Skip to main content
PMC home page
Annals of Surgery logoLink to Annals of Surgery
. 1972 Sep;176(3):370–383. doi: 10.1097/00000658-197209000-00013

Genetic aspects of the Z-E syndrome: prospective studies in two kindred; antral gastrin cell hyperplasia.

S R Friesen, R N Schimke, A G Pearse
PMCID: PMC1355410  PMID: 4342160

Full text

PDF
371

Images in this article

375Fig. 2.
on p.375
376Fig. 3.
on p.376
376Fig. 4.
on p.376
377Fig. 5.
on p.377
377Fig. 6.
on p.377
378Fig. 7.
on p.378
378Fig. 8.
on p.378
379Fig. 9.
on p.379

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALLARD H. S., FAME B., HARTSOCK R. J. FAMILIAL MULTIPLE ENDOCRINE ADENOMA-PEPTIC ULCER COMPLEX. Medicine (Baltimore) 1964 Jul;43:481–516. [PubMed] [Google Scholar]
  2. CODE C. F., HALLENBECK G. A., SUMMERSKILL W. H. Extraction of a gastric secretagogue from primary and metastatic islet cell tumors in three cases of Zollinger-Ellison syndrome. J Surg Res. 1962 Mar;2:136–140. doi: 10.1016/s0022-4804(62)80009-2. [DOI] [PubMed] [Google Scholar]
  3. Creutzfeldt W., Arnold R., Creutzfeldt C., Feurle G., Ketterer H. Gastrin and G-cells in the antral mucosa of patients with pernicious anaemia, acromegaly and hyperparathyroidism and in a Zollinger-Ellison tumour of the pancreas. Eur J Clin Invest. 1971 Sep;1(6):461–479. doi: 10.1111/j.1365-2362.1971.tb00558.x. [DOI] [PubMed] [Google Scholar]
  4. Dutta P., Wallace M. R., Wrong O. M., Taylor S., Welbourn R. B. Familial multiple endocrine adenopathy (primary hyperparathyroidism and Zollinger-Ellison syndrome) in two siblings. Proc R Soc Med. 1968 Jul;61(7):658–660. [PMC free article] [PubMed] [Google Scholar]
  5. ELLISON E. H., WILSON S. D. THE ZOLLINGER-ELLISON SYNDROME: RE-APPRAISAL AND EVALUATION OF 260 REGISTERED CASES. Ann Surg. 1964 Sep;160:512–530. doi: 10.1097/00000658-196409000-00013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FREISEN S. R., TRACY H. J., GREGORY R. A. Mechanism of the gastric hypersecretion in the Zollinger-Ellison syndrome: successful extraction of gastrin-like activity from metastases and primary pancreatico-duodenal islet cell carcinoma. Ann Surg. 1962 Feb;155:167–174. doi: 10.1097/00000658-196200000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Friesen S. R. A gastric factor in the pathogenesis of the Zollinger-Ellison syndrome. Ann Surg. 1968 Sep;168(3):483–501. doi: 10.1097/00000658-196809000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Friesen S. R., Bolinger R. E., Pearse A. G., McGuigan J. E. Serum gastrin levels in malignant Zollinger-Ellison Syndrome after total gastrectomy and hypophysectomy. Ann Surg. 1970 Sep;172(3):504–521. doi: 10.1097/00000658-197009000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Friesen S. R. Effect of total gastrectomy on the Zollinger-Ellison tumor: observations by second-look procedures. Surgery. 1967 Oct;62(4):609–613. [PubMed] [Google Scholar]
  10. Hallenbeck G. A. The Zollinger-Ellison syndrome. Gastroenterology. 1968 Mar;54(3):426–433. [PubMed] [Google Scholar]
  11. Johnson G. J., Summerskill W. H., Anderson V. E., Keating F. R., Jr Clinical and genetic investigation of a large kindred with multiple endocrine adenomatosis. N Engl J Med. 1967 Dec 28;277(26):1379–1385. doi: 10.1056/NEJM196712282772601. [DOI] [PubMed] [Google Scholar]
  12. Lomský R., Langer F., Vortel V. Immunohistochemical demonstration of gastrin in mammalian islets of Langerhans. Nature. 1969 Aug 9;223(5206):618–619. doi: 10.1038/223618a0. [DOI] [PubMed] [Google Scholar]
  13. MOLDAWER M. P., NARDI G. L., RAKER J. W. Concomitance of multiple adenomas of the parathyroids and pancreatic islets with tumor of the pituitary: a syndrome with a familial incidence. Am J Med Sci. 1954 Aug;228(2):190–206. doi: 10.1097/00000441-195408000-00008. [DOI] [PubMed] [Google Scholar]
  14. MOLDAWER M. Multiple endocrine tumors and Zollinger-Ellison syndrome in families: one or two syndromes? A report of two new families. Metabolism. 1962 Jan;11:153–156. [PubMed] [Google Scholar]
  15. McGuigan J. E. Gastric mucosal intracellular localization of gastrin by immunofluorescence. Gastroenterology. 1968 Sep;55(3):315–327. [PubMed] [Google Scholar]
  16. McGuigan J. E., Greider M. H. Correlative immuncchemical and light microscopic studies of the gastrin cell of the antral mucosa. Gastroenterology. 1971 Feb;60(2):223–236. [PubMed] [Google Scholar]
  17. McGuigan J. E., Trudeau W. L. Immunochemical measurement of elevated levels of gastrin in the serum of patients with pancreatic tumors of the Zollinger-Ellison variety. N Engl J Med. 1968 Jun 13;278(24):1308–1313. doi: 10.1056/NEJM196806132782402. [DOI] [PubMed] [Google Scholar]
  18. Pearse A. G., Bussolati G. Immunofluorescence studies on the distribution of gastrin cells in different clinical states. Gut. 1970 Aug;11(8):646–648. doi: 10.1136/gut.11.8.646. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Pearse A. G., Coulling I., Weavers B., Friesen S. The endocrine polypeptide cells of the human stomach, duodenum, and jejunum. Gut. 1970 Aug;11(8):649–658. doi: 10.1136/gut.11.8.649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Pearse A. G., Polak J. M. Cytochemical evidence for the neural crest origin of mammalian ultimobranchial C cells. Histochemie. 1971;27(2):96–102. doi: 10.1007/BF00284951. [DOI] [PubMed] [Google Scholar]
  21. Polak J. M., Bussolati G., Pearse A. G. Cytochemical, immunofluorescence and ultrastructural investigations on the antral G cells in hyperparathyroidism. Virchows Arch B Cell Pathol. 1971;9(3):187–197. doi: 10.1007/BF02894045. [DOI] [PubMed] [Google Scholar]
  22. Schimke R. N., Hartmann W. H., Prout T. E., Rimoin D. L. Syndrome of bilateral pheochromocytoma, medullary thyroid carcinoma and multiple neuromas. A possible regulatory defect in the differentiation of chromaffin tissue. N Engl J Med. 1968 Jul 4;279(1):1–7. doi: 10.1056/NEJM196807042790101. [DOI] [PubMed] [Google Scholar]
  23. Snyder N., 3rd, Scurry M. T., Deiss W. P. Five families with multiple endocrine adenomatosis. Ann Intern Med. 1972 Jan;76(1):53–58. doi: 10.7326/0003-4819-76-1-53. [DOI] [PubMed] [Google Scholar]
  24. Solcia E., Sampietro R. Cytologic observations on the pancreatic islets with reference to some endocrine-like cells of the gastrointestinal mucosa. Z Zellforsch Mikrosk Anat. 1965 Dec 10;68(5):689–698. doi: 10.1007/BF00340094. [DOI] [PubMed] [Google Scholar]
  25. UNDERDAHL L. O., WOOLNER L. B., BLACK B. M. Multiple endocrine adenomas; report of 8 cases in which the parathyroids, pituitary and pancreatic islets were involved. J Clin Endocrinol Metab. 1953 Jan;13(1):20–47. doi: 10.1210/jcem-13-1-20. [DOI] [PubMed] [Google Scholar]
  26. Unger R. H., Eisentraut A. M. Entero-insular axis. Arch Intern Med. 1969 Mar;123(3):261–266. [PubMed] [Google Scholar]
  27. Vance J. E., Stoll R. W., Kitabchi A. E., Buchanan K. D., Hollander D., Williams R. H. Familial nesidioblastosis as the predominant manifestation of multiple endocrine adenomatosis. Am J Med. 1972 Feb;52(2):211–227. doi: 10.1016/0002-9343(72)90071-x. [DOI] [PubMed] [Google Scholar]
  28. Vance J. E., Stoll R. W., Kitabchi A. E., Williams R. H., Wood F. C., Jr Nesidioblastosis in familial endocrine adenomatosis. JAMA. 1969 Mar 3;207(9):1679–1682. [PubMed] [Google Scholar]
  29. WERMER P. Genetic aspects of adenomatosis of endocrine glands. Am J Med. 1954 Mar;16(3):363–371. doi: 10.1016/0002-9343(54)90353-8. [DOI] [PubMed] [Google Scholar]
  30. Way L., Goldman L., Dunphy J. E. Zollinger-Ellison syndrome. An analysis of twenty-five cases. Am J Surg. 1968 Aug;116(2):293–304. doi: 10.1016/0002-9610(68)90507-2. [DOI] [PubMed] [Google Scholar]
  31. Weichert R. F., 3rd The neural ectodermal origin of the peptide-secreting endocrine glands. A unifying concept for the etiology of multiple endocrine adenomatosis and the inappropriate secretion of peptide hormones by nonendocrine tumors. Am J Med. 1970 Aug;49(2):232–241. doi: 10.1016/s0002-9343(70)80079-1. [DOI] [PubMed] [Google Scholar]
  32. ZOLLINGER R. M., ELLISON E. H. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg. 1955 Oct;142(4):709-23; discussion, 724-8. [PMC free article] [PubMed] [Google Scholar]

Articles from Annals of Surgery are provided here courtesy of Lippincott, Williams, and Wilkins

RESOURCES