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. 1976 Jul;184(1):97–102. doi: 10.1097/00000658-197607000-00016

Suppression of gastrin release and gastric secretion by gastric inhibitory polypeptide (GIP) and vasoactive intestinal polypeptide (VIP).

H V Villar, H R Fender, P L Rayford, S R Bloom, N I Ramus, J C Thompson
PMCID: PMC1344314  PMID: 938120

Abstract

Five dogs prepared with Heidenhain pouches received infusions of saline, GIP and VIP before and after a standard meat meal. Blood samples were obtained under basal conditions and at subsequent intervals for measurement of gastrin, insulin, GIP and VIP by radioimmunoassay. GIP and VIP infusions had no effect on basal levels of gastrin. GIP and VIP (in common with secretin and glucagon) were found to suppress food-stimulated release of gastrin and gastrin-stimulated acid secretion from the Heidenhain pouch. Insulin levels were significantly elevated during GIP and VIP infusions. Food released GIP (and perhaps VIP.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Becker H. D., Reeder D. D., Thompson J. C. Effect of glucagon on circulating gastrin. Gastroenterology. 1973 Jul;65(1):28–35. [PubMed] [Google Scholar]
  2. Bloom S. R., Polak J. M., Pearse A. G. Vasoactive intestinal peptide and watery-diarrhoea syndrome. Lancet. 1973 Jul 7;2(7819):14–16. doi: 10.1016/s0140-6736(73)91947-8. [DOI] [PubMed] [Google Scholar]
  3. Brown J. C., Dryburgh J. R. A gastric inhibitory polypeptide. II. The complete amino acid sequence. Can J Biochem. 1971 Aug;49(8):867–872. doi: 10.1139/o71-122. [DOI] [PubMed] [Google Scholar]
  4. Brown J. C., Pederson R. A. A multiparameter study on the action of preparations containing cholecystokinin-pancreozymin. Scand J Gastroenterol. 1970;5(6):537–541. [PubMed] [Google Scholar]
  5. Bunchman H. H., 2nd, Reeder D. D., Thompson J. C. Effect of secretin on the serum gastrin response to a meal in man and in dog. Surg Forum. 1971;22:303–304. [PubMed] [Google Scholar]
  6. DREILING D. A., JANOWITZ H. D. The effect of glucagon on gastric secretion in man. Gastroenterology. 1959 May;36(5):580–581. [PubMed] [Google Scholar]
  7. GREENLEE H. B., LONGHI E. H., GUERRERO J. D., NELSEN T. S., EL-BEDRI A. L., DRAGSTEDT L. R. Inhibitory effect of pancreatic secretin on gastric secretion. Am J Physiol. 1957 Sep;190(3):396–402. doi: 10.1152/ajplegacy.1957.190.3.396. [DOI] [PubMed] [Google Scholar]
  8. Jackson B. M., Reeder D. D., Thompson J. C. Dynamic characteristics of gastrin release. Am J Surg. 1972 Feb;123(2):137–142. doi: 10.1016/0002-9610(72)90323-6. [DOI] [PubMed] [Google Scholar]
  9. Kerins C., Said S. I. Hyperglycemic and glycogenolytic effects of vasoactive intestinal polypeptide. Proc Soc Exp Biol Med. 1973 Mar;142(3):1014–1017. doi: 10.3181/00379727-142-37165. [DOI] [PubMed] [Google Scholar]
  10. Kuzio M., Dryburgh J. R., Malloy K. M., Brown J. C. Radioimmunoassay for gastric inhibitory polypeptide. Gastroenterology. 1974 Mar;66(3):357–364. [PubMed] [Google Scholar]
  11. Melrose A. G. Effect of Glucagon on Gastric Secretion in Man. Gut. 1960 Jun;1(2):142–145. doi: 10.1136/gut.1.2.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Orci L., Pictet R., Forssmann W. G., Renold A. E., Rouiller C. Structural evidence for glucagon producing cells in the intestinal mucosa of the rat. Diabetologia. 1968 Jan;4(1):56–67. doi: 10.1007/BF01241034. [DOI] [PubMed] [Google Scholar]
  13. Pederson R. A., Brown J. C. Inhibition of histamine-, pentagastrin-, and insulin-stimulated canine gastric secretion by pure "gastric inhibitory polypeptide". Gastroenterology. 1972 Mar;62(3):393–400. [PubMed] [Google Scholar]
  14. ROBINSON R. M., HARRIS K., HLAD C. J., EISEMAN B. Effect of glucagon on gastric secretion. Proc Soc Exp Biol Med. 1957 Nov;96(2):518–520. doi: 10.3181/00379727-96-23525. [DOI] [PubMed] [Google Scholar]
  15. Rayford P. L., Reeder D. D., Thompson J. C. Interlaboratory reproducibility of gastrin measurements by radioimmunoassay. J Lab Clin Med. 1975 Sep;86(3):521–527. [PubMed] [Google Scholar]
  16. Said S. I., Mutt V. Polypeptide with broad biological activity: isolation from small intestine. Science. 1970 Sep 18;169(3951):1217–1218. doi: 10.1126/science.169.3951.1217. [DOI] [PubMed] [Google Scholar]
  17. Said S. I., Mutt V. Potent peripheral and splanchnic vasodilator peptide from normal gut. Nature. 1970 Feb 28;225(5235):863–864. doi: 10.1038/225863a0. [DOI] [PubMed] [Google Scholar]
  18. Thompson J. C., Reeder D. D., Bunchman H. H., Becker H. D., Brandt E. N., Jr Effect of secretin on circulating gastrin. Ann Surg. 1972 Sep;176(3):384–393. doi: 10.1097/00000658-197209000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Thompson J. C., Reeder D. D., Villar H. V., Fender H. R. Natural history and experience with diagnosis and treatment of the Zollinger-Ellison syndrome. Surg Gynecol Obstet. 1975 May;140(5):721–739. [PubMed] [Google Scholar]

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