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. 1970 Nov;10(11):1057–1075. doi: 10.1016/S0006-3495(70)86352-4

Simulation of Electrical Interaction of Cardiac Cells

Dennis B Heppner, Robert Plonsey
PMCID: PMC1367982  PMID: 5471697

Abstract

A model of the electrical activity of excitable membrane was used to simulate action potential propagation in cardiac cells. Using an implicit method for solving finite difference equations, propagation through the intercalated disc region between two abutting cells was studied. A model of interaction was constructed and parameters of the cellular junction determined. Estimates of the intercalated disc resistance were then made from these junction parameters using a field analysis of the junction. Values of approximately 4 Ω-cm2 were found and correlate well with experimentally measured values.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barr L., Berger W., Dewey M. M. Electrical transmission at the nexus between smooth muscle cells. J Gen Physiol. 1968 Mar;51(3):347–368. doi: 10.1085/jgp.51.3.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. HODGKIN A. L., HUXLEY A. F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol. 1952 Aug;117(4):500–544. doi: 10.1113/jphysiol.1952.sp004764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Noble D. Applications of Hodgkin-Huxley equations to excitable tissues. Physiol Rev. 1966 Jan;46(1):1–50. doi: 10.1152/physrev.1966.46.1.1. [DOI] [PubMed] [Google Scholar]
  4. Weidmann S. The diffusion of radiopotassium across intercalated disks of mammalian cardiac muscle. J Physiol. 1966 Nov;187(2):323–342. doi: 10.1113/jphysiol.1966.sp008092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Woodbury J. W., Crill W. E. The potential in the gap between two abutting cardiac muscle cells. A closed solution. Biophys J. 1970 Nov;10(11):1076–1083. doi: 10.1016/S0006-3495(70)86353-6. [DOI] [PMC free article] [PubMed] [Google Scholar]

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