Abstract
1. The inhibitory effect of salicylate, in concentrations ranging from 0·1 to 20mm, on the incorporation of radioactivity from l-[U-14C]leucine into the protein of isolated rat diaphragm muscle and of cell-free systems from rat liver was studied. 2. The lowest salicylate concentrations producing significant inhibitions of amino acid incorporation were as follows: isolated rat diaphragm, 0·1mm; rat-liver mitochondrial–microsomal system, 0·1mm; rat-liver microsomal system, 0·3mm. 3. Salicylate concentrations of 2·5mm and above were found to inhibit creatine-kinase activity in vitro.
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