaka K., Nakao K. Effects of stimulation of the vagus nerve on insulin secretion. Endocrinology. 1967 Mar;80(3):530–536. doi: 10.1210/endo-80-3-530. [DOI] [PubMed] [Google Scholar]
  25. Larsson L. I., Fahrenkrug J., Holst J. J., Schaffalitzky de Muckadell O. B. Innervation of the pancreas by vasoactive intestinal polypeptide (VIP) immunoreactive nerves. Life Sci. 1978 Mar;22(9):773–780. doi: 10.1016/0024-3205(78)90246-1. [DOI] [PubMed] [Google Scholar]
  26. Larsson L. I. Innervation of the pancreas by substance P, enkephalin, vasoactive intestinal polypeptide and gastrin/CCK immunoractive nerves. J Histochem Cytochem. 1979 Sep;27(9):1283–1284. doi: 10.1177/27.9.479572. [DOI] [PubMed] [Google Scholar]
  27. Mitchell S. J., Bloom S. R. Measurement of fasting and postprandial plasma VIP in man. Gut. 1978 Nov;19(11):1043–1048. doi: 10.1136/gut.19.11.1043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Rehfeld J. F., Larsson L. I., Goltermann N. R., Schwartz T. W., Holst J. J., Jensen S. L., Morley J. S. Neural regulation of pancreatic hormone secretion by the C-terminal tetrapeptide of CCK. Nature. 1980 Mar 6;284(5751):33–38. doi: 10.1038/284033a0. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES