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. 1982 Jul;196(1):38–42. doi: 10.1097/00000658-198207000-00009

Twenty-four- and 48-hour Canine Liver Preservation by Simple Hypothermia with Prostacyclin

Morito Monden, Joseph G Fortner
PMCID: PMC1352494  PMID: 7046655

Abstract

Canine livers were preserved by simple hypothermic storage using modified Sacks' solution and prostacyclin. Orthotopic liver transplantation was then carried out. Five of six and three of five livers preserved for 24 and 48 hours, respectively, were able to sustain life for more than five days.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abouna G. M., Koo C. G., Howanitz L. F., Ancarani E., Porter K. A. Successful orthotopic liver transplantation after preservation by simple hypothermia. Transplant Proc. 1971 Mar;3(1):650–653. [PubMed] [Google Scholar]
  2. Araki H., Lefer A. M. Cytoprotective actions of prostacyclin during hypoxia in the isolated perfused cat liver. Am J Physiol. 1980 Feb;238(2):H176–H181. doi: 10.1152/ajpheart.1980.238.2.H176. [DOI] [PubMed] [Google Scholar]
  3. Benichou J., Halgrimson C. G., Weil R., 3rd, Koep L. J., Starzl T. E. Canine and human liver preservation for 6 to 18 hr by cold infusion. Transplantation. 1977 Dec;24(6):407–411. doi: 10.1097/00007890-197712000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Calne R. Y., Dunn D. C., Herbertson B. M., Gordon E. M., Bitter-Suermann H., Robson A. J., Macdonald A. S., Davis D. R., Smith D. P., Reitter F. H. Liver preservation by single passage hypothermic "squirt" perfusion. Br Med J. 1972 Oct 21;4(5833):142–144. doi: 10.1136/bmj.4.5833.142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dusting G. J., Moncada S., Vane J. R. Prostacyclin (PGX) is the endogenous metabolite responsible for relaxation of coronary arteries induced by arachindonic acid. Prostaglandins. 1977 Jan;13(1):3–15. doi: 10.1016/0090-6980(77)90037-5. [DOI] [PubMed] [Google Scholar]
  6. Fortner J. G., Kim D. K., Shiu M. H., Yeh S. D., Howland W. S., Beattie E. J., Jr Heterotopic (auxiliary) liver transplantation in man. Transplant Proc. 1977 Mar;9(1):217–221. [PubMed] [Google Scholar]
  7. Lefer A. M., Ogletree M. L., Smith J. B., Silver M. J., Nicolaou K. C., Barnette W. E., Gasic G. P. Prostacyclin: a potentially valuable agent for preserving myocardial tissue in acute myocardial ischemia. Science. 1978 Apr 7;200(4337):52–54. doi: 10.1126/science.345441. [DOI] [PubMed] [Google Scholar]
  8. Moncada S., Gryglewski R., Bunting S., Vane J. R. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature. 1976 Oct 21;263(5579):663–665. doi: 10.1038/263663a0. [DOI] [PubMed] [Google Scholar]
  9. Monden M., Barters R. H., Fortner J. G. A simple method of orthotopic liver transplantation in dogs. Ann Surg. 1982 Jan;195(1):110–113. doi: 10.1097/00000658-198201001-00016. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Petrie C. R., Woods J. E. Successful 24-hour preservation of the canine liver. Arch Surg. 1973 Sep;107(3):461–464. doi: 10.1001/archsurg.1973.01350210091023. [DOI] [PubMed] [Google Scholar]
  11. Sacks S. A., Petritsch P. H., Kaufman J. J. Canine kidney preservation using a new perfusate. Lancet. 1973 May 12;1(7811):1024–1028. doi: 10.1016/s0140-6736(73)90665-x. [DOI] [PubMed] [Google Scholar]
  12. Slapak M., Wigmore R. A., MacLean L. D. Twenty-four hour liver preservation by the use of continuous pulsatile perfusion and hyperbaric oxygen. Transplantation. 1967 Jul;5(4 Suppl):1154–1158. doi: 10.1097/00007890-196707001-00052. [DOI] [PubMed] [Google Scholar]
  13. Spilg H., Uys C. J., Hickman R., Saunders S. J., Terblanche J. Successful liver transplantation after storage for 6-8 hours, using a simple hypothermic immersion technique. Transplantation. 1971 May;11(5):457–460. doi: 10.1097/00007890-197105000-00004. [DOI] [PubMed] [Google Scholar]
  14. Toledo-Pereyra L. H., Chee M., Lillehei R. C., Condie R. M. Liver preservation by cold storage with hyperosmolar solutions for twenty-four hours. Cryobiology. 1979 Feb;16(1):43–49. doi: 10.1016/0011-2240(79)90008-7. [DOI] [PubMed] [Google Scholar]
  15. Toledo-Pereyra L. H., Simmons R. L., Najarian J. S. Factors determining successful liver preservation for transplantation. Ann Surg. 1975 Mar;181(3):289–298. doi: 10.1097/00000658-197503000-00008. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Toledo-Pereyra L. H. Twenty-four-hour liver preservation by hypothermic intermittent perfusion. Transplantation. 1979 Apr;27(4):291–293. [PubMed] [Google Scholar]
  17. Turner M. D., Alican F. Successful 20-hour storage of the canine liver by continuous hypothermic perfusion. Cryobiology. 1970 Jan-Feb;6(4):293–301. doi: 10.1016/s0011-2240(70)80083-9. [DOI] [PubMed] [Google Scholar]
  18. Wall W. J., Calne R. Y., Herbertson B. M., Baker P. G., Smith D. P., Underwood J., Kostakis A., Williams R. Simple hypothermic preservation for transporting human livers long distances for transplantation. Report of 12 cases. Transplantation. 1977 Mar;23(3):210–216. doi: 10.1097/00007890-197703000-00002. [DOI] [PubMed] [Google Scholar]
  19. Whittaker N., Bunting S., Salmon J., Moncada S., Vane J. R., Johnson R. A., Morton D. R., Kinner J. H., Gorman R. R., McGuire J. C. The chemical structure of prostaglandin X (prostacyclin). Prostaglandins. 1976 Dec;12(6):915–928. doi: 10.1016/0090-6980(76)90126-x. [DOI] [PubMed] [Google Scholar]

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